Pharmacological Inhibition of Protein Lipidation

Targeting protein palmitoylation: selective inhibitors and implications in disease

(2014) Burzin Chavda et al.   Expert Opinion on Drug Discovery

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors

(2014) Jennie A. Hutton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

PalmPred: An SVM Based Palmitoylation Prediction Method Using Sequence Profile Information

(2014) Bandana Kumari et al.   PLoS One

Profiling Targets of the Irreversible Palmitoylation Inhibitor 2-Bromopalmitate

(2013) Dahvid Davda et al.   ACS Chemical Biology

Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling

(2013) Shu-Ping Song et al.   BIOCHEMICAL JOURNAL

Covalent lipid modifications of proteins

(2013) Marilyn D. Resh   CURRENT BIOLOGY

Oligomerization of DHHC ProteinS-Acyltransferases

(2013) Jianbin Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Bromopalmitate Analogues as Activity-Based Probes To Explore Palmitoyl Acyltransferases

(2013) Baohui Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

(2013) Elissaveta Petrova et al.   Nature Chemical Biology

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

(2012) Catherine A. McLellan et al.   ACS Chemical Biology

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

(2012) Yusuke Ohno et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence suggesting that ghrelin O-acyl transferase inhibitor acts at the hypothalamus to inhibit hypothalamo-pituitary-adrenocortical axis function in the rat

(2012) Marcin Rucinski et al.   PEPTIDES

Proteomic Analysis of S-Acylated Proteins in Human B Cells Reveals Palmitoylation of the Immune Regulators CD20 and CD23

(2012) Corinne Ivaldi et al.   PLoS One

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

(2012) L. B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

(2012) Andrew S. Bell et al.   PLoS Neglected Tropical Diseases

Proteomic analysis of protein palmitoylation in adipocytes

(2012) Wenying Ren et al.   Adipocyte

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective and programmed cleavage of GPI-anchored proteins from the surface membrane by phospholipase C

(2011) Alexandra Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bioorthogonal chemical tagging of protein cholesterylation in living cells

(2011) William P. Heal et al.   CHEMICAL COMMUNICATIONS

Exploring Protein Lipidation with Chemical Biology

(2011) Howard C. Hang et al.   CHEMICAL REVIEWS

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes

(2011) Xinxin Gao et al.   FEBS LETTERS

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

(2011) Jennifer Greaves et al.   TRENDS IN BIOCHEMICAL SCIENCES

Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts

(2010) Ilya Levental et al.   BIOCHEMISTRY

Small molecule inhibition of protein depalmitoylation as a new approach towards downregulation of oncogenic Ras signalling

(2010) Frank J. Dekker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Palmitoylation of oncogenic NRAS is essential for leukemogenesis

(2010) B. Cuiffo et al.   BLOOD

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells

(2010) K. M. Sane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Palmitoylome profiling reveals S-palmitoylation–dependent antiviral activity of IFITM3

(2010) Jacob S Yount et al.   Nature Chemical Biology

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans

(2009) C. Morck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

(2008) Benjamin C. Jennings et al.   JOURNAL OF LIPID RESEARCH

CSS-Palm 2.0: an updated software for palmitoylation sites prediction

(2008) J. Ren et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson–Gilford progeria syndrome mutation

(2007) S YANG   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS