期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 89, 期 -, 页码 59-67出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2015.02.002
关键词
MicroRNAs; Cardiomyocyte; Proliferation; Apoptosis; Necrosis; Autophagy
资金
- Excellence Cluster REBIRTH
- German Research Foundation [TH903/11-1]
Cardiovascular diseases are currently the main cause of morbidity and mortality worldwide. Ischemic heart disease, in particular, is responsible for the majority of cardiac-related deaths. Given the negligible regenerative potential of the human myocardium, there is a strong need for therapeutic strategies aiming at enhancing cardiomyocyte survival and proliferation following injury or at inhibiting their death. MicroRNAs (miRNAs) are small non-coding RNA molecules regulating gene expression at a post-transcriptional level with important functions in cardiovascular physiology and disease. It has been demonstrated that miRNAs can influence the ability of cardiomyocytes to enter the cell cycle and/or escape from death pathways. Additionally, long non coding-RNAs could be involved in such pathways. This review summarizes recent evidences on noncoding RNAs regulating proliferation and death of cardiomyocytes representing a future therapeutic for the treatment of heart diseases. This article is part of a Special Issue entitled SI: Non-coding RNAs. (c) 2015 Elsevier Ltd. All rights reserved.
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