Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Food Science & Technology
Heui Min Lim, See-Hyoung Park
Summary: Cancer and diabetes mellitus are life-threatening diseases that share common risk factors. Conventional treatments for these diseases have limitations such as side effects, economic burdens, and patient compliance. Phytochemicals from edible plants, with their antioxidant and pro-oxidant properties, have emerged as alternative therapeutic options. These naturally occurring compounds have beneficial effects and can regulate cell proliferation, differentiation, cell cycle arrest, and apoptosis, offering preventive and therapeutic effects against cancer and diabetes. This article summarizes recent studies on the antioxidant or pro-oxidant effects and underlying mechanisms of flavonoids, alkaloids, and saponins in cancer or diabetic models.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cell Biology
Yuki Maeda, Akihiro Isomura, Taimu Masaki, Ryoichiro Kageyama
Summary: Oscillatory Hes1 expression activates cell proliferation by down-regulating the expression of p21, while sustained Hes1 overexpression inhibits cell proliferation by up-regulating p21 expression indirectly. This suggests that Hes1 differentially controls neural stem cell proliferation depending on its expression dynamics.
Review
Immunology
Hao-Yun Peng, Jason Lucavs, Darby Ballard, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Jianxun Song
Summary: T cells undergo metabolic reprogramming and various biological processes throughout their lifespan, with the imbalance of ROS generation potentially resulting in severe cellular damage and death. Despite playing an essential role in T cell immunity, ROS can also lead to T cell-related diseases. Recent research has highlighted the effects of ROS on T cell activities within T cell immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Zicheng Xie, Jie Zhang, Yu Xiao, Yangcenzi Xie, Wenkun Zhu, Shuyi Yu, Tingting Hou, Shuquan Liang, Liangbing Wang
Summary: Grain boundaries in metal oxides are found to easily regulate reactive oxygen species (ROS) in aerobic oxidation reactions. MoO3-600 nanocrystals with high density of grain boundaries exhibit excellent catalytic performance and selectivity in the aerobic oxidation process.
ENERGY & ENVIRONMENTAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Guangbi Li, Dandan Huang, Ningjun Li, Joseph K. Ritter, Pin-Lan Li
Summary: The study found that ROS levels increased in podocytes after Hcy stimulation, leading to activation of NLRP3 inflammasomes and the presence of inflammatory cytokines in MVBs. Inhibiting NADPH oxidase and using ROS scavengers prevented these effects.
Article
Biochemistry & Molecular Biology
Nerilson M. Lima, Gagan Preet, Sara R. Marqui, Thais de O. R. S. Falcoski, Geovana Navegante, Christiane P. Soares, Teresinha de Jesus A. S. Andrade, Felipe A. La Porta, Harinantenaina Liva R. Rakotondraie, Marcel Jaspars, Dulce H. S. Silva
Summary: This study evaluated the metabolic profiling and antigenotoxicity of Inga species with potential antitumor effects. It also used a proteomic approach to investigate the response of HepG2 cells to polyphenols isolated from I. laurina. The results showed cytotoxic activity against cancer cell lines and identified potential bioactive compounds. The proteomic analysis revealed proteins related to ROS elimination, DNA repair, tumor protein expression, and apoptosis.
Review
Cell Biology
Hamid Aria, Farhoodeh Ghaedrahmati, Mazdak Ganjalikhani-Hakemi
Summary: The term immunometabolism refers to intracellular metabolic changes within immune cells, influencing immune responses and being a key feature in immune cell activation and cancer cell progression. Due to its significance in immunotherapy, studying the immunometabolic situation of cells and understanding cancer cell metabolism can lead to innovative cancer treatment strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Niklas Mueller, Timothy Warwick, Kurt Noack, Pedro Felipe Malacarne, Arthur J. L. Cooper, Norbert Weissmann, Katrin Schroeder, Ralf P. Brandes, Flavia Rezende
Summary: ROS play a crucial role in cardiovascular signal transduction, with different types and concentrations leading to distinct metabolic and transcriptomic responses in endothelial cells. High levels of H2O2 significantly impact both metabolism and gene expression, while other ROS mainly affect gene expression levels.
