Article
Immunology
Shuai Teng, Zhaowei Zhu, Chenkai Wu, Yuhu He, Shenghua Zhou
Summary: This study discovers that Inflachromene (ICM) can inhibit the phenotypic conversion of vascular smooth muscle cells (VSMCs) and reduce excessive neointimal hyperplasia. ICM regulates the Toll-like receptor 4 (TLR4)-nuclear factor-κB (NF-κB) pathway by inhibiting the expression of high mobility group box proteins (HMGBs) 1 and 2, thereby attenuating neointimal hyperplasia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yuanmin Li, Lingyun Tao, Yawei Xu, Rong Guo
Summary: The study aimed to investigate the impact of the natural antioxidant polyphenol TXL on the phenotype of vascular smooth muscle cells (VSMCs) in abdominal aortic aneurysm (AAA). The results showed that TXL alleviated VSMC injury by promoting cell proliferation, reducing apoptosis, suppressing inflammation, and preventing extracellular matrix (ECM) degradation. Mechanistically, TXL achieved its effects through activating the TLR4/noncanonical NF-κB pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Alicia Carrillo-Sepulveda, Nicole Maddie, Christina Mary Johnson, Cameron Burke, Osina Lutz, Bamwa Yakoub, Benjamin Kramer, Dhandevi Persand
Summary: The study demonstrated that vascular hyperacetylation is associated with vascular smooth muscle cell dysfunction in advanced type 2 diabetes mellitus. Inhibition of hyperacetylation by garcinol reduced high glucose-induced ROS production in VSMCs, highlighting a potential novel therapeutic approach for diabetic vascular complications.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Wenjuan Yang, Andreas Denger, Caroline Diener, Frederic Kueppers, Leticia Soriano-Baguet, Gertrud Schaefer, Archana K. Yanamandra, Renping Zhao, Arne Knoerck, Eva C. Schwarz, Martin Hart, Frank Lammert, Leticia Prates Roma, Dirk Brenner, Grigorios Christidis, Volkhard Helms, Eckart Meese, Markus Hoth, Bin Qu
Summary: TRAIL expression is increased in cytotoxic T lymphocytes (CTLs) in high glucose environments, potentially contributing to the progression of diabetes. Non-mitochondrial reactive oxygen species, NF kappa B, and PI3K/Akt play crucial roles in the upregulation of TRAIL in CTLs induced by high glucose. TRAIL(high) CTLs induce apoptosis of pancreatic beta cells. Treatment with metformin and vitamin D can reduce the enhanced expression of TRAIL in CTLs caused by high glucose and protect pancreatic beta cells from TRAIL-mediated apoptosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Haohang Ruan, Qing Huang, Benting Wan, Ming Yang
Summary: Curcumin can alleviate inflammatory damage in vascular smooth muscle cells induced by LPS by inhibiting the release of inflammatory cytokines, increasing cell viability, and reducing apoptosis. Additionally, curcumin increases the expression of TLR4 and acts through blocking NF-κB and JNK signaling pathways.
INFLAMMOPHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Jaime Ibarrola, Qing Lu, Maria-Christina Zennaro, Iris Z. Jaffe
Summary: This study investigated the regulatory mechanisms of MR gene transcription in aging human smooth muscle cells. The results revealed the involvement of the inflammatory transcription factor NF kappa B and the hypoxia-inducible factor HIF1 alpha in the regulation of SMC MR transcription, which contributes to aging-related vascular stiffness and cardiovascular disease.
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Hyun Hwangbo, EunJin Bang, Su Hyun Hong, Kyoung Seob Song, Jeong Sook Noh, Do-Hyung Kim, Gi-Young Kim, Yung Hyun Choi
Summary: Diabetic retinopathy (DR) is a leading cause of vision loss and is commonly seen in diabetic patients. In this study, the researchers investigated the protective effects of beta-asarone, a compound extracted from Acori graminei Rhizoma, on human retinal pigment epithelial (RPE) ARPE-19 cells under high-glucose conditions. They found that beta-asarone significantly reduced oxidative damage in the cells by scavenging reactive oxygen species (ROS) and inhibiting the activation of the NF-kappa B/NLRP3 inflammasome pathway. These findings suggest that beta-asarone may have potential therapeutic applications in the treatment of diabetic retinopathy.
