Article
Environmental Sciences
Reyhaneh Ravanbakhsh, Naser Agh, Mojtaba Nouraein, Peter Bossier
Summary: The ecological crisis in recent years has led to changes in the adaptation mechanisms of Artemia urmiana in Urmia Lake, with increased Hsp-70 expression levels and improved response to environmental stressors in nauplii exposed to long-term ecological crisis.
ENVIRONMENTAL RESEARCH
(2023)
Article
Behavioral Sciences
Juliano Viana Borges, Vivian Naziaseno Pires, Betania Souza de Freitas, Gabriel Ruebensam, Vitoria Correa Vieira, Cristophod de Souza dos Santos, Nadja Schroder, Elke Bromberg
Summary: Social deprivation can cause stress in group-living mammals, but they have an amazing response of seeking social contact as a form of protection. This study explored the effects of social isolation and support on behavioral and epigenetic responses to chronic stress in middle-aged adult rats. The results showed that isolation led to decreased corticosterone levels, impaired long-term memory, and decreased BDNF gene expression, along with altered epigenetic markers. The chronic unpredictable stress protocol had different effects, mainly on epigenetic alterations, but social support prevented the adverse effects on HPA axis functioning and gene expressions.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
L. B. Yu, C. Guan, Y. H. Dong, F. Q. Meng, W. W. Song, B. J. Ji
Summary: The study found that SDG can significantly reduce blood glucose, urine albumin, and creatinine levels in diabetic nephropathy model mice, as well as decrease the expression of inflammatory factors. Additionally, SDG slows down TLR4-mediated inflammation by regulating HSP-70 levels to achieve kidney protection.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Medicine, Research & Experimental
Jiao Ge, Yan Liu
Summary: This study investigated the serum expression of HSP-70 in children with ITP and healthy controls, and found that the expression of HSP-70 is associated with the progression and severity of childhood ITP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shoko Takemura, Ayami Isonishi, Noriko Horii-Hayashi, Tatsuhide Tanaka, Kouko Tatsumi, Takashi Komori, Kazuhiko Yamamuro, Mariko Yamano, Mayumi Nishi, Manabu Makinodan, Akio Wanaka
Summary: Accumulating evidence has shown that social stress during the juvenile period affects the activity of the hypothalamic-pituitary-adrenal (HPA) axis in adulthood. In this study, adult mice that experienced social isolation during postnatal day 21-35 (juvenile social isolation (JSI) group) were compared to normally reared mice (control group) to investigate the mechanisms underlying this phenomenon. The JSI group mice showed a weakened HPA response to acute swim stress, and there were morphological changes in the tanycytic endfeet in the median eminence, potentially related to the HPA response.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Immunology
Xuesong Zhang, Yuansheng Duan, Jinru Ma, Zhibing Liu, Yani Ding, Haibo Xie, Jiale Peng, Feng Wang, Jiaxiang Zhang, Qixing Zhu
Summary: Trichloroethylene (TCE), a widely used volatile chlorinated solvent, can cause adverse effects on human and animal health. This study investigates the role of Sirtuin-1 (SIRT 1) in TCE-induced immune renal tubular injury. The results suggest that SIRT 1 alleviates renal tubular epithelial cells immune injury by inhibiting the release of HSP 70 and weakening its interaction with TLR 4.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Moustafa Algamal, Andrew J. Pearson, Coral Hahn-Townsend, Ioana Burca, Michael Mullan, Fiona Crawford, Joseph O. Ojo
Summary: This study assessed the impact of chronic stress on HPA axis function and fear memory deficits in a mouse model, finding that mice exposed to chronic stress exhibited exaggerated fear memory recall and weakened HPA axis functionality. Neuroendocrinal testing suggested that alterations in adrenal MC2 receptor reactivity may be related to the attenuated stress response in the model.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Veterinary Sciences
Berlin Pandapotan Pardede, Asmarani Kusumawati, Mulyoto Pangestu, Bambang Purwantara
Summary: The study aimed to analyze the potential of HSP-70 molecules in bovine sperm as a marker for cryo-tolerance or freezability, and its association with semen quality and fertility rate. Results showed that the abundance of HSP-70 molecules at the gene and protein level was higher in bulls with good freezability (GF) compared to those with poor freezability (PF). The frozen-thawed sperm quality parameters were significantly higher in GF bulls, and HSP-70 molecules were positively correlated with fertility rate and negatively associated with low mitochondrial membrane potential and sperm DNA damage.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Haifa Othman, Alberto Lopez-Furelos, Jose Manuel Leiro-Vidal, Mohamed Ammari, Mohsen Sakly, Hafedh Abdelmelek, Aaron angel Salas-Sanchez, Francisco Ares-Pena, Elena Lopez-Martin
Summary: The study found that repeated exposure to 2.45 GHz radiation led to dysregulation of GCR and HSP-70 in certain brain regions, while values for these biomarkers were significantly higher in other areas. However, GFAP levels in brain tissue showed no significant differences after irradiation compared to nonirradiated animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Somya Ranjan Dash, Subhajit Chatterjee, Saptarshi Sinha, Biswajit Das, Subarno Paul, Rajalaxmi Pradhan, Chinmayee Sethy, Rupayana Panda, Jasaswini Tripathy, Chanakya Nath Kundu
Summary: A study found that quinacrine-gold hybrid nanoparticles (QAuNP) combined with near-infrared irradiation can disrupt mitochondrial membrane potential, leading to DNA damage and apoptosis in oral squamous cell carcinoma (OSCC) cancer stem cells (CSCs). Additionally, this treatment can regulate the expression of key proteins, enhancing the apoptosis of CSCs. These findings have important implications for tumor therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kalpana Baghel, Rashmi Srivastava
Summary: This study demonstrates that during photorefractoriness, testicular apoptosis occurs in Japanese quail causing reproductive stress. Withania somnifera root extract helps overcome stress and improve reproductive performance by increasing expression of ir-ER alpha. Furthermore, the stress ameliorating effect of WSRE in reducing apoptosis mediated by ir-Caspase-3 and ir-p53 in the testes is evident in Japanese quail.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
Joshua M. Lyte, James Keane, Julia Eckenberger, Nicholas Anthony, Sandip Shrestha, Daya Marasini, Karrie M. Daniels, Valentina Caputi, Annie M. Donoghue, Mark Lyte
Summary: This study reveals significant differences in cecal microbial community structure, tissue neurochemical concentrations, and gut structural morphologies between birds with different corticosterone responses to stress. Unique neurochemical changes in the intestine following stress suggest a potential relationship between the cecal microbiome and overall avian physiology.
