期刊
ANIMAL GENETICS
卷 46, 期 4, 页码 457-461出版社
WILEY
DOI: 10.1111/age.12309
关键词
antisense RNA; horn growth; polledness; relaxin; insulin-like family peptide receptor 2; sheep
资金
- Swiss National Science Foundation [31003A_141228]
- Swiss National Science Foundation (SNF) [31003A_141228] Funding Source: Swiss National Science Foundation (SNF)
Sheep breeds show a broad spectrum of different horn phenotypes. In most modern production breeds, sheep are polled (absence of horns), whereas horns occur mainly in indigenous breeds. Previous studies mapped the responsible locus to the region of the RXFP2 gene on ovine chromosome10. A 4-kb region of the 3-end of RXFP2 was amplified in horned and polled animals from seven Swiss sheep breeds. Sequence analysis identified a 1833-bp genomic insertion located in the 3-UTR region of RXFP2 present in polled animals only. An efficient PCR-based genotyping method to determine the polled genotype of individual sheep is presented. Comparative sequence analyses revealed evidence that thepolled-associated insertion adds a potential antisense RNA sequence of EEF1A1 to the 3-end of RXFP2 transcripts.
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