Review
Plant Sciences
Yingqi Cai, Xiao-Hong Yu, John Shanklin
Summary: Plants convert carbohydrates into energy-dense lipids through photosynthesis, making plant oils an economically and sustainably attractive feedstock for biofuels and value-added bioproducts. Various strategies have been developed to enhance lipid accumulation and produce specialty lipids with increased uses and value. Successful metabolic engineering involves expression of lipogenic factors from other sources or with specialized functionality.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Xiufen Zhang, Qilin Wu, Wenxuan Zheng, Chuang Liu, Liang Huang, Xin Zuo, Wenquan Xiao, Xiaofeng Han, Hui Ye, Wence Wang, Lin Yang, Yongwen Zhu
Summary: This study investigated the effects of exogenous fatty acid intervention on embryonic development in an avian embryo model. It was found that hepatic lipid and fatty acid metabolism play critical roles in embryogenesis. The intervention with oleic acid affected lipid metabolism and gene expression related to fatty acid uptake, synthesis, and oxidation in the embryos.
Review
Plant Sciences
Lucas Busta, Kent D. Chapman, Edgar B. Cahoon
Summary: This article reviews recent evidence that protein-protein interactions in each of the three major phases of oil formation have profound effects on the accumulation of specialized oils. The authors suggest that further understanding of the noncatalytic attributes of enzymes and other proteins involved in oil formation is critical for creating high performing, engineered oilseeds derived from renewable bioproducts.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julia Moura-Silva, Matheus P. S. Tavares, Fernanda Almeida-Oliveira, David Majerowicz
Summary: Insects are valuable models for studying human metabolic diseases due to their low cost and available tools. This study examines the effect of a high-calorie, high-fat diet supplemented with powdered egg yolk on the metabolism of Tribolium castaneum beetles. The diet increased the beetle's triacylglycerol levels but did not affect glucose levels or lipogenic capacity. It also had no impact on the expression profile of key metabolism genes or insulin-like peptides. Overall, the diet induced increased fat without causing diabetes phenotypes.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Atrayee Chattopadhyay, Mohor Mitra, Mrinal K. Maiti
Summary: Research is currently focusing on several nonconventional oleaginous yeast species for developing renewable and sustainable biolipid feedstock. Significant progress has been made in recent years in understanding metabolic pathways, implementing engineering strategies, and improving genetic tools for various yeast genera, which will benefit future studies in strain improvement and metabolic engineering for enhanced lipid production.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Biochemistry & Molecular Biology
Sami Kazaz, Romane Miray, Loic Lepiniec, Sebastien Baud
Summary: Monounsaturated fatty acids are important components synthesized by plants, with unique structures and biological functions, widely used in the food and chemical industries. Ongoing research into the links between fatty acid structures and functions provides a theoretical basis for the development of new crops rich in monounsaturated fatty acids.
PROGRESS IN LIPID RESEARCH
(2022)
Review
Food Science & Technology
Yee-Ying Lee, Teck-Kim Tang, Eng-Seng Chan, Eng-Tong Phuah, Oi-Ming Lai, Chin-Ping Tan, Yong Wang, Nur Azwani Ab Karim, Noorlida Habi Mat Dian, Joo Shun Tan
Summary: Structured lipids are a modified form of lipid aimed at improving the nutritional and functional properties of conventional fats and oils. Examples of this new generation of healthful lipids, such as MCT and MLCT, are mainly composed of MCFA and have shown multiple physiological and functional properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell Biology
Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia, Shiqi Liu, Tao Wu, Xianli He, Nan Wang
Summary: SLC25A1 is significantly upregulated in CRC, associated with poor survival in patients, and reprograms energy metabolism through two mechanisms to promote CRC growth. It serves as a potential diagnostic marker and therapeutic target in CRC.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Haruhiko Jimbo, Hajime Wada
Summary: This study investigates the role of a lipase in the repair process of Photosystem II (PSII) in Synechocystis sp. PCC 6803. The lipase is found to degrade lipids and enhance the degradation of damaged proteins, thereby facilitating the repair of PSII.
Review
Plant Sciences
Linhui Yu, Chao Zhou, Jilian Fan, John Shanklin, Changcheng Xu
Summary: Lipid remodeling, defined as post-synthetic modifications of membrane lipids, plays a crucial role in regulating cellular membrane properties and functions. Processes affected by lipid remodeling include lipid metabolism, membrane repair, cellular homeostasis, fatty acid trafficking, cellular signaling, and stress tolerance. Recent research focuses on understanding the mechanisms of membrane lipid remodeling, particularly the enzymes involved in modifying major membrane lipids such as phosphatidylcholine and monogalactosyldiacylglycerol.
Review
Oncology
Jan Korbecki, Mateusz Bosiacki, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This review discusses the synthesis and significance of fatty acids, glycerophospholipids, and triacylglycerol in glioblastoma. The focus is on all enzymes involved in the synthesis of these lipids, highlighting their roles in the tumorigenesis of glioblastoma. Due to the fact that the role of many of these enzymes in glioblastoma tumorigenesis remains unexplored, we conducted a bioinformatic analysis based on the GEPIA database to indicate their possible functions and significance.
Review
Plant Sciences
Shengnan Zhu, Cuiyue Liang, Jiang Tian, Yingbin Xue
Summary: This review summarizes recent discoveries and molecular basis of plant adaptive mechanisms to low phosphate availability, providing insights into the molecular mechanisms underlying plant adaptation to phosphorus starvation and facilitating the development of crop cultivars with high phosphorus utilization efficiency.
Review
Oncology
Xingkai Liu, Ping Zhang, Jing Xu, Guoyue Lv, Yan Li
Summary: Bioactive lipid molecules play important roles in linking obesity/metabolic syndrome and cancers. Controlling lipid metabolism can be a potential strategy for cancer prevention and therapy. Comprehensive understanding of the regulatory role of lipid metabolism in cellular entities and their tumor microenvironment will provide a new direction for further studies and development of novel anti-cancer strategies.
CANCER CELL INTERNATIONAL
(2022)
Article
Environmental Sciences
Yuxing Wang, Xin Hua, Dayong Wang
Summary: Exposure to 6-PPDQ leads to lipid accumulation and inhibition of fatty acid β-oxidation in Caenorhabditis elegans. This lipid accumulation is associated with increased fatty acid synthesis and increased synthesis of monounsaturated fatty acylCoAs. Additionally, metabolic sensors sbp-1 and mdt-15 are upregulated in response to 6-PPDQ exposure.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Christoph Heier, Svitlana Klishch, Olha Stilbytska, Uliana Semaniuk, Oleh Lushchak
Summary: The deposition of storage fat in the form of triacylglycerol (TAG) is a conserved strategy to cope with energy availability and metabolic stress. The fruit fly Drosophila melanogaster has been established as a model system to study TAG metabolism and the etiology of lipid-associated metabolic diseases, showing potential in understanding the genetic and dietary basis of TAG storage and related disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Genetics & Heredity
C. Fernando Garcia, Nicolas Pedrini, Arturo Sanchez-Paz, Carlos S. Reyna-Blanco, Sabrina Lavarias, Adriana Muhlia-Almazan, Analia Fernandez-Gimenez, Aldana Laino, Enrique de-la-Re-Vega, German Lukaszewicz, Alonso A. Lopez-Zavala, Luis G. Brieba, Michael F. Criscitello, Jesus S. Carrasco-Miranda, Karina D. Garcia-Orozco, Adrian Ochoa-Leyva, Enrique Rudino-Piner, Alejandro Sanchez-Flores, Rogerio R. Sotelo-Mundo
Article
Zoology
Carolina Tropea, Sabrina Maria Luisa Lavarias, Laura Susana Lopez Greco
Article
Biochemical Research Methods
Jack C. H. Ip, Huawei Mu, Yanjie Zhang, Jin Sun, Horacio Heras, Ka Hou Chu, Jian-Wen Qiu
JOURNAL OF PROTEOMICS
(2019)
Article
Biochemistry & Molecular Biology
Jin Sun, Huawei Mu, Jack C. H. Ip, Runsheng Li, Ting Xu, Alice Accorsi, Alejandro Sanchez Alvarado, Eric Ross, Yi Lan, Yanan Sun, Alfredo Castro-Vazquez, Israel A. Vega, Horacio Heras, Santiago Ituarte, Bert Van Bocxlaer, Kenneth A. Hayes, Robert H. Cowie, Zhongying Zhao, Yu Zhang, Pei-Yuan Qian, Jian-Wen Qiu
MOLECULAR BIOLOGY AND EVOLUTION
(2019)
Article
Multidisciplinary Sciences
Ignacio Rafael Chiumiento, Santiago Ituarte, Jin Sun, Jian Wen Qiu, Horacio Heras, Marcos Sebastian Dreon
Article
Biodiversity Conservation
M. Y. Pasquevich, H. Heras
BIOLOGICAL INVASIONS
(2020)
Article
Biochemistry & Molecular Biology
Rosana Crespo, Boris E. Rodenak-Kladniew, Maria A. Castro, Maria Soberon, Sabrina M. L. Lavarias
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Immunology
Matias L. Giglio, Santiago Ituarte, Andres E. Ibanez, Marcos S. Dreon, Eduardo Prieto, Patricia E. Fernandez, Horacio Heras
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Environmental Sciences
M. R. Fernandez San Juan, A. Cortelezzi, C. B. Albornoz, S. M. Landro, F. Arrighetti, R. Najle, S. M. L. Lavarias
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Biology
Tabata R. Brola, Marcos S. Dreon, Jian-Wen Qiu, Horacio Heras
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
M. L. Giglio, S. Ituarte, V Milesi, M. S. Dreon, T. R. Brola, J. Caramelo, J. C. H. Ip, S. Mate, J. W. Qiu, L. H. Otero, H. Heras
JOURNAL OF STRUCTURAL BIOLOGY
(2020)
Article
Zoology
Maria Cecilia Chiale, Maria Pilar Cadierno, Patricia Fernandez, Sergio Mijailovsky, Horacio Heras, Claudio Barbeito, Diego Montalti
Summary: Flamingos have specialized uropygial gland characteristics, with Chilean Flamingos displaying unique features possibly related to their adaptation to aquatic environments. The preen secretion of this species contains glycoconjugates with potential antimicrobial properties, while the absence of diester waxes in flamingos may be linked to their nesting habits and limited exposure to predation.
