Article
Pharmacology & Pharmacy
Shihao Huang, Yu Zhou, Feilong Wu, Cuijie Shi, He Yan, Liangpei Chen, Chang Yang, Yixiao Luo
Summary: This study found that berberine combined with extinction training can effectively promote the extinction of fear memories and prevent their reinstatement and spontaneous recovery. This finding provides a new potential avenue for the treatment of fear-related disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Yu Chen, Xiao Lin, Sizhi Ai, Yan Sun, Le Shi, Shiqiu Meng, Lin Lu, Jie Shi
Summary: The study suggests that novelty-facilitated extinction has a superior effect in preventing fear generalization, providing new perspectives for enhancing the effect of exposure therapy.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Kairo Alan Albernaz-Mariano, Carolina Demarchi Munhoz
Summary: Individuals return to normal lifestyle after adversity, but memory distortions and impairment can occur in stress-related disorders. Glucocorticoids target mineralocorticoid and glucocorticoid receptors to coordinate stress responses. The relationship between stress, infralimbic mPFC, and memory, as well as MR-mediated intracellular signaling, play a crucial role in memory extinction.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Hotaka Fukushima, Yue Zhang, Satoshi Kida
Summary: The study revealed that an ERK-dependent memory transition process after retrieval regulates the switch of memory phases from reconsolidation to extinction by preventing the induction of reconsolidation. This process involves distinct molecular and cellular signatures in brain regions related to fear memory, offering insights into the mechanism of memory transition.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Fernando Midea Cuccovia Reis, Leonardo Santana Novaes, Nilton Barreto dos Santos, Kelvia Carolina Ferreira-Rosa, Juliano Genaro Perfetto, Marcus Vinicius C. Baldo, Carolina Demarchi Munhoz, Newton Sabino Canteras
Summary: Previous studies have found that the basolateral amygdala (BLA) and the ventral hippocampus (VH) play critical roles in predator-related fear memory storage. Protein synthesis and glucocorticoid hormones are involved in modulating this process. Exposure to a predatory threat leads to rapid glucocorticoid release and facilitates fear memory consolidation.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marcin Piechota, Urszula Skupio, Malgorzata Borczyk, Barbara Ziolkowska, Slawomir Golda, Lukasz Szumiec, Klaudia Szklarczyk-Smolana, Wiktor Bilecki, Jan Manuel Rodriguez Parkitna, Michal Korostynski
Summary: The expression of Ca2+/Calmodulin-Dependent Protein Kinase I gamma (Camk1g) is regulated by stress and glucocorticoid receptors (GR) in neuronal cells of the limbic system. It is involved in anxiety-related behaviors and responses conditioned by aversive stimuli.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Daniel Jercog, Nanci Winke, Kibong Sung, Mario Martin Fernandez, Claire Francioni, Domitille Rajot, Julien Courtin, Fabrice Chaudun, Pablo E. Jercog, Stephane Valerio, Cyril Herry
Summary: The study found that threat representations and avoidance behavior initiation are dynamically encoded in the overall population activity of dmPFC neurons in mice. While dmPFC population activity at stimulus onset encodes sustained threat representations driven by the amygdala, it does not predict action outcome. Transient dmPFC population activity before the initiation of action reliably predicts avoided from non-avoided trials, revealing the dynamic process of information linking threats with defensive actions within prefrontal networks.
Article
Neurosciences
Xiaoyu Cui, Songhua Zhou, Guang Xia, Jie Chen, Lizhu Jiang, Jufang Huang, Jianbin Tong
Summary: The study suggests that probiotics treatment after fear conditioning can promote long-term fear extinction, inhibit fear memory recovery, possibly through alleviating synaptic pruning of activated microglial cells. Probiotics may be applicable as a therapeutic strategy to inhibit microglial activation and treat fear-related disorders.
