Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells

Melanoma cell therapy: Endothelial progenitor cells as shuttle of the MMP12 uPAR-degrading enzyme

(2015) Anna Laurenzana et al.   Oncotarget

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style

(2015) Francesca Margheri et al.   Oncotarget

PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells

(2014) Natalie C. Schlegel et al.   EXPERIMENTAL DERMATOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells

(2013) Silvia Peppicelli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Targeting TGF-β signaling in cancer

(2013) Lior H Katz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β

(2013) Valentina Mele et al.   INTERNATIONAL JOURNAL OF CANCER

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 against LNCaP and PC3 Human Prostate Cancer Cells

(2013) Anna Laurenzana et al.   PLoS One

Human Bone Marrow-Derived Mesenchymal Stem Cells produced TGFbeta Contributes to Progression and Metastasis of Prostate Cancer

(2012) Huamao Ye et al.   CANCER INVESTIGATION

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

GDF5 Regulates TGFß-Dependent Angiogenesis in Breast Carcinoma MCF-7 Cells: In Vitro and In Vivo Control by Anti-TGFß Peptides

(2012) Francesca Margheri et al.   PLoS One

Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae

(2011) F. Margheri et al.   BLOOD

Development of Novel Therapeutics Targeting the Urokinase Plasminogen Activator Receptor (uPAR) and Their Translation Toward the Clinic

(2011) Andrew P. Mazar et al.   CURRENT PHARMACEUTICAL DESIGN

Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)

(2010) F. T. Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Human Bone Marrow-Derived MSCs Can Home to Orthotopic Breast Cancer Tumors and Promote Bone Metastasis

(2010) R. H. Goldstein et al.   CANCER RESEARCH

Transforming growth factor-β and the hallmarks of cancer

(2010) Maozhen Tian et al.   CELLULAR SIGNALLING

Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1

(2010) Manfred Schmitt et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mesenchymal stem cells enhance growth and metastasis of colon cancer

(2010) Kei Shinagawa et al.   INTERNATIONAL JOURNAL OF CANCER

Therapeutic Potential of Adult Bone Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis

(2009) D. Chanda et al.   CLINICAL CANCER RESEARCH

Reversibility of Epithelial-Mesenchymal Transition (EMT) Induced in Breast Cancer Cells by Activation of Urokinase Receptor-dependent Cell Signaling

(2009) Minji Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ1 antagonistic peptides inhibit TGFβ1-dependent angiogenesis

(2008) Simona Serratì et al.   BIOCHEMICAL PHARMACOLOGY

Evolving role of uPA/uPAR system in human cancers

(2008) Kathleen Dass et al.   CANCER TREATMENT REVIEWS

TGFβ in Cancer

(2008) Joan Massagué   CELL