60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C

Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity

(2016) Dhivya Kumar et al.   JOURNAL OF CELL SCIENCE

Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme

(2015) Mathilde L. Bonnemaison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

(2015) Peter D. Simpson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide-gated ion channels and the simple nervous system of Hydra

(2015) S. Grunder et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Reduction in C-terminal amidated species of recombinant monoclonal antibodies by genetic modification of CHO cells

(2014) Mihaela Škulj et al.   BMC BIOTECHNOLOGY

Novel Cell Types, Neurosecretory Cells, and Body Plan of the Early-Diverging Metazoan Trichoplax adhaerens

(2014) Carolyn L. Smith et al.   CURRENT BIOLOGY

A Histidine-rich Linker Region in Peptidylglycine α-Amidating Monooxygenase Has the Properties of a pH Sensor

(2014) Kurutihalli Vishwanatha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

AP-1A Controls Secretory Granule Biogenesis and Trafficking of Membrane Secretory Granule Proteins

(2014) Mathilde Bonnemaison et al.   TRAFFIC

Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum

(2014) Eric D Gaier et al.   BMC Endocrine Disorders

HHM Motif at the CuH-Site of Peptidylglycine Monooxygenase is a pH-Dependent Conformational Switch

(2013) Chelsey D. Kline et al.   BIOCHEMISTRY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global view of the evolution and diversity of metazoan neuropeptide signaling

(2013) G. Jekely   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling from the secretory granule to the nucleus

(2012) Chitra Rajagopal et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lumenal Loop M672-P707 of the Menkes Protein (ATP7A) Transfers Copper to Peptidylglycine Monooxygenase

(2012) Adenike Otoikhian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A "Neural" Enzyme in Nonbilaterian Animals and Algae: Preneural Origins for Peptidylglycine  -Amidating Monooxygenase

(2012) R. M. F. Attenborough et al.   MOLECULAR BIOLOGY AND EVOLUTION

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

(2012) Jeroen R Huyghe et al.   NATURE GENETICS

A Novel Role of RASSF9 in Maintaining Epidermal Homeostasis

(2011) Chiou-Mei Lee et al.   PLoS One

Probing the Peptidylglycine α-Hydroxylating Monooxygenase Active Site with Novel 4-Phenyl-3-butenoic Acid Based Inhibitors

(2010) Emma Langella et al.   ChemMedChem

Secretion Stimulates Intramembrane Proteolysis of a Secretory Granule Membrane Enzyme

(2010) Chitra Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Substrate Preorganization in the Peptidylglycine α-Amidating Monooxygenase Reaction Describing the Contribution of Ground State Structure to Hydrogen Tunneling

(2010) Neil R. McIntyre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Signaling from the Secretory Granule to the Nucleus: Uhmk1 and PAM

(2010) Victor P. Francone et al.   MOLECULAR ENDOCRINOLOGY

The BBSome

(2009) Hua Jin et al.   CURRENT BIOLOGY

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Secretory Granule to the Nucleus

(2009) Chitra Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins

(2009) J. A. Sobota et al.   JOURNAL OF CELL SCIENCE

Can faulty antennae increase adiposity? The link between cilia proteins and obesity

(2009) Piya Sen Gupta et al.   JOURNAL OF ENDOCRINOLOGY

Proteomic Analysis of Human Parotid Gland Exosomes by Multidimensional Protein Identification Technology (MudPIT)

(2009) Mireya Gonzalez-Begne et al.   JOURNAL OF PROTEOME RESEARCH

Interactions of peptide amidation and copper: Novel biomarkers and mechanisms of neural dysfunction

(2009) Danielle Bousquet-Moore et al.   NEUROBIOLOGY OF DISEASE

Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme

(2009) Eduardo E. Chufán et al.   STRUCTURE

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM)

(2008) David J. Merkler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reversal of Physiological Deficits Caused by Diminished Levels of Peptidylglycine α-Amidating Monooxygenase by Dietary Copper

(2008) D. Bousquet-Moore et al.   ENDOCRINOLOGY

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

(2008) Kamal Rahmouni et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of novel candidate protein biomarkers for the post-polio syndrome — Implications for diagnosis, neurodegeneration and neuroinflammation

(2008) Henrik Gonzalez et al.   Journal of Proteomics

Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors

(2008) Nicolas F. Berbari et al.   MOLECULAR BIOLOGY OF THE CELL

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

(2008) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

nemy encodes a cytochrome b561 that is required for Drosophila learning and memory

(2008) K. G. Iliadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA