Article
Microbiology
J. Chase McNeil, Lauren M. Sommer, Jesus G. Vallejo, Mary Boyle, Kristina G. Hulten, Sheldon L. Kaplan, Stephanie A. Fritz
Summary: In the late 1940s to 1950s, Staphylococcus aureus isolates first gained resistance to penicillin. Recently, some centers have noted an increase in the proportion of methicillin susceptible S. aureus (MSSA) that are also susceptible to penicillin (PSSA).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Adham Mohamed, Nicholas Bennett, Jeannette Ploetz, Laura Aragon, Kevin Kennedy, Sarah Boyd
Summary: This study compared the safety and efficacy of ceftriaxone (CRO) and cefazolin (CZO) in the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The results showed no difference in the clinical cure rate between CRO and CZO at 28 days or at discharge. There were also no differences in treatment failure, safety events, and other secondary endpoints between the two groups. The findings suggest that there is no clinical difference between CRO and CZO for the definitive treatment of MSSA bacteremia.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
A. J. Heffernan, F. B. Sime, S. Mohd Sazlly Lim, S. Adiraju, S. C. Wallis, J. Lipman, G. D. Grant, J. A. Roberts
Summary: This study investigated the pharmacodynamics of ceftriaxone against methicillin-susceptible Staphylococcus aureus (MSSA) and determined the optimal dosage. The results showed that only a high ceftriaxone dose of 2 g twice daily achieved bacterial killing and sustained inhibition of bacterial growth.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Tanis C. Dingle, Dulini Gamage, Sara Gomez-Villegas, Blake M. Hanson, Jinnethe Reyes, April Abbott, Carey-Ann D. Burnham, Jennifer Dien Bard, Stephanie Fritz, William R. Miller, Lars F. Westblade, Barbara Zimmer, Cesar A. Arias, Susan Butler-Wu
Summary: This multicenter study evaluated the prevalence of the cefazolin inoculum effect (CzIE) in North American methicillin-susceptible Staphylococcus aureus (MSSA) isolates. The study found that the CzIE was present in 18.6% of MSSA isolates, with varying prevalence across different study sites. Furthermore, more CzIE-positive isolates had a cefazolin MIC of 1.0 μg/mL, while more CzIE-negative isolates had a MIC of 0.25 μg/mL.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Microbiology
Jeong Eun Lee, Shinwon Lee, Sohee Park, Soon O. Lee, Sun H. Lee
Summary: This study found that dysfunctional accessory gene regulator (agr) is associated with higher mortality in invasive methicillin-resistant Staphylococcus aureus infections. However, the association between agr dysfunction and mortality in methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B) was not significant. The functionality of agr in causative organisms may impact patients' outcomes in MSSA-B with moderate severity.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biology
Low Yi Xin, Toh Hui Min, Puteri Nur Liyana Mohd Zin, Thiruchelvi Pulingam, Jimmy Nelson Appaturi, Thaigarajan Parumasivam
Summary: This study evaluates the antibacterial activities of 61 plant extracts from 49 Malaysian ethnomedicinal plants, with 7 plant extracts showing good efficacy against MSSA strains. When combined with vancomycin and ciprofloxacin, the active plant extracts showed no interaction against MSSA and MRSA strains.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Microbiology
Ryota Miyazawa, So Shimoda, Keiichi Matsuda, Ryuta Tobe, Tasuke Ando, Hiroshi Yoneyama
Summary: Staphylococcus aureus is a major pathogen in humans and livestock, causing serious issues such as bovine mastitis. This study monitored cases of intramammary infection caused by S. aureus in the Miyagi Prefecture, Japan, and analyzed the strains obtained from dairy farms. The study found recurrent cases of infection and identified a Methicillin-Sensitive SA (MSSA) ST398 strain isolated from mastitis-containing cows, which is the first confirmed case in Japan. The results highlight the importance of nationwide surveillance to manage the distribution of ST398 strains in dairy farms for human and animal health.
