期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 59, 期 6, 页码 2301-2311出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.5b01157
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Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaacienosine C-nucleoside, have been recently described as effective against filovirus infections (Marburg) and hepatitis C virus (HCV), respectively. The first C-nudeoside analogues were described about half a century ago. The C-nucleoside pseudouridine is a natural component of RNA, and various other C-nucleoside analogues have been reported previously for their antiviral and/or anticancer potential) the most prominent being pyrazofurin, tiazofurin, and selenazofurin. In the meantime, showdomycin, formycin, and various triazole, pyrazine, pyridine, dihydroxyphenyl, thienopyrimidine, pyrazolotriazine, and porphyrin C-nucleoside analogues have been described. It would be worth revisiting these C-nucleosides phosphoramidates, for their therapeutic potential in the treatment of virus infections and derivatives thereof, including their and, where appropriate, cancer as well.
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