Article
Chemistry, Analytical
Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan, Xiao-Feng Yang
Summary: Hydrogen sulfide (H2S) is a vital endogenous signal molecule with critical physiological functions, but its site-specific delivery and release in biological systems remains a challenge. The newly developed Pro-S donor shows excellent release efficiency and live-cell compatibility, allowing real-time capturing of H2S and demonstrating anti-inflammatory effects in cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Yexiao Yan, Xiangxing Chen, Junpeng Huang, Changchao Huan, Chengmin Li
Summary: This study investigated the effects and mechanisms of H2O2-induced oxidative stress on meat quality of broiler thigh muscle. The results showed that oxidative stress significantly impaired the meat quality by affecting apoptosis, abnormal autophagy, and the ROS/NF-kappa B signaling pathway activation.
Article
Endocrinology & Metabolism
Wei-Jian Fan, Ling-Di Lao, Feng Xiao, Yu-Xiang Weng, Jian-Wei Pan
Summary: This study found that lncRNA NR2F1-AS1 is upregulated in IA patients while AGTR1 is downregulated. The overexpression of NR2F1-AS1 inhibits VSMC proliferation and promotes apoptosis by downregulating AGTR1 and the NF-kB signaling pathway, thus promoting the development of IA.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Fei Liao, Ling Wang, Zhinan Wu, Guqing Luo, Yuxuan Qian, Xinjie He, Song Ding, Jun Pu
Summary: This study identified the protective effect of disulfiram against angiotensin II-induced vascular smooth muscle cells (VSMCs) pyroptosis in abdominal aortic aneurysm (AAA). Disulfiram reduced inflammation, pyroptosis, and oxidative stress, and ameliorated AAA formation in vivo.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nanxin Ma, Jian Guo, Xiaolong Wu, Zhenzhong Liu, Tian Yao, Qian Zhao, Ben Li, Fengjie Tian, Xiaoyan Yan, Wenping Zhang, Yulan Qiu, Yi Gao
Summary: This article systematically reviews and analyzes the changes in TLR4 signaling pathway-related proteins induced by arsenic exposure through meta-analysis, providing important theoretical basis for understanding the toxicity of arsenic and the mechanism of immune system damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yadong Li, Haide Li, Bin Chen, Fan Yang, Zhiying Hao
Summary: The study identified that miR-141-5p is downregulated in the plasma and VSMCs of AS patients and animal models. It functions as a protective factor during the development of AS by targeting the HMGB1/NF-kappa B pathway to inhibit VSMCs dysfunction.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Alexandre Moura-Assis, Pedro A. S. Nogueira, Jose C. de-Lima-Junior, Fernando M. Simabuco, Joana M. Gaspar, Jose Donato Jr, Licio A. Velloso
Summary: The knockdown of TLR4-interactor with leucine-rich repeats (Tril) reduces hypothalamic inflammation, increases whole-body energy expenditure, and improves systemic glucose tolerance to protect against diet-induced obesity. Knockdown of Tril in POMC neurons results in decreased body fat, reduced white adipose tissue inflammation, and a trend towards increased leptin signaling. Tril is identified as a new component in the mechanisms promoting hypothalamic dysfunction in experimental obesity, presenting a novel target for obesity treatment.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Takayuki Matsumoto, Keisuke Takayanagi, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2020)
Review
Peripheral Vascular Disease
Takayuki Matsumoto, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Article
Cardiac & Cardiovascular Systems
Jessica M. Ponce, Grace Coen, Kathryn M. Spitler, Nikola Dragisic, Ines Martins, Antentor Hinton, Margaret Mungai, Satya Murthy Tadinada, Hao Zhang, Gavin Y. Oudit, Long-Sheng Song, Na Li, Peter Sicinski, Stefan Strack, E. Dale Abel, Colleen Mitchell, Duane D. Hall, Chad E. Grueter
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Takayuki Matsumoto, Mihoka Kojima, Keisuke Takayanagi, Tomoki Katome, Kumiko Taguchi, Tsuneo Kobayashi
PURINERGIC SIGNALLING
(2020)
Article
Multidisciplinary Sciences