Article
Multidisciplinary Sciences
Bridget L. Kajs, Adrienne C. Loewke, Jeffrey M. Dorsch, Leah T. Vinson, Lisa A. Gunaydin
Summary: This study utilized fiber photometry to record the activity of the dorsomedial prefrontal cortex (dmPFC) and its projections to the dorsomedial striatum (DMS) and basolateral amygdala (BLA) during active avoidance learning in mice. The results showed that both prefrontal projections exhibited learning-related increases in activity, while the overall dmPFC activity showed different patterns during avoidance and cued freezing. The findings highlight the importance of dmPFC projections in active avoidance learning.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Chen-Cheng Lin, Pao-Yun Cheng, Michael Hsiao, Yia-Ping Liu
Summary: The study suggests that early intervention with a GR antagonist can improve fear and anxiety dysregulation caused by traumatic stress and correct related neurochemical abnormalities. This is of great significance for the treatment of psychological disorders following trauma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jacqueline Alves Leite, Ana Maria Orellana, Diana Zukas Andreotti, Amanda Midori Matumoto, Natacha Medeiros de Souza Ports, Larissa de Sa Lima, Elisa Mitiko Kawamoto, Carolina Demarchi Munhoz, Cristoforo Scavone
Summary: This study investigates the effects of endogenous substance ouabain (OUA) on the rat's central nervous system under chronic stress. The results suggest that intermittent administration of OUA can alleviate HPA axis abnormal activity caused by chronic stress, by reducing glucocorticoids levels, CRH-CRHR1 expression, and neuroinflammation via decreasing iNOS activity, without interfering with antioxidant enzymes expression. These changes may lead to the rapid extinction of aversive memory in the hypothalamus and hippocampus.
Article
Neurosciences
C. M. B. Kwee, F. E. van der Flier, P. Duits, A. J. L. M. van Balkom, D. C. Cath, J. M. P. Baas
Summary: This study investigated the effects of cannabidiol (CBD) on fear memory expression and fear re-extinction. The results showed that CBD reduced the expectation of threat during fear retention, but had no effect on fear re-extinction. However, in patients using antidepressant medication, CBD may interfere with the re-extinction of subjective fear.
PSYCHOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Yan Yan, Ailikemu Aierken, Chunjian Wang, Wei Jin, Zhenzhen Quan, Zhe Wang, Hong Qing, Junjun Ni, Juan Zhao
Summary: This review discusses the use of optogenetics and in vivo imaging techniques to study the neural circuits underlying the extinction and discrimination of fear memory. It also highlights the challenge of translating these findings into effective therapeutic treatments for PTSD.
Review
Behavioral Sciences
Ho Namkung, Kerrie L. Thomas, Jeremy Hall, Akira Sawa
Summary: Studies on fear learning and extinction have greatly advanced our understanding of the neurobiology involved. Animal studies offer causal insights for human brain regions and their functional connectivity, while human studies provide macroscopic insights into animal neural circuits. However, there is room for improvement in translating basic and clinical research on fear learning and extinction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biology
Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Tung-Yen Lee, Fang-Chia Chang
Summary: A seven-day model with multiple prolonged stress (MPS) was used to simulate long-term impaired fear extinction in PTSD patients in rodent models. The MPS manipulation induced behavioral and neural changes in rats for 6 weeks, including extended fear memory, increased corticosterone concentrations, enhanced theta oscillation activity, and disrupted sleep-wake activities. This study demonstrated integrated chronic PTSD symptoms in the MPS-induced rodent model.