Article
Marine & Freshwater Biology
Florencia Arrighetti, Sonia M. Landro, Sabrina M. L. Lavarias
Summary: The aim of this study was to evaluate the toxic effects of the pesticide cypermethrin on the digestive gland of the apple snail. The study found that cypermethrin exposure caused tissue damage in the digestive gland, including disorganisation of the connective tissue and various pathological conditions. Some histological and histochemical parameters were found to be sensitive indicators of cypermethrin exposure in the snail species.
AQUATIC TOXICOLOGY
(2022)
Article
Marine & Freshwater Biology
S. M. L. Lavarias, G. B. Peterson, L. C. Lagrutta, C. Tropea, J. E. Colman Lerner, A. Rodrigues Capitulo, A. Ves-Losada
Summary: Pollutants and starvation can disrupt the lipid homeostasis in aquatic organisms. This study investigated the combined effects of starvation and toxicant exposure on neutral lipids in the freshwater snail Pomacea canaliculata. Starved snails were exposed to sublethal concentration of cypermethrin for 4 and 10 days. The results showed a decrease in neutral lipid content under starvation, but an increase in triacylglycerol content after pesticide exposure. The fatty acid composition of triacylglycerols was significantly altered in stressed snails. These findings suggest that lipid homeostasis alteration may be an adaptive mechanism to lipophilic and obesogenic pollutants in aquatic organisms.
AQUATIC TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matias L. Giglio, Wilhelm Boland, Horacio Heras
Summary: This article provides an overview of animal egg toxins, analyzing their chemistry and biosynthesis trends and patterns. It identifies around 100 properly identified egg toxins in 188 species, distributed across 5 phyla. The article proposes a multiparametric classification system and emphasizes the origin, structure, function, and toxicity range of egg toxins, as well as the existence of aposematic coloration in toxic eggs. However, there is still a significant lack of information in this field.
NATURAL PRODUCT REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Fuqiang Ge, Qiaoling Yu, Jun Zhang, Yaoyao Han, Dongfa Zhu, Xi Xie
Summary: The E93 gene was identified and found to be widely distributed in adult tissues of the swimming crab. The expression levels of PtE93 mRNA in Y-organ and epidermis fluctuated during the molt cycle, suggesting its involvement in juvenile molting. Treatment with 20E induced PtE93 expression, while treatment with MF showed the opposite effect. The study also observed a negative correlation between PtE93 and ecdysteroid biosynthesis genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Manuel Marrero, Oscar Monroig, Jose A. Perez, Monica B. Betancor, Ana Galindo, Ana Bolanos, N. Guadalupe Acosta, Covadonga Rodriguez
Summary: This study investigated the combined effects of partial dietary replacement of fish oil (FO) by vegetable oil (VO) and reduced ambient salinity on the fatty acid composition of C. labrosus juveniles. The results showed that C. labrosus is able to biosynthesise EPA and DHA from ALA, and low salinity conditions can upregulate the gene expression related to fatty acid metabolism. Fish reared on FO20 diet showed the highest amount of n-3 LC-PUFA in muscle.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Davide Degli Esposti, Aureline Lalouette, Karen Gaget, Louveline Lepeule, Zineb Chaabi, Maxime Lepretre, Anabelle Espeyte, Nicolas Delorme, Herve Queau, Laura Garnero, Federica Calevro, Arnaud Chaumot, Olivier Geffard
Summary: Metal pollution has significant effects on aquatic environments, and metallothioneins play important roles in maintaining metal homeostasis and detoxification. This study identified two metallothionein-coding transcripts in Gammarus fossarum and investigated their organ-specific expression patterns. The results showed that mt1 was more strongly induced after cadmium exposure, and mt1 was more highly induced in the caeca compared to the gills for any metal exposure. Additionally, mt2 was more inducible in the gills than in the caeca for cadmium and zinc exposure at the individual level.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cuihong You, Shuangshuang Miao, Zhiyong Xie, Siyuan Lin, Shuqi Wang, Cuiying Chen, Li Lin, Yanhua Huang, Meng Zhou, Yewei Dong, Yuanyou Li, Ping Zhuang
Summary: The rabbitfish S. guttatus was found to have the capability for LC-PUFA biosynthesis, with the expression of related genes varying temporally and spatially during embryogenesis and being influenced by ambient salinity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Saydur Rahman, Mohammad Maruf Billah, Victor Rangel, Esmirna Cantu
