期刊
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
卷 36, 期 4, 页码 387-396出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2013.02.001
关键词
Culex flavivirus; Insect-only flavivirus; Culex mosquitoes
资金
- National Science Council, Taiwan [NSC 98-2313-B-005-014-MY3, NSC 99-2321-B-005-008-MY3]
Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell-cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster. (c) 2013 Elsevier Ltd. All rights reserved.
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