Review
Food Science & Technology
Muhammad Umar, Uracha Ruktanonchai, Davids Makararpong, Anil Kumar Anal
Summary: Colostrum, the first milk produced by lactating mammals, contains bioactive proteins that are crucial for the development of neonates' passive immune system. The glycosylation pattern of these proteins changes with lactations, and understanding this pattern can help us understand the pathogenic inhibitory activity of these proteins.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Rahul Mehra, Rajat Singh, Varij Nayan, Harpal S. Buttar, Naveen Kumar, Shiv Kumar, Anuradha Bhardwaj, Ravinder Kaushik, Harish Kumar
Summary: Bovine colostrum is a highly concentrated supplement with potential benefits for preventing and managing a variety of health issues. Its components have shown promise in nutraceuticals and non-pharmacological therapies, influencing the immune system, gastrointestinal tract, and bone marrow stem cells.
Article
Chemistry, Applied
Fabian Ostertag, Christian M. Schmidt, Sonja Berensmeter, Joerg Hinrichs
Summary: A RP-HPLC-DAD method was developed and validated for the simultaneous quantification of minor and major whey proteins, with high precision and accuracy demonstrated in the validation experiments.
Article
Agriculture, Dairy & Animal Science
Oleksandra Pryshchepa, Gulyaim Sagandykova, Joanna Rudnicka, Pawel Pomastowski, Myroslav Sprynskyy, Boguslaw Buszewski
Summary: One trend in the modern world is the search for biologically active substances based on renewable resources. Milk proteins can be a solution for this, as they have long been known as compounds that can be used to manufacture various food and non-food products. This study aimed to investigate the parameters of Zn-bovine lactoferrin (bLTF) interactions and the synthesis of Zn-rich protein complexes. The results showed that the pH, ionic strength, and concentration of Zn2+ significantly affected the Zn-bLTF interactions.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Food Science & Technology
Thao M. Ho, Bhesh R. Bhandari, Nidhi Bansal
Summary: Factors such as protein content, processing conditions, and foaming methods have a significant impact on the foam quality of dairy products, particularly in terms of their appearance, texture, and stability. This review comprehensively discusses the functionality of milk proteins in producing and stabilizing foam under the influence of these factors, highlighting the challenges faced by researchers and the dairy industry in controlling the foaming process of milk for specific applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Valentina Gallo, Francesco Giansanti, Alyexandra Arienzo, Giovanni Antonini
Summary: Native and chemically modified whey proteins and their peptide derivatives have various properties, ranging from antimicrobial to immunological and antitumorigenic, which make them potentially useful in a wide range of treatment and prevention strategies. Whey proteins have been found to have antiviral actions against different types of viruses, including SARS-CoV-2. Currently, there are several studies investigating the efficacy of whey proteins, particularly lactoferrin, in human health, specifically in the prevention and treatment of SARS-CoV-2 infection.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Fisheries
Wang-Jing Liu, Yun-Shiang Chang, Kou-Chun Tseng, Meng-Hua Yu
Summary: White spot syndrome virus (WSSV) is a prominent pathogen in shrimp farming worldwide. However, there is currently no effective treatment for this virus. In this study, the antiviral properties of bovine lactoferrin (bLF) against WSSV were investigated, and it was found that bLF treatment significantly reduced shrimp mortalities caused by WSSV infection. The ability of bLF to bind to both host cells and WSSV virions suggests its potential as an anti-WSSV agent in shrimp culture, and the identified interaction proteins may play a role in WSSV infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Food Science & Technology
Eva Krolitzki, Sebastian P. Schwaminger, Moritz Pagel, Fabian Ostertag, Jorg Hinrichs, Sonja Berensmeier
Summary: Lactoferrin, a versatile protein found in mammals, is primarily isolated from bovine milk or sweet whey for industrial production and consumer goods applications. Established industrial productions focus on skim milk, but alternative approaches utilizing dairy by-products are also able to produce high-quality lactoferrin.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Chemistry, Applied
Marta Tomczynska-Mleko, Katsuyoshi Nishinari, Stanislaw Mleko, Konrad Terpilowski, Salvador Perez-Huertas
Summary: Whey protein isolate dispersions (9.5% protein) with 1.5% sugar (glucose, mannose, or xylose) were pre-heated and subjected to ions-induced gelation in an ultrasound environment. Sonication affected the rheological properties of gels and altered their surface hydrophilicity. This ultrasound-induced cold gelation method has the potential to develop new functional protein/sugar gel products with tailor-made attributes.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Chemical