Summary: Global warming has severe impacts on the reproductive fitness of marine invertebrates. In this study, the researchers used various techniques to investigate the effects of high temperatures on global DNA methylation, cellular apoptosis, and nitrative stress in the gonads of Atlantic sea urchins.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
E. S. Kladchenko, A. A. Tkachuk, M. S. Podolskaya, A. Yu. Andreyeva
Summary: This study investigated the osmotic stability and cellular responses of hemocytes in Mediterranean mussel and Pacific oyster. The results revealed that both species showed cellular volume changes and alterations in mitochondrial membrane potential upon hypoosmotic swelling. These findings provide insights into the cellular responses of bivalve mollusks to osmotic stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yuya Ohhara, Chiemi Sagisaka, Kimiko Yamakawa-Kobayashi
Summary: This study investigated the biosynthetic capacity of n-3 PUFAs in the terrestrial invertebrate Sinella dubiosa, and found that it can metabolize oleic, linolenic, and arachidonic acids to produce EPA, suggesting that it may serve as an EPA source in soil ecosystems.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
N. Perales-Garcia, D. Tovar-Ramirez, M. G. Martinez-Morales, B. P. Ceballos-Vazquez, D. A. Corona-Rojas, M. A. Salcedo-Meza, A. Garrido-Mora, F. Vega-Villasante, H. Nolasco-Soria
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
N. Perales-Garcia, D. Tovar-Ramirez, M. G. Martinez-Morales, B. P. Ceballos-Vazquez, D. A. Corona-Rojas, M. A. Salcedo-Meza, A. Garrido-Mora, F. Vega-Villasante, H. Nolasco-Soria
Summary: This study provides the first report on the digestive tract pH of the pygmy octopus. The pH of the digestive tract regions was found to be lower than 7.0 and did not differ significantly between wild and captive octopuses. The digestive gland had the lowest pH values, but they were still above 5.0.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Carlos Espirito-Santo, Carmen Alburquerque, Francisco A. Guardiola, Rodrigo O. A. Ozorio, Leonardo J. Magnoni
Summary: Swimming has physiological effects on farmed fish, but the potential link between swimming and oxidative stress is still poorly understood. This study investigated the impact of different moderate swimming conditions on the antioxidant status of gilthead seabream, revealing that swimming modulated the activity of antioxidant enzymes in the liver and skeletal muscle. Adequate swimming conditions were found to minimize oxidative stress in gilthead seabream.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingxin Zhang, Chaobin Qin, Junli Wang, Liping Yang, Xiao Yan, Shaoyang Zhi, Guoxing Nie
Summary: The study focuses on the expression patterns of PFK genes in response to glucose, insulin, and glucagon stimuli in grass carp. The findings suggest that PFK family genes have different or even opposite expression patterns in various tissues, which may contribute to glucose intolerance in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jianshuang Li, Likang Lyu, Haishen Wen, Yun Li, Xiaojie Wang, Yijia Yao, Xin Qi
Summary: This study investigated the transcriptional regulation of estrogen receptors (ESRs) on isotocin receptors (itrs) in guppies, and found that estrogen can regulate oxytocin receptor expression in ovoviviparous teleosts. The study also demonstrated that ESR1 represses itr2 promoter activity in an estrogen-dependent manner, while overexpression of ESR2a or ESR2b enhances itr2 promoter activity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Wan-Xin Li, Li-Ting Cai, Yan-Ping Huang, Yuan-Qing Huang, Shu-Hui Pan, Zhi-Long Liu, Charles Brighton Ndandala, Gang Shi, Si-Ping Deng, Hong-Juan Shi, Guang-Li Li, Dong-Neng Jiang
Summary: In this study, it was found that S. argus has two lep genes, with lepa highly expressed in the liver and lepb not detected in any tissue. lepa was found to play a role in regulating female reproduction in S. argus.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Xiang Wu, Xiao-Ying Tan, Yi-Chuang Xu, Hua Zheng, Xiao-Lei Wei, Wu-Hong Lv, Zhi Luo
Summary: This study investigates the mechanisms underlying the activation of lipophagy in yellow catfish under high glucose-induced lipid deposition. The SIRT1-NRF2-TFEB pathway is proposed to mediate lipophagy activation, and lipophagy helps alleviate high glucose-induced lipid deposition. This study provides insights into the control of lipophagy in response to metabolic stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)