Article
Pathology
Jill Parkes-smith, Haakon Bergh, Patrick N. A. Harris
Summary: Staphylococcus aureus bacteraemia has high morbidity and mortality, and timely use of effective antibiotics is crucial. Molecular diagnostics can shorten the time from blood culture positivity to identification of MRSA or MSSA.
Review
Infectious Diseases
Zachary A. Yetmar, Samrah Razi, Tarek Nayfeh, Dana J. Gerberi, Maryam Mahmood, Omar M. Abu Saleh
Summary: Current evidence suggests there is no difference in efficacy between ceftriaxone and ASAs for MSSA infection, with a lower risk of toxicity with ceftriaxone.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Anthony D. Bai, Aidan Findlater, Neal Irfan, Nishma Singhal, Mark Loeb
Summary: The study compared the effectiveness of cefazolin and cloxacillin as definitive antibiotic therapy for MSSA SEA. Results showed that cefazolin was likely as effective as an antistaphylococcal penicillin and could be considered as a first-line treatment for MSSA SEA.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Pharmacology & Pharmacy
Wesley D. Kufel, Zoey Zagoria, Bruce E. Blaine, Jeffrey M. Steele, Rahul Mahapatra, Kristopher M. Paolino, Stephen J. Thomas
Summary: This study evaluated the effectiveness and safety of daptomycin plus oxacillin (D/O) for persistent methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB). The results showed that D/O was an effective salvage regimen and may serve as a carbapenem-sparing option for persistent MSSAB.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Microbiology
Maged El-Ashker, Stefan Monecke, Mayada Gwida, Thoraya Saad, Adel El-Gohary, Amro Mohamed, Annett Reissig, Katrin Frankenfeld, Dominik Gary, Elke Mueller, Ralf Ehricht
Summary: This study aims to investigate the clonal diversity of Staphylococcus aureus strains in healthy dairy cattle, buffaloes, and their caretakers in the Nile Delta region of Egypt. The results reveal a high clonal diversity of multi-drug resistant S. aureus clones that colonize the animals and caretakers, indicating a potential health threat for both populations.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Ankit M. Gandhi, Megan D. Shah, Lindsay E. Donohue, Heather L. Cox, Joshua C. Eby
Summary: The study found that switching to cefazolin treatment in patients with suspected non-IgE-mediated HSR to nafcillin was safe, with 89% of patients completing cefazolin therapy and 10% not tolerating it. Among those who did not tolerate, 3 patients experienced unrelated reactions while 5 experienced the same reaction as attributed to nafcillin.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yueh-Ling Chen, Eugene Yu-Chuan Kang, Lung-Kun Yeh, David H. K. Ma, Hsin-Yuan Tan, Hung-Chi Chen, Kuo-Hsuan Hung, Yhu-Chering Huang, Ching-Hsi Hsiao
Summary: This study analyzed the clinical and molecular characteristics of MSSA ocular infections in Taiwan and compared them between CA and HA infections. CA-MSSA strains had a significantly higher rate of keratitis but a lower rate of conjunctivitis compared to HA-MSSA strains. Both CA-MSSA and HA-MSSA isolates were highly susceptible to various antibiotics.
