Article
Pharmacology & Pharmacy
Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Recent research indicates that BCP, through its action on CB2 receptors and other mechanisms, can effectively reduce METH reward and intake, as well as motivation to seek and take METH. Additionally, BCP also inhibits METH-enhanced electrical BSR, and blocks METH-primed and cue-induced reinstatement of drug-seeking behavior.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ginna Uruena-Mendez, Andrea Dimiziani, Lidia Belles, Raphael Goutaudier, Nathalie Ginovart
Summary: Current research suggests that alterations in dopamine transmission in the striatum contribute to impulsivity and novelty-seeking, and may be related to a higher susceptibility to drug abuse. However, there is still debate about whether this susceptibility results from a hyperdopaminergic or hypodopaminergic state. In this study, rats with high impulsivity and novelty-seeking behaviors exhibited lower availability of D2/3 receptors and higher amphetamine-induced dopamine release in the striatum, which predicted higher levels of cocaine intake. Cocaine self-administration did not affect D2/3 receptor availability or impulsivity in these rats. Importantly, cocaine exposure led to a baseline-dependent decrease in stimulated dopamine release in high-impulsive/high novelty-seeking rats only, and to a baseline-dependent increase in novelty-seeking in low-impulsive/low novelty-seeking rats only. Overall, this study suggests that susceptibility to drug abuse is associated with an innate hyper-responsive dopamine system that promotes impulsive and novelty-seeking behaviors, and leads to stronger initial drug-reinforcing effects. However, with repeated cocaine use, tolerance to drug-induced dopamine elevations develops, resulting in compensatory increases in drug consumption to overcome reduced reward effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Lidia Belles, Andrea Dimiziani, Stergios Tsartsalis, Philippe Millet, Francois R. Herrmann, Nathalie Ginovart
Summary: The study revealed a strong relationship between impulsivity and novelty preference in rats. The availability of D2/3 receptors in the striatum is closely associated with these traits, while dopamine release in both ventral and dorsal striatum further impacts this correlation.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Dayang Nooreffazleen Yahya, Rhanye Mac Guad, Yuan-Seng Wu, Siew Hua Gan, Subash C. B. Gopinath, Hasif Adli Zakariah, Rusdi Abdul Rashid, Maw Shin Sim
Summary: The rs4755404 gene polymorphism of SLC1A2 is significantly associated with METH-induced psychosis, especially for individuals with the GG homozygous genotype.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yongsheng Zhu, Kejia Wang, Tengfei Ma, Yuanyuan Ji, Yin Lou, Xiaoyu Fu, Ye Lu, Yige Liu, Wei Dang, Qian Zhang, Fangyuan Yin, Kena Wang, Bing Yu, Hongbo Zhang, Jianghua Lai, Yunpen Wang
Summary: This study identified neural pathways involved in controlling depressive-like behaviors and acute withdrawal symptoms after morphine withdrawal. Furthermore, a new DBS treatment protocol was developed to reverse abnormal plasticity and alleviate withdrawal symptoms and depressive-like behaviors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Neurosciences
Paolo Scacchia, Micaela Lucarelli, Maria Teresa Fiorenza, Sonia Canterini, Vilfredo De Pascalis
Summary: The Val(158) Met polymorphism of the COMT gene was found to be significantly associated with the disorderliness facet of novelty seeking, and this association was moderated by sex, showing a sex-specific influence on gene-behavior associations. No significant genotype effect was found for males, and there was no significant effect of the COMT gene on attention and hypnotic suggestibility measures.
NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Beibei Peng, Qikuan Xu, Jing Liu, Sophie Guo, Stephanie L. Borgland, Shuai Liu
Summary: The study found that chronic corticosteroid treatment induces anxiety-like behavior and impairs food-seeking behavior. Additionally, chronic CORT treatment decreases excitability and excitatory synaptic transmission onto VTA dopamine neurons, while increasing somatodendritic dopamine concentration. Restoring D2R signaling in the VTA can ameliorate these deficits induced by chronic CORT exposure.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Daniel J. Torres, Jordan T. Yorgason, Catherine C. Mitchell, Ayaka Hagiwara, Marilou A. Andres, Suguru Kurokawa, Scott C. Steffensen, Frederick P. Bellinger
Summary: Selenium is important in mitigating methamphetamine-induced neurotoxicity, and SELENOP1 plays a direct role in dopamine signaling, affecting the dopaminergic response. SELENOP1 KO mice exhibited abnormal response to methamphetamine, which was attenuated by SELENOP1 through a selenium-independent mechanism involving SELENOP1-ApoER2 interaction to promote D2R function.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Robert Ranaldi, Patrick Timken, Daleya Parasram, Tasmia Ali, Sixue Zhang, Omar Moukha-Chafiq, Corinne Augelli-Szafran, John M. Streicher
Summary: There is currently no FDA-approved medication for methamphetamine use disorder. The translation of dopamine D3 receptor antagonists as a potential treatment has been hindered due to their ability to raise blood pressure to dangerous levels. This study presents the effects of SR 21502, a selective D3 receptor antagonist, on cue-induced reinstatement of methamphetamine-seeking in rats. The results show that SR 21502 significantly reduces cue-induced reinstatement, suggesting it may be a promising pharmacotherapeutic agent for methamphetamine or other drug use disorders.
