期刊
COMPTES RENDUS PHYSIQUE
卷 10, 期 8, 页码 751-763出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crhy.2009.10.002
关键词
Red blood cell; Deformability; Microcapillary; Microfluidics
资金
- Italian Ministry of Research
- Regione Campania
- BIOMICS - Biomimetic and Cellular Systems ESA
The high red blood cell (RBC) deformability is essential to optimal gas exchange between gas and tissues in microcirculation in vivo. This review is focused on the flow behavior of RBCs in microconfined geometries in vitro, such as circular section capillaries, rectangular channels and pores, where at least one transverse dimension is comparable to cell size. Experimental results on RBC velocity and shape are reviewed together with modeling predictions and numerical simulations. In spite of the progress made so far, the pathophysiological implications of altered RBC deformability are still to be fully elucidated, and more data from clinically-relevant experimental methods and modeling-based interpretation are needed. Future directions include the emerging application of microfluidics techniques to investigate RBC flow in complex geometries. To cite this article: S. Guido, G. Tomaiuolo, C. R. Physique 10 (2009). (C) 2009 Published by Elsevier Masson SAS on behalf of Academie des sciences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据