期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 58, 期 5, 页码 2088-2090出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.5b00294
关键词
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Chemical probes are important both as tools to understand biology and as starting points for drug leads, but not every active molecule makes a good probe; many react nonspecifically with thiols. These promiscuous inhibitors are worse than useless because they can mislead researchers and muddy the literature. Understanding the mechanisms of such compounds, can prevent scientists from following false hits down blind alleys.
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