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Elevated plasma triglyceride levels are associated with metabolic disease, and angiopoietin-like protein 4 (ANGPTL4) plays a role in regulating these levels. Adipocyte-specific deficiency of ANGPTL4 in mice led to changes in triglyceride metabolism, including higher adipose LPL activity and increased triglyceride uptake. However, the beneficial effects on glucose homeostasis seen initially were lost after chronic high-fat feeding.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study demonstrated that methylglyoxal may enhance uridine diphosphate-induced contraction in rat carotid arteries, potentially through the activation of p38 MAPK and protein kinase C, and increased oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Physiology
Takayuki Matsumoto, Keisuke Takayanagi, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
Summary: The study demonstrates that indoxyl sulfate enhances ET-1-induced contraction in rat aortas through impairment of NO/cGMP signaling and antioxidant systems.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Kumiko Taguchi, Nozomu Kaneko, Kanami Okudaira, Takayuki Matsumoto, Tsuneo Kobayashi
Summary: The study investigated the effects of the ERK1/2 inhibitor PD98059 on aortas and DM MPs, finding that PD98059 improved endothelial dysfunction in DM and partly blocked the adhesion properties of DM MPs via ERK and ICAM-1. These effects may explain some of the vascular complications in diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Madoka Yoshioka, Aiko Yamada, Kumiko Taguchi, Tsuneo Kobayashi
Summary: Methylglyoxal (MGO) enhances UDP-induced contraction in rat femoral arteries, possibly due to alterations in the activities of Syk tyrosine kinase and p38 MAPK in the smooth muscle.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Miyo Kudo, Tomoe Osada, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study found that methylglyoxal (MGO) impairs relaxation induced by ATP and UTP in rat carotid arteries, mainly through suppressing P2Y(2) receptor-mediated signaling and reducing endothelial NO. Additionally, MGO contributes to vasoconstriction through increased oxidative stress and COX-derived prostanoids.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Physiology
Takayuki Matsumoto, Natsume Taguchi, Keisuke Ozawa, Kumiko Taguchi, Tsuneo Kobayashi
Summary: In this study, we found that indoxyl sulfate inhibits Up(4)A-mediated contraction in renal arteries, possibly by activating ectonucleotidase rather than AhR. This discovery has important implications for the pathophysiology of purinergic signaling.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Physiology
Kumiko Taguchi, Kanami Okudaira, Takayuki Matsumoto, Tsuneo Kobayashi
Summary: Ginkgo biloba extract (GBE) lowers cardiovascular disease risk by protecting against endothelial dysfunction caused by diabetes. This protection is achieved through the activation of SOD1 and the Akt/eNOS signaling pathway.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Kumiko Taguchi, Tsuneo Kobayashi
Summary: Regulating vascular tone is crucial for maintaining vascular health, and TRPV4 plays an important role in the functions of ECs and VSMCs. It is involved in regulating vascular constriction and relaxation by modulating intracellular calcium levels, and has implications in pathophysiological states such as hypertension, diabetes, and obesity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Keisuke Takayanagi, Tomoki Katome, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
Summary: Enhanced contractile responses to UDP and UTP were observed in femoral arteries of SHR compared to WKY in both 12-month-old and 7-month-old rats under hypertension, while endothelium-denuded arteries showed increased contractions induced by UDP and UTP. Inhibition of cyclooxygenase decreased contractions induced by these nucleotides and eliminated differences in responses between SHR and WKY groups. This study highlights the importance of regulating extracellular uridine nucleotides-induced contractions in hypertension-associated peripheral arterial diseases.