Article
Food Science & Technology
Zhiqiang Wang, Zhaoyang Wu, Guanglei Zuo, Soon Sung Lim, Hongyuan Yan
Summary: The study found that defatted seeds of Oenothera biennis (DSOB) have excellent antioxidant, alpha-glucosidase inhibition, and aldose reductase inhibition properties, high content of polyphenols, carbohydrates, proteins, and minerals, making it suitable as an ingredient for functional foods for diabetes.
Article
Agricultural Engineering
Christoph Kornpointner, Aitor Sainz Martinez, Silvija Marinovic, Christian Haselmair-Gosch, Polona Jamnik, Katharina Schro, Christian Lo, Heidi Halbwirth
Summary: This study investigated the secondary metabolite composition and antioxidant activities of hemp roots from three chemovars, revealing the presence of five triterpenes, ten phytosterols, and five aliphatic compounds in the root extracts. Some compounds, such as glutinol, beta-amyrone, and stigmastanol, were identified for the first time in cannabis roots. The predominant triterpenoids friedelin and epifriedelinol were quantified, showing dependence on different factors like chemovar, harvest times, drying conditions, and extraction methods.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Food Science & Technology
Bohuslava Tremlova, Hana Koudelkova Mikulaskova, Klaudia Hajduchova, Simona Jancikova, Dominika Kaczorova, Sanja Cavar Zeljkovic, Dani Dordevic
Summary: The study investigated the impact of different growth stages of hemp plants on their chemical composition and antioxidant activity, revealing significant differences in samples between stages. Pre-flowering is optimal for harvesting hemp for high polyphenolic content, while flowering stage is ideal for harvesting for high cannabinoid and terpenoid levels.
Article
Engineering, Chemical
Tae Heon Kim, Woo Jung Kim, Soon Yeong Park, Hoon Kim, Dae Kyun Chung
Summary: The study showed that Oenothera biennis sprout extract (OBS-E) has antioxidant, anti-wrinkle, and moisturizing activities, with polyphenolic acids and flavonoid glycosides playing key roles in these effects. OBS-E significantly increased hyaluronic acid levels and the expression of moisturizing genes, leading to improved skin hydration.
Article
Plant Sciences
Kelly F. Boddington, Eric Soubeyrand, Kristen Van Gelder, Jose A. Casaretto, Colby Perrin, Taylor J. B. Forrester, Cameron Parry, M. Sameer Al-Abdul-Wahid, Nicholas G. Jentsch, Jakob Magolan, Gale G. Bozzo, Matthew S. Kimber, Steven J. Rothstein, Tariq A. Akhtar
Summary: This study identifies a set of enzymes in Cannabis involved in the biosynthesis of bibenzyls, contributing valuable insights for the rational metabolic engineering of natural product therapeutics.
Article
Pharmacology & Pharmacy
Veronica Cocetta, Paolo Governa, Vittoria Borgonetti, Mattia Tinazzi, Gregorio Peron, Daniela Catanzaro, Massimiliano Berretta, Marco Biagi, Fabrizio Manetti, Stefano Dall'Acqua, Monica Montopoli
Summary: The relevance and incidence of intestinal bowel diseases (IBD) have been increasing over the last 50 years and the current therapies are characterized by severe side effects, making essential the development of new strategies that combine efficacy and safety in the management of human IBD. Herbal products are highly considered in research aimed at discovering new approaches for IBD therapy and, among others, Cannabis sativa L. has been traditionally used for centuries as an analgesic and anti-inflammatory remedy also in different gastrointestinal disorders. This study aims to investigate the effects of different C. sativa isolated compounds in an in vitro model of intestinal epithelium. The ability of treatments to modulate markers of intestinal dysfunctions was tested on Caco-2 intestinal cell monolayers. Our results, obtained by evaluation of ROS production, TEER and paracellular permeability measurements and tight junctions evaluation show Cannabidiol as the most promising compound against intestinal inflammatory condition. Cannabidiol is able to inhibit ROS production and restore epithelial permeability during inflammatory and oxidative stress conditions, suggesting its possible application as adjuvant in IBD management.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Claudia Muscara, Antonella Smeriglio, Domenico Trombetta, Giuseppina Mandalari, Erminia La Camera, Gianpaolo Grassi, Clara Circosta
Summary: This study evaluated the phytochemical profile, antioxidant, and antimicrobial properties of two standardized extracts rich in cannabidiol from non-psychotropic Cannabis sativa L. The extracts showed strong antioxidant and concentration-dependent antimicrobial activities, suggesting potential applications as novel antimicrobial agents.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Applied
Barbara Farinon, Lara Costantini, Romina Molinari, Giacomo Di Matteo, Stefania Garzoli, Serena Ferri, Brunella Ceccantoni, Luisa Mannina, Nicolo Merendino
Summary: The study showed that malting can increase protein content and improve antioxidant properties of hempseeds, while maintaining fat content and fatty acid profile. Kilning at 70 degrees Celsius was effective in reducing trypsin inhibitors and enhancing antioxidant capacity. Therefore, malting with 3 days of germination and kilning at 70 degrees Celsius could be a suitable process for enhancing hempseeds quality.
