期刊
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
卷 35, 期 3, 页码 219-226出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2011.11.003
关键词
Neonatal vaccination; Bacille Calmette Guerin; Natural killer cell; gamma delta T cell; Dendritic cell
资金
- Biotechnology and Biological Sciences Research Council, UK
Bovine tuberculosis is a disease of increasing incidence in the UK causing major economic losses and with significant impact on bovine and, potentially human health: the causative agent Mycobacterium bovis is a zoonotic pathogen. Neonatal vaccination with the attenuated M. bovis Bacille Calmette Guerin (BCG) vaccine confers a significant degree of protection in cattle, and is a widely used control strategy for human TB. The adaptive immune system is relatively immature in neonates and increased numbers of innate effector cells present in young animals and human infants may compensate for this, enabling effective immune responses to vaccination. Natural killer cells and subsets of gamma delta TCR+ T lymphocytes secrete high levels of interferon gamma and can interact with antigen presenting cells to promote both innate and adaptive immune responses. These cell populations may be pivotal in determining immune bias following neonatal vaccination with BCG. (C) 2011 Elsevier Ltd. All rights reserved.
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