NEUROSCIENCE LETTERS
(2023)
Article
Behavioral Sciences
Wiebke Herrmann, Jan Wacker
Summary: The study suggests a relationship between agentic extraversion and executive functions due to shared influences of individual differences in the dopamine system, particularly for tasks like 3-back and switching. However, it was found that some of this association is partly due to shared dopamine-based processes among tasks, indicating that variance components and measurement difficulties of EF tasks should be considered when investigating personality-related individual differences in EFs.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Quenten Highgate, Afnan Al Abadey, Susan Schenk
Summary: This study found that repeated administration of the dopamine D2 receptor antagonist eticlopride can increase D2 receptor expression and improve behavioral flexibility. Additionally, eticlopride treatment can reverse the reversal learning impairment caused by methamphetamine exposure.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
David W. Greening, Michael Notaras, Maoshan Chen, Rong Xu, Joel D. Smith, Lesley Cheng, Richard J. Simpson, Andrew F. Hill, Maarten van den Buuse
Summary: Studies have shown that chronic Meth abuse can lead to psychotic episodes resembling schizophrenia, with Brain-derived neurotrophic factor (BDNF) playing a crucial role in this process. Research on transgenic mice revealed that BDNF genetic variation significantly influences the long-term brain changes induced by Meth, indicating that drug-induced psychosis may be modulated at the molecular level by a single genetic locus.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Samuel Hogarth, Emily J. Jaehne, Xiangjun Xu, Quenten Schwarz, Maarten van den Buuse
Summary: The aim of this study was to investigate the role of BDNF and dopamine D3 receptors in the effects of chronic methamphetamine on prepulse inhibition (PPI), an endophenotype of psychosis. The results showed that chronic methamphetamine disrupted PPI regulation in male mice with BDNF haploinsufficiency, regardless of D3 receptor knockout. However, there were no effects of BDNF heterozygosity or D3 knockout on PPI regulation in female mice. These findings suggest a significant involvement of BDNF in the long-term effects of methamphetamine on PPI, particularly in male mice.
Article
Neurosciences
Nicholas A. Everett, Anita J. Turner, Priscila A. Costa, Sarah J. Baracz, Jennifer L. Cornish
Summary: The study found that peripherally administered oxytocin has inhibitory effects on METH self-administration and reinstatement, with a requirement for vagus nerve signaling involvement, and that this vagal dependency is partially mediated by sex and drug withdrawal.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Huan Liu, Wei Zhang, Xiao-Dong Deng, Ying Ma, Yun Liu
Summary: The study showed that the NQO1 gene may play a significant role in the pathophysiological process of METH dependence, and the 609C/T polymorphism may contribute to the susceptibility to METH dependence in the Chinese Han population.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Psychiatry
Wei Ai, William A. Cunningham, Meng-Chuan Lai
Summary: This study aimed to examine the engagement and theoretical drivers of camouflaging behavior in the general population. The findings revealed a similar dimensional structure of camouflaging behavior in the general population compared to previous studies on autism. Social motivational factors, such as social comparison, public self-consciousness, internalized social stigma, and social anxiety, were identified as significant predictors of camouflaging behavior. These findings highlight the shared social coping experience of camouflaging in the general population, including autistic individuals.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Nina Bruinhof, Ela Sehic, Gregory R. Hancock, Maria A. Gartstein, Carolina de Weerth
Summary: The psychometric evaluation of the Baby-PAWS questionnaire in a Dutch sample showed good validity, with a four-factor structure different from the original evaluation in the American sample. American women scored higher on the Baby-PAWS items than Dutch women. These results highlight cross-cultural differences in perinatal mental health and stress the importance of examining instrument structure of context-dependent constructs.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Noham Wolpe, Aya Vituri, Peter B. Jones, Moni Shahar, Emilio Fernandez-Egea
Summary: This study found that the MAP and EE negative symptom dimensions in patients with treatment-resistant schizophrenia are independent and stable over time, with common causes of secondary negative symptoms clustering in the MAP dimension.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Psychiatry
Cristina Vintro-Alcaraz, Gemma Mestre-Bach, Roser Granero, Monica Gomez-Pena, Laura Moragas, Fernando Fernandez-Aranda, Marc N. Potenza, Susana Jimenez-Murcia
Summary: This study found differences between patients with gambling disorder (GD) with and without self-reported ADHD symptoms in terms of psychopathology, personality, and treatment outcomes. Patients with self-reported ADHD symptoms were more severe in their GD and experienced more severe relapses following treatment. Therefore, more vigilant follow-up and interventions are needed for patients with this comorbidity.
COMPREHENSIVE PSYCHIATRY
(2024)