Review
Biochemistry & Molecular Biology
Xiangping Sun
Summary: Cannabis is an ancient cultivated plant with economic value and has less than 0.3% tetrahydrocannabinol (THC). China is the largest producer and exporter of cannabis with a long history of cultivation. Research has focused on the chemical components of cannabis, especially phenolic compounds.
Article
Plant Sciences
Ramona Fecker, Ioana Zinuca Magyari-Pavel, Ileana Cocan, Ersilia Alexa, Iuliana Maria Popescu, Adelina Lombrea, Larisa Bora, Cristina Adriana Dehelean, Valentina Buda, Roxana Folescu, Corina Danciu
Summary: This study evaluated the oxidative stability and protective effect of a mixture of Helianthus annuus L. and Oenothera biennis L. oils on 3D tissue models. The results showed that the mixture had good oxidative stability and did not cause skin irritation or phototoxicity.
Article
Food Science & Technology
Chaymae Benkirane, Farid Mansouri, Abdessamad Ben Moumen, Yassine Taaifi, Reda Melhaoui, Hana Serghini Caid, Marie-Laure Fauconnier, Ahmed Elamrani, Malika Abid
Summary: This study aimed to analyze the phenolic compounds and antioxidant power of hemp seeds grown in northern Morocco. A total of 33 phenolic compounds were identified, with N-trans-caffeoyltyramine, cannabisin A, and cannabisin B being the most abundant. The antioxidant activities varied among different tests, and the geographical location and genotype played significant roles in determining the phenolic compounds' content. Hemp seeds from Jebha and Galaz regions exhibited higher levels of phenolic compounds and stronger antioxidant activity compared to Tamorot and Ratba regions. This characterization provides valuable information for breeders in developing new hemp varieties.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agricultural Engineering
Nadav Danziger, Nirit Bernstein
Summary: Light plays a crucial role in affecting plant growth, metabolism, and function, with different light spectra impacting plant yield, chemical profiles, and morphology, especially in relation to cannabinoid metabolism in cannabis plants.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Matej Malik, Jiri Velechovsky, Lukas Praus, Anezka Janatova, Zdenka Kahankova, Pavel Kloucek, Pavel Tlustos
Summary: There is increasing evidence that nutrients and biostimulants play a role in plant secondary metabolism. This study examined the effects of amino acid-based supplements on the cannabinoid and terpene profiles of medical cannabis plants. The results showed that amino acid biostimulation influenced ion levels in plant tissues and had different effects on nutrient cycles.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Laura Serventi, Giancarlo Angeles Flores, Gaia Cusumano, Davide Barbaro, Bruno Tirillini, Roberto Venanzoni, Paola Angelini, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, Gokhan Zengin, Luigi Menghini, Claudio Ferrante
Summary: This study focuses on the biological and medical potentials of hydroalcoholic extracts from different parts of the Cannabis sativa plant, specifically the leaves and inflorescences. The extracts showed strong antioxidant and antimicrobial effects, with particular efficacy against Escherichia coli and Bacillus subtilis. This could be attributed to the presence of benzoic acid and cannabidiolic acid in the extracts.
Article
Biochemistry & Molecular Biology
Anna Stasilowicz-Krzemien, Szymon Sip, Piotr Szulc, Judyta Cielecka-Piontek
Summary: Cannabis leaves contain a range of antioxidants that offer health benefits, and utilizing them can be cost-effective. This study aimed to assess the antioxidant activity of hemp leaves from different cultivars and analyze their cannabinoid profiles. The choice of extractant and extraction conditions significantly influenced the extraction efficiency and antioxidant activity of the active compounds. Ultrasonic-assisted extraction using methanol yielded the highest cannabinoid profile and antioxidant potential in Bialobrzeska leaf extracts.