Review
Biochemistry & Molecular Biology
Ali A. A. Akhiani, Anna Martner
Summary: Activation of NADPH oxidases (NOX) and the resulting formation of reactive oxygen species (ROS) play important roles in antimicrobial defense and oncogenesis. Enhanced NOX activity has been linked to the activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in various malignancies. This review examines the role of PI3K in regulating NOX-induced ROS formation in cancer.
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jan Dudek, Ilona Kutschka, Christoph Maack
Summary: Cardiovascular stem cells are crucial for tissue regeneration and repair, with their differentiation process being influenced by metabolism and cellular redox state. Reactive oxygen species play a significant role in stem cell differentiation and tissue renewal, but can also contribute to cellular aging.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Chemistry, Multidisciplinary
Jiang-Pei Yuan, Zong-Jie Guan, Heng-Yu Lin, Bing Yan, Kang-Kai Liu, Hong-Cai Zhou, Yu Fang
Summary: Mimicking the active site and substrate binding cavity of enzymes, PCCs can achieve specificity in catalytic reactions. PCC-6-M (M = Zn/Ni/Co) exhibit distinct catalytic activities, which are significant for studying the regulation of ROS generation by supramolecular catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Food Science & Technology
Xin Kang, Zihan Gao, Lingjie Zheng, Xiaoru Zhang, Hao Li
Summary: Co-cultivation of Lactobacillus plantarum with Saccharomyces cerevisiae can reduce intracellular reactive oxygen species levels in yeast cells, increase oxidative tolerance, and promote ATP production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Weiqing Zhang, Robert D. Willows, Rui Deng, Zheng Li, Mengqi Li, Yan Wang, Yunling Guo, Weida Shi, Qiuling Fan, Shelley S. Martin, Nathan C. Rockwell, J. Clark Lagarias, Deqiang Duanmu
Summary: The biosynthesis of chlorophyll and heme in oxygenic phototrophs follows a common pathway that diverges with the insertion of magnesium or iron. The interaction of bilins with GENOMES UNCOUPLED 4 (GUN4) stimulates the enzymatic activity of magnesium chelatase (MgCh) and stabilizes the accumulation of protoporphyrin IX-binding CrCHLH1 subunit of MgCh. GUN4: bilin complexes play dual regulatory roles in sustaining bilin biosynthesis and chlorophyll biosynthesis in illuminated oxic environments of all photosynthetic eukaryotes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Irene de Cesare, Criseida G. Zamora-Chimal, Lorena Postiglione, Mahmoud Khazim, Elisa Pedone, Barbara Shannon, Gianfranco Fiore, Giansimone Perrino, Sara Napolitano, Diego di Bernardo, Nigel J. Savery, Claire Grierson, Mario di Bernardo, Lucia Marucci
Summary: This paper introduces ChipSeg, a computational tool for segmenting and tracking cells in microfluidic devices, which can be applied in external feedback control experiments, with efficient and robust segmentation capabilities.
Review
Biochemistry & Molecular Biology
Daniela Intartaglia, Giuliana Giamundo, Ivan Conte
Summary: The retinal pigment epithelium (RPE) plays a crucial role in maintaining the function of photoreceptors and responding to stress conditions. Autophagy is a cellular self-regulation process that helps in digestion and recycling of cell components to meet cellular demands.
