期刊
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
卷 37, 期 1, 页码 40-47出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compmedimag.2012.11.001
关键词
Brain; SPECT; Tc-99m HMPAO; Circumferential profile; Vascular dementia; Alzheimer's disease
资金
- UAB Health Services Foundation-General Endowment Fund [200702]
Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients. (c) 2012 Elsevier Ltd. All rights reserved.
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