Review
Medicine, Research & Experimental
Shaho Ghahremani Dehbokri, Nazila Alizadeh, Alireza Isazadeh, Amir Baghbanzadeh, Soheil Abbaspour-Ravasjani, Khalil Hajiasgharzadeh, Behzad Baradaran
Summary: Breast cancer is a prevalent and deadly disease, and its incidence rate is increasing globally. Conventional treatment approaches, such as surgery, radiation therapy, and chemotherapy, often yield unsatisfactory outcomes. Therefore, developing innovative strategies, such as immunotherapy, is crucial for effective breast cancer therapy. The blockade of immune checkpoints, particularly cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), has shown promising results in cancer immunotherapy. The use of anti-CTLA-4 antibodies alone or in combination with other therapeutic agents enhances the tumor-suppressive effects of the immune system and improves cancer prognosis. Immune checkpoint inhibitors hold great potential for breast cancer treatment. This review discusses the role of CTLA-4 and its therapeutic potential in breast cancer therapeutics.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Monireh Khordadmehr, Hamed Ezzati, Amirali Shahbazfar, Farinaz Jigari-Asl, Behzad Baradaran, Elham Baghbani, Saeed Noorolyai
Summary: The overexpression of miR-451a can enhance the chemosensitivity of breast cancer cells to carboplatin therapy, which may provide a beneficial strategy for future cancer therapy.
PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fahimeh Zahednezhad, Parvin Zakeri-Milani, Javid Shahbazi Mojarrad, Muhammad Sarfraz, Mohammad Mahmoudian, Behzad Baradaran, Hadi Valizadeh
Summary: This study investigates the cellular uptake and cytotoxicity of surface-modified cisplatin (CisP) loaded liposomes in macrophage and cancer cells. Modified/un-modified liposomes were prepared and characterized for various properties. The results show that the modified liposomes demonstrate higher cellular uptake and increased cytotoxicity in the studied cells. Acetyl carnitine modification of CisP-liposomes can be considered an effective approach for increasing cellular uptake and cytotoxicity in cancer and macrophage cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Clinical Neurology
Ashkan Mowla, Banafsheh Shakibajahromi, Shima Shahjouei, Humain Baharvahdat, Ali Amini Harandi, Farzad Rahmani, Stefania Mondello, Nasrin Rahimian, Achille Cernigliaro, Elyar Sadeghi Hokmabadij, Seyed Amir Ebrahimzadeh, Mahtab Ramezani, Kaveh Mehrvar, Mehdi Farhoudi, Soheil Naderi, Shahab Mahmoudnejad Fenderi, Masoud Pishjoo, Orkhan Alizada, Francisco Purroy, Manuel Requena, Georgios Tsivgoulis, Ramin Zand
Summary: Infection with SARS-CoV-2 may be associated with increased odds of in-hospital mortality in patients with intracerebral hemorrhage (ICH). SARS-CoV-2 infected ICH patients are younger, have higher ICH scores, more frequent history of diabetes, and lower platelet counts.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nazanin Jalali, Elyar Sadeghi Hokmabadi, Abdoreza Ghoreishi, Payam Sariaslan, Shahram Rafie, Afshin Borhani-Haghighi, Amir Moghadam Ahmadi, Hossein Azin, Alireza Vakilian, Parvin Khalili, Mehdi Farhoudi
Summary: This descriptive research analyzed the vascular territory and treatment outcomes in Iranian intravenous thrombolysis ischemic stroke patients based on data from the SITS registry. The results showed no significant association between vascular territory and mortality, functional independence, or brain hemorrhage occurrence. Age, diabetes, NIHSS score, and admission duration were identified as important predictors of three-month mortality, excellent outcome, and functional independence.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Samane Abbasi, Milad Asghari Totmaj, Masoumeh Abbasi, Saba Hajazimian, Pouya Goleij, Javad Behroozi, Behrouz Shademan, Alireza Isazadeh, Behzad Baradaran
Summary: Over the last decade, novel therapeutic approaches like CAR-T-cell immunotherapy have transformed the treatment perspective of human malignancies. However, this therapy is associated with side effects and faces challenges in manufacturing, engineering, applications, and toxicities. Further studies are needed to enhance efficacy and minimize adverse events.
Review
Oncology
Zanyar HajiEsmailpoor, Peyman Tabnak, Behzad Baradaran, Fariba Pashazadeh, Leili Aghebati-Maleki
Summary: The purpose of this study was to evaluate the diagnostic performance of computed tomography (CT) scan-based radiomics in predicting lymph node metastasis (LNM) in gastric cancer (GC) patients. The results showed that there were differences in sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) between radiomics models and combined models. Subgroup analysis also found that different CT scan phases, regions of interest (ROIs), and segmentation methods had an impact on diagnostic accuracy. In conclusion, CT scan-based radiomics approach has the potential to predict LNM in GC patients preoperatively as a non-invasive diagnostic tool.