Article
Multidisciplinary Sciences
Giansimone Perrino, Sara Napolitano, Francesca Galdi, Antonella La Regina, Davide Fiore, Teresa Giuliano, Mario di Bernardo, Diego di Bernardo
Summary: The authors have successfully achieved long-term synchronization of a population of genetically modified yeast cells using a cyber-genetic system, providing a new avenue for cell cycle synchronization.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Sabrina Carrella, Filomena Massa, Alessia Indrieri
Summary: The retina is a highly metabolically active tissue with unique mitochondrial distribution vital for energy supply. Mitochondrial dysfunction has been correlated with visual loss and neuro-ophthalmic manifestations in various retinal diseases. miRNAs are considered key regulators in retinal degeneration and potential biomarkers for disease prediction and prognosis, making them crucial targets for clinical applications in eye diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Nunziana Pezzella, Guglielmo Bove, Roberta Tammaro, Brunella Franco
Summary: The OFD1 protein is crucial for the formation of primary cilia and left-right asymmetry establishment and has additional functions. Mutations in OFD1 lead to various phenotypes with different inheritance patterns. The extensive clinical manifestations observed in OFD1-mutated patients highlight the complexity of genetic diseases.
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2022)
Article
Medicine, Research & Experimental
Antonietta Tarallo, Carla Damiano, Sandra Strollo, Nadia Minopoli, Alessia Indrieri, Elena Polishchuk, Francesca Zappa, Edoardo Nusco, Simona Fecarotta, Caterina Porto, Marcella Coletta, Roberta Iacono, Marco Moracci, Roman Polishchuk, Diego Luis Medina, Paola Imbimbo, Daria Maria Monti, Maria Antonietta De Matteis, Giancarlo Parenti
Summary: Oxidative stress affects the efficacy of enzyme replacement therapy in Pompe disease, and correction of oxidative stress may improve treatment outcomes. Antioxidant co-administration with rhGAA enhances enzyme activity and processing, suggesting a potential strategy to improve therapies for Pompe disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Giovanni Annona, Jose Luis Ferran, Pasquale De Luca, Ivan Conte, John H. Postlethwait, Salvatore D'Aniello
Summary: Fish play a crucial role in understanding vertebrate adaptation and gene family evolution, with the gaseous messenger nitric oxide (NO) being involved in various biological processes. By investigating the expression patterns of nitric oxide synthases (Nos) and the nos1 gene in different fish species, researchers have revealed both the conserved expression domains and species-specific territories of nos1, expanding our knowledge on the evolution and functions of the NO system in aquatic organisms.
Article
Medicine, Research & Experimental
Sabrina Carrella, Martina Di Guida, Simona Brillante, Davide Piccolo, Ludovica Ciampi, Irene Guadagnino, Jorge Garcia Piqueras, Mariateresa Pizzo, Elena Marrocco, Marta Molinari, Georgios Petrogiannakis, Sara Barbato, Yulia Ezhova, Alberto Auricchio, Brunella Franco, Elvira De Leonibus, Enrico Maria Surace, Alessia Indrieri, Sandro Banfi
Summary: The downregulation of miR-181a/b has beneficial effects on retinal diseases by promoting mitochondrial turnover and improving retinal morphology and function. This suggests that miR-181a/b downregulation could serve as an innovative mutation-independent therapeutic strategy for inherited retinal diseases.
EMBO MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Manuela Morleo, Nunziana Pezzella, Brunella Franco
Summary: The balance of protein synthesis and degradation is crucial for cellular homeostasis and biological processes. Recent studies have revealed that centrosomal/ciliary proteins play a role in proteome control in response to spatial or microenvironmental stimuli. Understanding this balance in ciliopathies may lead to the identification of novel therapeutic targets for these genetic disorders.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Pietro Carotenuto, Alessia Romano, Anna Barbato, Paola Quadrano, Simona Brillante, Mariagrazia Volpe, Luigi Ferrante, Roberta Tammaro, Manuela Morleo, Rossella De Cegli, Antonella Iuliano, Marialuisa Testa, Fabrizio Andreone, Gennaro Ciliberto, Eduardo Clery, Giancarlo Troncone, Giuseppe Palma, Claudio Arra, Antonio Barbieri, Mariaelena Capone, Gabriele Madonna, Paolo A. Ascierto, Luisa Lanfrancone, Alessia Indrieri, Brunella Franco
Summary: This study identifies the MITF/APAF-1 axis as a molecular driver of MAPK inhibitor resistance in melanoma, and quinacrine and methylbenzethonium as potent activators of apoptosis and suppressors of MITF function, demonstrating their potential as therapeutic approaches for resistant melanoma.