Guilherme de Figueiredo Furtado, Ana Gabriela da Silva Carvalho, Miriam Dupas Hubinger
Summary: This study investigated the influence of protein-protein interactions and different types of oils on the characteristics of infant formula powders. Lactoferrin and medium chain triacylglycerols were found to improve stability and encapsulation efficiency of emulsions and powders.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Xiaoge Zhang, Tiehua Zhang, Siyao Li, Ru Zhao, Shuyi Li, Cuina Wang
Summary: The study explores the potential of using pea protein as a replacement for milk protein in cold-set gels of oil-in-water emulsions. The results show that increasing the concentration of pea protein in the emulsions leads to an increase in particle size and a decrease in surface charge. The redness and yellowness of the emulsion gels are enhanced with higher percentages of pea protein. Pea protein also provides better water retaining ability compared to milk protein, and the hardness and chewiness of the emulsion gels decrease with increasing proportions of pea protein.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Juliana A. S. Leite, Randall C. Robinson, Jaime Salcedo, Juliana N. R. Ract, Virginia S. Quintal, Carmen C. Tadini, Daniela Barile
Summary: This study investigated the impact of microwave-assisted heating on the concentration of key biological compounds in donor human milk. Compared to low-temperature long-time pasteurization, microwave-assisted heating better preserved the concentration of immunoglobulins and lactoferrin, making it a promising alternative method for Human Milk Banks.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Shruti Sharma, Himanshu Prabhakar, Rakesh K. Singh
Summary: This study investigates the effect of atmospheric cold plasma (ACP) processing on major milk proteins. Results show that ACP can partially denature and redistribute whey proteins, enhancing the functional properties of milk and potentially reducing its allergenicity.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Stella Agradi, Marta Gonzalez-Cabrera, Anastasio Argueello, Lorenzo Enrique Hernandez-Castellano, Noemi Castro, Laura Menchetti, Gabriele Brecchia, Daniele Vigo, Edoardo Tuccia, Giulio Curone
Summary: This study aimed to characterize the colostrum quality in different goat breeds and found that there are differences in fat, total solids, lactose, and protein percentages among breeds. It was also found that IgG is the parameter that best differentiates local breeds from cosmopolitan ones. The differences in colostrum quality could be influenced by farming systems and genetic characteristics.
Article
Microbiology
Alessandra Pino, Tommaso Mazza, Maura-Ann H. Matthews, Stefano Castellana, Cinzia Caggia, Cinzia L. Randazzo, Gary A. Gelbfish
Summary: Gardnerella species are key players in the development and recurrence of Bacterial Vaginosis (BV), often showing high resistance to antibiotics. Bovine lactoferrin may be a potential candidate for treating Gardnerella species infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Kenneth Daniel, Luis Vitetta, Maria A. Fiatarone Singh
Summary: Olive-based interventions show promising effects in murine models of UC, with milder disease outcomes favoring the intervention in most studies, suggesting potential clinical relevance. However, further research is needed to determine if these effects would translate to individuals living with UC.
BRITISH JOURNAL OF NUTRITION
(2022)
Letter
Gastroenterology & Hepatology
Jiezhong Chen, Luis Vitetta
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Review
Neurosciences
Jiezhong Chen, Luis Vitetta, Jeremy D. Henson, Sean Hall
Summary: Non-alcoholic fatty liver disease (NAFLD) can progress to severe conditions and is associated with gut dysbiosis. Controlling inflammation is crucial in preventing disease progression. This review focuses on the roles of tryptophan and its metabolites in NASH, in association with gut dysbiosis, and discusses potential therapeutic implications.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2022)
Letter
Oncology
Luis Vitetta, Jason F. Sikali, Courtney Fletcher, Jeremy D. Henson
SUPPORTIVE CARE IN CANCER
(2022)
Editorial Material
Nutrition & Dietetics
Luis Vitetta
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Immunology
Jeremy D. Henson, Luis Vitetta, Sean Hall
Summary: Combination tetrahydrocannabinol (THC)/cannabidiol (CBD) medicines or CBD-only medicines have the potential to be effective treatments for chronic pain, stress, anxiety, depression, and insomnia. There is substantial evidence supporting the effectiveness of THC/CBD combination medicines for chronic pain, especially neuropathic and nociplastic pain. CBD-only medication shows substantial evidence for stress, moderate evidence for anxiety and insomnia, and minimal evidence for depression and pain. THC/CBD combination medicines have good tolerability and safety profiles compared to opioid analgesics, but should be avoided in patients with depression, psychosis, and suicide tendencies.
INFLAMMOPHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Luis Vitetta
Summary: The vermiform cecal appendix was historically considered a vestigial organ with no significant function, believed to have had an important role in early human evolution but becoming less relevant over time.
CURRENT OPINION IN GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Stephen Clarke, Belinda E. Butcher, Andrew J. McLachlan, Jeremy D. Henson, David Rutolo, Sean Hall, Luis Vitetta
Summary: This pilot study assessed the safety, tolerability, pharmacokinetics, and exploratory analgesic effect of a novel water-soluble cannabis-based medicine in patients with advanced incurable malignancy. The results showed acceptable bioavailability and preliminary evidence of analgesic efficacy, but also reported mild to moderate adverse events.
Article
Clinical Neurology
Gabrielle Ritchie, Esben Strodl, Sophie Parham, Matthew Bambling, Susanna Cramb, Luis Vitetta
Summary: This study examines the diversity and composition of the gut microbiome in patients with major depressive disorder (MDD) with and without anxious distress. The results suggest that there are significant differences in the relative abundance of gut microbiota between the two subtypes, although no differences were found in alpha-diversity, richness, evenness or beta diversity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Microbiology
Luis Vitetta, Matthew Bambling, Esben Strodl
Summary: The effect of the intestinal microbiome on the gut-brain axis is important and complex, with evidence showing that intestinal bacteria can influence emotions and behavior. Probiotics, such as Lactobacillus and Bifidobacterium, have potential health benefits including immunomodulation, but their efficacy in improving mood can vary and depends on multiple factors. Understanding the pathways linking probiotics with mood improvements can help identify the factors that contribute to their effectiveness. Adjunctive therapies with probiotics for mood disorders may have the ability to enhance beneficial mood dispositions through molecular mechanisms such as DNA methylation.
Review
Biochemistry & Molecular Biology
Luis Vitetta, Nick N. Gorgani, Gemma Vitetta, Jeremy D. Henson
Summary: Hypoglycemic medications that can be used together with prebiotics and functional foods can reduce the burden of metabolic diseases, particularly Type 2 Diabetes Mellitus. The combination treatment improves the gut microbiome by increasing the diversity of microbial niches and promoting the growth of beneficial bacteria. This leads to higher levels of short-chain fatty acids, which provide energy sources for the gut microbiome and improve intestinal health. The treatment also improves gut barrier integrity and reduces the risk of developing Type 2 Diabetes Mellitus.
Article
Public, Environmental & Occupational Health
Sophie Lewis, Giselle Newton, Katherine Kenny, Frances Boyle
Summary: As public awareness of cancer has increased, there has been a proliferation of normative visions of cancer survivorship that emphasize positivity and perseverance in pursuit of a cure. However, for people with metastatic cancer, these visions can undermine their sense of belonging to the broader community of cancer survivors.
SOCIOLOGY OF HEALTH & ILLNESS
(2023)
Article
Oncology
Luis Vitetta
Summary: Investigations on the human microbiome have changed the focus of medicine on bacteria. A recent research review suggests that commensal intestinal bacteria may have the capacity to modulate the efficacy of cancer immunotherapy through immune checkpoint inhibitors (ICIs). Evidence has shown that the intestinal microbiome can modulate outcomes of ICIs therapies through antigen-specific and antigen-independent mechanisms.
Article
Sociology
Marika Franklin, Karen Willis, Sophie Lewis, Lorraine Smith
Summary: This passage discusses the importance of self-management and presents four propositions for a relational and socially situated reconceptualization of self-management. The goals of self-management are social practices that emerge through patient-professional interactions and are energized by legitimized capital.
JOURNAL OF SOCIOLOGY
(2023)
Letter
Pharmacology & Pharmacy
Luis Vitetta, Tomas Andersen, Michelle Quezada, Dave Rutolo, Jeremy D. Henson
CANNABIS AND CANNABINOID RESEARCH
(2022)