FRONTIERS IN ONCOLOGY
(2023)
Review
Multidisciplinary Sciences
Omid Rahbar Farzam, Niloofar Mehran, Farzaneh Bilan, Ehsan Aghajani, Reza Dabbaghipour, Ghazale Asemani Shahgoli, Behzad Baradaran
Summary: Colorectal cancer, a common malignancy with high mortality, can be effectively treated using imaging-guided photothermal therapy combined with nanotechnology. This approach minimizes side effects and improves treatment outcomes, making it significant for colorectal cancer treatment.
Article
Rheumatology
Roghayeh Tofigh, Mohammadali Hosseinpourfeizi, Reza Safaralizadeh, Sepideh Ghoddusifar, Behzad Baradaran
Summary: This study identifies NEAT1, GAS5, and GAPLINC as promising serological biomarkers in rheumatoid arthritis (RA). The reduced expression of NEAT1 and GAS5 suggests their potential roles as diagnostic and prognostic markers, while the significantly elevated average expression of GAPLINC in RA patients' serum samples indicates its potential as a biomarker candidate for disease stratification. TMEVPG1, on the other hand, displayed unaltered expression levels in RA samples.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Article
Biology
Rozhin Dabbaghi, Reza Safaralizadeh, Shima Rahmani, Nesa Barpour, Mohammadali Hosseinpourfeizi, Ali Rajabi, Behzad Baradaran
Summary: This study investigates the role of T-bet, IFN-gamma, and MEG3 in the pathogenesis of multiple sclerosis (MS) and their potential as diagnostic and therapeutic targets. The results show that T-bet expression is elevated in treatment-naive relapsing-remitting MS (RRMS) patients compared to healthy individuals. RRMS patients treated with different disease modifying therapies (DMTs) exhibit downregulated T-bet and MEG3 expression levels, with more pronounced effects in females. The correlation between T-bet and MEG3 and between IFN-gamma and T-bet is observed in healthy individuals, while a strong positive correlation is found between MEG3 and IFN-gamma in RRMS patients treated with Glatiramer Acetate (GA). Remarkably, RRMS patients treated with Dimethyl Fumarate (DMF) show a significant positive correlation between T-bet and MEG3. These findings suggest the diagnostic potential of T-bet in RRMS and indicate the need for further exploration of the interplay between MEG3, T-bet, and IFN-gamma in RRMS patients.
BMC RESEARCH NOTES
(2023)
Article
Immunology
Ali Sayadmanesh, Vahid Yekehfallah, Amir Valizadeh, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Mohsen Basiri, Behzad Baradaran
Summary: CAR T cell therapy has shown promising efficacy in patients with hematologic malignancies, but it also presents potential toxicity and adverse effects. This study focuses on the unexpected side effects of targeting normal host tissues and discusses recent safety strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Farid Mostafaei, Somayeh Mahdinloo, Hadi Valizadeh, Salar Hemmati, Mahdieh Abdi, Muhammad Sarfraz, Behzad Baradaran, Parvin Zakeri-Milani
Summary: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, usually diagnosed in advanced stages. Chemotherapy is commonly used to treat advanced liver cancer but faces challenges that reduce its effectiveness. This review discusses the prevalence, staging, and treatment methods for liver cancer. It also explores recent studies on smart drug- and gene-delivery systems designed specifically for HCC, aiming to improve treatment efficacy.
Review
Oncology
Najibeh Shekari, Dariush Shanehbandi, Tohid Kazemi, Habib Zarredar, Behzad Baradaran, Seyed Amir Jalali
Summary: This article summarizes current evidence on V-domain immunoglobulin suppressor of T cell activation (VISTA), its related ligands, their interactions and effects, as well as preclinical and clinical targeting agents. Investigating VISTA ligands helps understand their functions and roles, and may facilitate the discovery of alternative therapeutic approaches targeting the VISTA pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Genetics & Heredity
Masoumeh Hajizadeh, Farnaz Hajizadeh, Sevil Ghaffarei, Mohammad Amin Doustvandi, Khadijeh Hajizadeh, Seyyed Mohammad Yaghoubi, Fateme Mohammadnejad, Nadia Allahyarzadeh Khiabani, Pegah Mousavi, Behzad Baradaran
Summary: This review summarizes the role and potential efficacy of miRNAs in promoting and inhibiting cell proliferation and apoptosis in HCC, as well as the role of miRNAs in therapy resistance in HCC.
Article
Medicine, Research & Experimental
Maryam Tohidast, Neda Memari, Mohammad Amini, Seyed Samad Hosseini, Asiyeh Jebelli, Mohammad Amin Doustvandi, Behzad Baradaran, Ahad Mokhtarzadeh
Summary: This study demonstrates that the combination of miR-145 and paclitaxel can inhibit cell proliferation and migration in prostate cancer cells, and enhance chemosensitivity. This combination therapy may be a promising approach for the treatment of prostate cancer.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)