期刊
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
卷 32, 期 7, 页码 631-637出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compmedimag.2008.07.003
关键词
Locally self-similar processes; Fractal dimension; Long-range dependence; Apoptosis; Morphology
资金
- SAGA [66-02-03-0083]
Chromatin morphologies in human breast cancer cells treated with an anti-cancer agent are analyzed at their early stage of programmed cell death or apoptosis. The gray-level images of nuclear chromatin are modelled as random fields. We used two-dimensional isotropic generalized Cauchy field to characterize local self-similarity and global long-range dependence behaviors in the image spatial data. Generalized Cauchy field allows the description of fractal behavior inferred from fractal dimension and the long-range dependence inferred from correlation exponent to be carried out independently. We demonstrated the usefulness of locally self-similar random fields with long-range dependence for modelling chromatin condensation. (C) 2008 Elsevier Ltd. All rights reserved.
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