Article
Dentistry, Oral Surgery & Medicine
Elena Bardellini, Francesca Amadori, Federica Veneri, Giorgia Albini, Fulvio Porta, Majorana Alessandra
Summary: This study aims to identify the prevalence of the COMEDY pattern among chemotherapy-induced oral mucositis (OM). A retrospective review of 42 medical records of children undergoing chemotherapy revealed that 14.2% of patients exhibited the COMEDY pattern. These patients not only had oral mucosal lesions, but also experienced dysphagia related to non-erosive reflux disease (NERD) and pediatric neuro-psychiatric (PNP) issues. Recognizing the COMEDY pattern may be crucial for improving treatment effectiveness.
Article
Oncology
Giorgio Attina, Alberto Romano, Palma Maurizi, Sara D'Amuri, Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Antonio Ruggiero
Summary: Oral mucositis is a common complication of chemotherapy for childhood malignancies. The WHO oral mucositis scale is a valuable tool for assessing its severity in pediatric patients. In addition, WBS can be used as an assessment tool to determine the therapy for patients where direct evaluation of the oral cavity is not possible.
FRONTIERS IN ONCOLOGY
(2021)
Review
Microbiology
Silvia Triarico, Pierpaolo Agresti, Emanuele Rinninella, Maria Cristina Mele, Alberto Romano, Giorgio Attina, Palma Maurizi, Stefano Mastrangelo, Antonio Ruggiero
Summary: The oral cavity is the second largest microbiota in the human body, and it plays an important role in the pathogenesis of oral mucositis in children with cancer undergoing chemotherapy. Dysbiosis of the oral microbiota exacerbates inflammation and tissue damage.
Article
Oncology
Dinesh Shah, Aditya Gupta, Jagdish Prasad Meena, Aditya Kumar Gupta, Thirumurthy Velpandian, Ravindra Mohan Pandey, Harshita Makkar, Rachna Seth
Summary: This randomized, double-blind, placebo-controlled trial aimed to evaluate the efficacy and safety of zinc in preventing oral mucositis (OM) in children with cancer receiving intensified chemotherapy. The results showed that oral zinc did not have a significant effect in preventing OM, and no significant adverse events were observed.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Tzu-Rong Peng, Hung-Hong Lin, Li-Jou Yang, Ta-Wei Wu
Summary: This meta-analysis showed that compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy. Oral administration of glutamine and the use of medium or low doses can decrease the risk. Glutamine also had a significant effect in reducing the risk of grade 3 and 4 oral mucositis induced by radiotherapy, especially in prevention.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Chemistry, Medicinal
Saba Safarzadeh, Farinaz Shirban, Mohammad Bagherniya, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Cancer therapy-induced oral mucositis is a troublesome complication after radio-chemotherapy, and factors such as age, nutritional status, tumor type, oral hygiene, treatment method, and oxygen-free radicals can affect its incidence. Herbal medicine has been suggested as a potential alternative due to its unique properties of safety, availability, and low cost, with anti-inflammatory, anti-microbial, and antioxidative activities being essential for its palliative effects on oral mucositis.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yu-Cheng Liu, Chia-Rong Wu, Tsai-Wei Huang
Summary: This meta-analysis demonstrates the effectiveness of probiotics in preventing and mitigating cancer therapy-induced oral mucositis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Matas Jakubauskas, Lina Jakubauskiene, Bettina Leber, Angela Horvath, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The use of chemotherapeutic agents is vital in treating colorectal cancer, but it often leads to intestinal mucositis (IM) with various clinical symptoms. This study aimed to assess the effects of probiotic supplementation on CTx-induced IM in a rat model. The results showed that probiotics alleviated the severity and duration of CTx-induced diarrhea, reduced weight and blood albumin loss, and promoted intestinal cell regeneration.
Article
Chemistry, Multidisciplinary
Liping Deng, Hongliang Zeng, Xueying Hu, Mengqing Xiao, Dong He, Yao Zhang, Yi Jin, Yibo Hu, Yuxing Zhu, Lian Gong, Zhanwang Wang, Liang Xiang, Rongrong Zhu, Yeyu Zhang, Yaxin Cheng, Xingyu Chen, Shuihan Zhang, Yongbo Peng, Ke Cao
Summary: Se@Albumin NPs, developed through self-assembly, significantly improved CDDP-induced intestinal mucositis in mouse models by regulating gut microbiota. Fecal microbiota transplantation from Se@Albumin NP-treated mice also provided significant protection against CDDP-induced intestinal mucositis in pseudo-aseptic mice.
Review
Oncology
Clifton P. Thornton, Mengchi Li, Chakra Budhathoki, Chao Hsing Yeh, Kathy Ruble
Summary: Anti-inflammatory mouthwashes are a potentially effective means to prevent or reduce mucositis associated with cancer therapy, reducing the incidence of symptomatic mucositis and dose-limiting mucositis. Limited adverse effects and high adherence indicate the safety and feasibility of using these mouthwashes. They should be considered for supportive care in individuals at risk for mucositis and further evaluated for efficacy across various chemotherapy agents, adverse effects, and impacts on symptoms, pain, and quality of life.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Dentistry, Oral Surgery & Medicine
Khodayar Oshvandi, Seyed Yaser Vafaei, Seyed Ramesh Kamallan, Salman Khazaei, Hossein Ranjbar, Fateme Mohammadi
Summary: This study demonstrated that zinc chloride mouthwash is effective in preventing and reducing the severity of oral mucositis in cancer patients undergoing chemotherapy, as well as improving weight loss. Further studies are recommended to investigate the preventive effects of zinc chloride at the beginning of chemotherapy for better oral health and weight management in these patients.
Editorial Material
Dentistry, Oral Surgery & Medicine
Elliot Abt
Summary: The study investigated the impact of cancer patients receiving chemotherapy, radiotherapy, or chemo-radiotherapy on oral mucositis and found that the use of probiotics significantly reduced the risk of moderate to severe oral mucositis, as well as overall risk. However, there were no significant results for cancer therapy completion rate and patients receiving chemoradiotherapy.
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2021)
Article
Dentistry, Oral Surgery & Medicine
L. Najaf, N. Borgvall, K. Vennman, J. Walladbegi
Summary: Cryotherapy using ice chips is an effective method to prevent chemotherapy-induced oral mucositis, but it may cause adverse reactions. This study aimed to evaluate the efficacy and tolerability of extraoral cooling for reducing intraoral temperature.
Article
Pharmacology & Pharmacy
S. S. Alqahtani, D. A. A. Siraj Khan
Summary: This systematic review found that good oral care, glutamine, certain biological agents, and laser therapy have a significant impact in reducing the pain sensation and occurrence of oral mucositis in children.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Patricia Maria Fernandes, Pedro Luiz Rosalen, Diego Tetzner Fernandes, Emmanuel Dias-Neto, Severino Matias Alencar, Bruno Bueno-Silva, Fabio de Abreu Alves, Marcio Ajudarte Lopes
Summary: This study demonstrated that oral Brazilian Organic Propolis can alleviate oral mucositis, dysphagia, dysgeusia, and pain induced by radiotherapy, while reducing the occurrence of oral candidiasis. Additionally, propolis can decrease the levels of proinflammatory cytokines in the oral mucosa.
FRONTIERS IN PHARMACOLOGY
(2022)