Article
Cell Biology
Maria Rosito, Caterina Sanchini, Giorgio Gosti, Manuela Moreno, Simone De Panfilis, Maria Giubettini, Doriana Debellis, Federico Catalano, Giovanna Peruzzi, Roberto Marotta, Alessia Indrieri, Elvira De Leonibus, Maria Egle De Stefano, Davide Ragozzino, Giancarlo Ruocco, Silvia Di Angelantonio, Francesca Bartolini
Summary: Activated microglia undergo a remodeling of the microtubule cytoskeleton, transitioning from a non-centrosomal array of parallel and stable microtubules to a radial array of more dynamic microtubules. Microtubule nucleation occurs at Golgi outposts in the homeostatic state, while activation signaling recruits nucleating material nearby the centrosome, a process inhibited by microtubule stabilization.
Article
Cell Biology
Kishor Pant, Seth Richard, Estanislao Peixoto, Jun Yin, Davis M. Seelig, Pietro Carotenuto, Massimiliano Salati, Brunella Franco, Lewis R. Roberts, Sergio A. Gradilone
Summary: The study reveals that targeting the NAMPT/NAD+ pathway with FK866 can inhibit the growth of CCA cells and alter their mitochondrial metabolism. Additionally, FK866 enhances the anticancer effects of cisplatin in vitro. These findings suggest that NAMPT/NAD+ pathway may be a potential therapeutic target for CCA, and FK866 may serve as a useful medication in combination with cisplatin.
Article
Cell Biology
Federico Catalano, Thomas J. O'Brien, Aleksandra A. Mekhova, Lucia Vittoria Sepe, Mariantonietta Elia, Rossella De Cegli, Ivan Gallotta, Pamela Santonicola, Giuseppina Zampi, Ekaterina Y. Ilyechova, Aleksei A. Romanov, Polina D. Samuseva, Josephine Salzano, Raffaella Petruzzelli, Elena V. Polishchuk, Alessia Indrieri, Byung-Eun Kim, Andre E. X. Brown, Ludmila V. Puchkova, Elia Di Schiavi, Roman S. Polishchuk
Summary: This study generated a mutant Caenorhabditis elegans strain to study copper toxicity in Wilson disease. The mutant animals exhibited poor resistance to copper and displayed developmental delay, shortened lifespan, impaired motility, oxidative stress pathway activation, and mitochondrial damage. The findings suggest that the mutant strain could be a valuable model for studying copper toxicity in Wilson disease.
Review
Genetics & Heredity
Mina Kolahdouzmohammadi, Roya Kolahdouz-Mohammadi, Seyed Abdolhossein Tabatabaei, Brunella Franco, Mehdi Totonchi
Summary: Autophagy is a highly conserved biological process that controls intracellular recycling and is crucial for cellular homeostasis and differentiation programs, including cardiomyocyte differentiation. The interaction between autophagy and signaling pathways such as FGF, Wnt, Notch, and BMPs is essential for controlling cardiac differentiation. Modulating autophagy has been shown to improve cardiac differentiation and generate mature cardiac cells, highlighting the importance of further studying autophagy in this process.
Review
Genetics & Heredity
Pietro Carotenuto, Sergio A. Gradilone, Brunella Franco
Summary: Cilia are microtubule-based organelles that project from the cell surface with motility or sensory functions. The primary cilia work as antennae to sense and transduce extracellular signals. Recent studies have shown that primary cilia play important roles in autophagy and genome stability, which are crucial in oncogenesis.