COMMUNICATIONS BIOLOGY
(2023)
Article
Physiology
Goan E. Nilsson, Jarle Vaage, Kare-Olav Stenslokken
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Michael P. Wilkie, Jonathan A. W. Stecyk, Christine S. Couturier, Sanya Sidhu, Guro K. Sandvik, Goran E. Nilsson
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2015)
Article
Biology
Sjannie Lefevre, Sue-Ann Watson, Philip L. Munday, Goran E. Nilsson
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Article
Biology
Matthew D. Regan, Andy J. Turko, Joseph Heras, Mads Kuhlmann Andersen, Sjannie Lefevre, Tobias Wang, Mark Bayley, Colin J. Brauner, Do Thi Thanh Huong, Nguyen Thanh Phuong, Goran E. Nilsson
JOURNAL OF EXPERIMENTAL BIOLOGY
(2016)
Article
Biology
Wen-Sung Chung, N. Justin Marshall, Sue-Ann Watson, Philip L. Munday, Goran E. Nilsson
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Letter
Biology
Philip L. Munday, Sue-Ann Watson, Wen-Sung Chung, N. Justin Marshall, Goran E. Nilsson
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Biology
Sjannie Lefevre, Christian Damsgaard, Desirae R. Pascale, Goran E. Nilsson, Jonathan A. W. Stecyk
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Kare-Olav Stenslokken, Stian Ellefsen, Olga Vasieva, Yongxiang Fang, Anthony P. Farrell, Lisa Olohan, Jarle Vaage, Goeran E. Nilsson, Andrew R. Cossins
Article
Multidisciplinary Sciences
Katja Anttila, Christine S. Couturier, Oyvind Overli, Arild Johnsen, Gunnhild Marthinsen, Goran E. Nilsson, Anthony P. Farrell
NATURE COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Christine S. Couturier, Jonathan A. W. Stecyk, Stian Ellefsen, Guro K. Sandvik, Sarah L. Milton, Howard M. Prentice, Goran E. Nilsson
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2019)
Article
Biochemistry & Molecular Biology
Arne O. Melleby, Guro K. Sandvik, Christine S. Couturier, Goran E. Nilsson, Jonathan A. W. Stecyk
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Adam T. Downie, Sjannie Lefevre, Bjorn Illing, Jessica Harris, Michael D. Jarrold, Mark I. McCormick, Goeran E. Nilsson, Jodie L. Rummer
Summary: Connectivity of coral reef fish populations relies on successful dispersal of pelagic larvae, which transition rapidly between extremes of physiology at the end of their larval phase. The transition is accompanied by changes in gene expression of oxygen-binding proteins, potentially enhancing hypoxia tolerance and enabling successful recruitment to reefs.
Article
Multidisciplinary Sciences
Anette Johansen, Bernd Thiede, Jan Haug Anonsen, Goran E. Nilsson
Summary: The crucian carp is an excellent model for studying molecular adaptations to anoxia. Mass spectrometry-based proteome analyses revealed major changes in cardiac and hepatic protein levels in response to anoxia and reoxygenation, highlighting the tissue-specific responses to anoxia.
Meeting Abstract
Biochemistry & Molecular Biology
K. Andersson, M. Hammerstad, A. B. Tomter, H. Hersleth, A. K. Rohr, G. Zoppellaro, N. H. Andersen, G. K. Sandvik, G. E. Nilsson, A. Anne-Laure Barra, M. Hogbom, A. Graslund
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Diana Medina-Felix, Francisco Vargas-Albores, Estefania Garibay-Valdez, Luis Rafael Martinez-Cordova, Marcel Martinez-Porchas
Summary: In this research, the effects of Nocardia infection on fish gastrointestinal microbiota were analyzed. It was found that the infection led to decreased survival rate, severe damage to the stomach microbiota, and a significant increase in Proteobacteria. A negative correlation network between Proteobacteria and other important phyla was observed. Therefore, Nocardia sp. is an emerging pathogen capable of inducing dysbiosis and causing significant mortalities.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2024)
Article
Biochemistry & Molecular Biology
Lele Wu, Wen Sun, Jiale Zhou, Yaolin Li, Jun Li, Zongcheng Song, Changbin Song, Shihong Xu, Xinlu Yue, Xian Li
Summary: The study finds that red light induces dichromatic skin pigmentation in turbot juveniles, with some individuals displaying black coloration and others displaying lighter skin. The upregulated gene expressions related to melanin synthesis and the involvement of the nervous system in spectral environment-driven color regulation are both crucial factors.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2024)