Article
Microbiology
Robert Strengen Bigseth, Hakon Sandholdt, Andreas Petersen, Christian Ostergaard, Thomas Benfield, Louise Thorlacius-Ussing
Summary: This multicenter retrospective study evaluated the effect of empirical antimicrobial therapy on the clinical outcome of methicillin-susceptible Staphylococcus aureus bacteremia (MS-SAB). The study found no significant difference in mortality or relapse between patients treated with piperacillin-tazobactam or cefuroxime as empirical therapy for MS-SAB.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Tsai-Wen Wan, Yu-Jung Liu, Yu-Ting Wang, Yu-Tzu Lin, Jia-Chuan Hsu, Jui-Chang Tsai, Hao-Chieh Chiu, Po -Ren Hsueh, Wei-Chun Hung, Lee-Jene Teng
Summary: This study provides detailed genetic characterization of Tn6636, a multidrug-resistant mobile element, in clinical isolates of Staphylococcus aureus. The prevalence of Tn6636 in methicillin-susceptible S. aureus (MSSA) is higher than that in methicillin-resistant S. aureus (MRSA). The presence of this mobile element with various sequence types suggests its broad dissemination and the potential for continued spread of resistant plasmids.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Microbiology
Yu-Tzu Lin, Wei-Chun Hung, Tsai-Wen Wan, Hsin Li, Tai-Fen Lee, Po-Ren Hsueh, Lee-Jene Teng
Summary: A novel coagulase-negative Staphylococcus strain was isolated from human blood culture in Taiwan, identified as a new species named Staphylococcus taiwanensis, with distinct biological characteristics.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Infectious Diseases
Tsai-Wen Wan, Hiromitsu Mori, Wei-Chun Hung, Lee-Jene Teng, Tatsuo Yamamoto
Summary: The invasive CA-MRSA strain NN55 exhibits a novel interbacterial aggregate/net structure called SIAN, which may play an important role in its pathogenesis.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Ivan Evdokimov, Evgeny Papynov, Oleg Shichalin, Igor Afonin, Vladimir Apanasevich, Valeriy Tolmachev, Yuriy Krasnikov, Yuliya Gainullina, Galina Reva, Ivan Reva, Viktor Uso
Summary: The purpose of this study was to determine the regeneration ability of bone tissue using modern bioceramics synthesized through reactive spark plasma sintering. The study involved 26 female New Zealand White rabbits divided into two groups. X-ray densitometry was used to evaluate the regeneration of burr hole defects covered with bioceramic implants on days 7, 40, and 210 after surgery. The results showed tight fixation of the implants without dislocation, absence of osteoporosis and osteolysis in surrounding tissues, and the formation of dense bone tissue on the 210th day after surgery. The use of bioceramic implants allows for immediate closure of large bone defects and stimulation of dense bone formation.
Article
Medicine, General & Internal
Ivan Reva, Tatsuo Yamamoto, Ellada Slabenko, Marina Fleishman, Olga Lebedko, Mariya Tuchina, Viktoriya Semiglasova, Yuriy Krasnikov, Valeriy Tolmachev, Yuliya Gainullina, Galina Reva
Summary: The investigation of red bone marrow samples from deceased COVID-19 patients identified secondary hemophagocytosis. Phagocytic reactions in SARS-CoV-2-infected patients were found to affect both erythrocytes and leukocytes. These findings expand the understanding of COVID-19 pathogenesis and suggest new therapeutic measures to address the involvement of young erythrocytes and lymphocytes in the red bone marrow in the cascade of pathological reactions. The study also highlights the wide range of damaging effects of SARS-CoV-2 and its impact on multiple organ failure.
Article
Medicine, General & Internal
Ivan Reva, Tatsuo Yamamoto, Kirill Stegniy, Viktor Usov, Alexander Zolotov, Anatoliy Soroka, Natalya Struzkina, Ellada Slabenko, Pavel Zhibanov, Kseniya Porva, Galina Reva
Summary: The frequency of complications associated with cosmetic invasive interventions varies with age, gender, and location of skin lesions. In men, injuries are often related to burn injuries on the extremities, while complications of facial skin regeneration are more common in women aged 35 to 65 years, often due to the use of low-quality materials or a history of keloid scars.
Article
Medicine, General & Internal
Ivan Reva, Tatsuo Yamamoto, Kirill Stegniy, Viktor Usov, Alexander Zolotov, Anatoliy Soroka, Natalya Struzkina, Ellada Slabenko, Pavel Zhibanov, Kseniya Porva, Galina Reva
Summary: Pathological scarring lacks a clear explanation in terms of its cause, and it is characterized by the unpredictable and continuous growth of keloid scars, which do not regress for many years and are difficult to treat effectively. Research shows that the number of macrophages in keloid scars is reduced compared to areas of normal skin regeneration and hypertrophic scars, which may contribute to keloid scarring and connective tissue transformation.
Article
Medicine, General & Internal
Dmitrii Puga, Ivan Reva, Tatsuo Yamamoto, Svetlana Nikolaenko, Grachik Abramyan, Marina Fleishman, Anastasia Shindina, Konstantin Lonshakov, Tatiana Lemeshko, Anatoliy Soroka, Galina Reva
Summary: Using immunohistochemistry, this study explored the features of gender hormone receptors in the structure of the cervix mucous membrane epithelium in postmenopausal women and their relationship with keratinocyte proliferative activity. It demonstrated the significance of estrogen deficiency in proliferative activity and identified potential therapeutic targets for regulating and preventing neoplasia and malignancy in the cervical epithelium structure.
Article
Medicine, General & Internal
Ivan Reva, Tatsuo Yamamoto, Grachik Abramyan, Marina Fleishman, Olga Lebedko, Anastasia Shindina, Konstantin Lonshakov, Tatiana Lemeshko, Anatoliy Soroka, Galina Reva, Dmitriy Puga
Summary: This article analyzes the changes in immune cells and their quantity in the cervical mucous membrane of postmenopausal women using immunohistochemistry, and finds differences in immune representation in different parts of the mucous membrane.
Article
Medicine, General & Internal
Ivan Reva, Tatsuo Yamamoto, Kirill Stegniy, Ellada Slabenko, Viktoriya Semiglasova, Igor Sementsov, Olga Lebed'ko, Marina Fleishman, Aleksey Kudelya, Mariya Tuchina, Viktor Usov, Yuriy Krasnikov, Ekaterina Mozhilevskaya, Tatiana Lemeshko, Aleksey Novikov, Valeriy Tolmachev, Galina Reva
Summary: With the emergence of new SARS-CoV-2 strains, studying the cellular damage caused by the virus is crucial for vaccine development and treatment strategies. Research has shown that the red bone marrow of COVID-19 patients exhibits signs of stromal and parenchymal damage, as well as pathologic damage to erythropoiesis, providing valuable insights for targeted therapy.
Article
Medicine, General & Internal
Ivan Reva, Kirill Stegniy, Ekaterina Dvoinikova, Ekaterina Mozhilevskaya, Marina Fleischman, Stanislav Ichenko, Valeriy Tolmachev, Igor Sementsov, Ellada Slabenko, Dmitriy Zvyagintsev, Rodion Gorbarenko, Aleksandr Zolotov, Tamara Obydennikova, Galina Reva
Summary: The development of targeted treatment methods for inhibiting angiogenesis in malignant tissues is crucial for modern oncology. This study focuses on the expression characteristics of CD34-positive cells at the border of the tumor and malignant tissue. High expression of CD34-positive cells in small and large vessels correlates with tumor size and disease age during malignancy. VEGF, the main regulator of angiogenesis during tissue malignancy, presents a promising target for targeted treatment.
Article
Medicine, General & Internal
Evgeniy Martynenko, Tamara Obydennikova, Kirill Stegniy, Ivan Reva, Marina Fleischman, Aleksandr Zolotov, Dmitriy Zvyagintsev, Sergey Terekhov, Olga Lebedko, Igor Sementsov, Ellada Slabenko, Galina Reva, Viktor Usov
Summary: This study aimed to optimize the timing of autodermoplasty in the treatment of burns by developing morphological criteria. The results showed that the optimal time for autodermoplasty is 7-8 days after thermal injury, while transplantation after 14 days is less effective.
Article
Microbiology
Yu-Tsung Huang, Yao-Wen Kuo, Nan-Yao Lee, Ni Tien, Chun-Hsing Liao, Lee-Jene Teng, Wen-Chien Ko, Po-Ren Hsueh
Summary: Detection of carbapenemase-producing Enterobacterales is important for therapeutic decisions and infection control. The Xpert CARBA-R and NG-Test CARBA 5 assays showed high sensitivity and specificity in detecting carbapenemases in carbapenem-resistant Enterobacterales isolates.
MICROBIOLOGY SPECTRUM
(2022)