Article
Geriatrics & Gerontology
Eric Tsz Chun Lai, Suzanne C. Ho, Jean Woo
Summary: This study investigated the relationship between social isolation, socioeconomic status, and functional impairment. The results showed that older people with lower socioeconomic status, particularly those with lower income, were at a higher risk of social isolation. However, it was unclear whether social isolation mediated the relationship between socioeconomic status and functional impairment.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Evren Onay Ucar, Aslihan Sengelen, Elif Mertoglu Kamali
Summary: The study reveals that heat shock response (HSR) is closely related to therapeutic resistance of gliomas. Resveratrol (RSV) shows potential as an experimental agent for glioblastoma (GB) therapy, but the role of heat shock proteins (Hsps) in RSV efficacy remains unclear. The findings suggest that silencing Hsp27, Hsp60, Hsp70, and Hsp90 makes glioma cells more sensitive to RSV treatment, making these Hsps potential therapeutic targets for GB treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Javad Mahmoudi, Leila Hosseini, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Mojtaba Ziaee
Summary: The study showed that sericin administration at higher doses can reverse anxiety-like behavior and cognitive deficits induced by heat stress. Sericin may exert its protective effects against heat stress-mediated cognitive dysfunction and anxiety-like behavior possibly through suppressing HSP-70, oxidative stress, and apoptosis.
NEUROCHEMICAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Siti Nadirah Ismail, Elmutaz Atta Awad, Idrus Zulkifli, Yong Meng Goh, Awis Qurni Sazili
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
(2019)
Article
Agriculture, Dairy & Animal Science
Elmutaz Atta Awad, Muhamad Najaa, Zainool Abidin Zulaikha, Idrus Zulkifli, Abdoreza Farjam Soleimani
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
(2020)
Review
Agriculture, Dairy & Animal Science
R. Sanchez-Casanova, L. Sarmiento-Franco, C. J. C. Phillips, Idrus Zulkifli
WORLDS POULTRY SCIENCE JOURNAL
(2020)
Article
Agriculture, Dairy & Animal Science
E. A. Awad, I. Zulkifli, S. K. Ramiah, E. S. Khalil, M. E. Abdallh
Summary: Global warming and food security issues have led to heat stress becoming an emerging problem, causing significant economic losses in the broiler industry. Prebiotics have been shown to mitigate the negative effects of heat stress on broiler chickens by improving intestinal microbiota, physiological stress response, and other pathways.
WORLDS POULTRY SCIENCE JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
Kazeem Ajasa Badmus, Zulkifli Idrus, Goh Yong Meng, Awis Qurni Sazili, Kamalludin Mamat-Hamidi
Summary: Assessment of poultry welfare is crucial for sustainable production in the tropics. Telomere length and regulatory genes have the potential to be novel biomarkers for stress in broiler chickens fed with corticosterone, as demonstrated in this study.
Article
Agriculture, Dairy & Animal Science
Ali Hanafiah Hakim, Idrus Zulkifli, Abdoreza Soleimani Farjam, Elmutaz Atta Awad, Suriyah Kumari Ramiah
Summary: The inclusion of oil at 9.5% in a 20% LPKC/PKC-based diet is necessary to improve nutrient digestibility in broiler chickens, especially in hot and humid tropical regions.
Review
Agriculture, Dairy & Animal Science
Suriya Kumari Ramiah, Krishnan Nair Balakrishnan, Yashini Subramaniam, Oluwaseun Serah Iyasere, Zulkifli Idrus
Summary: Temperature manipulation during embryogenesis enhances the adaptability of chickens to heat stress and regulates the expression of heat stress response genes. Study of heat shock proteins, antioxidants, and immunological genes provides insights into the mechanisms of this adaptability.
Review
Agriculture, Dairy & Animal Science
Krishnan Nair Balakrishnan, Suriya Kumari Ramiah, Idrus Zulkifli
Summary: The demand for poultry production is increasing with the human population, and the importance of heat shock proteins (HSPs) in poultry is discussed in this review. HSPs play a crucial role in helping poultry cope with different stress conditions and maintaining cellular homeostasis. Advances have been made in understanding HSP response to thermal and non-thermal stressors in poultry, and further studies are needed to develop strategies for alleviating the detrimental effects of environmental stresses on poultry.
Article
Agriculture, Dairy & Animal Science
Helen Mitin, Idrus Zulkifli, Muhammad Hazim Che Jamri, Nur Athirah Zamzuri, Nurain Aliah Samian, Aimi Nabilah Hussein, Yong Meng Goh, Awis Qurni Sazili
Summary: Probiotic supplementation can alleviate the stress response and fear-related behaviour in ducks subjected to catching and crating. The procedures of catching and crating may elicit stress and fear reactions in poultry due to human contact and exposure to a novel environment.
Article
Agriculture, Dairy & Animal Science
Ali Hanafiah Hakim, Idrus Zulkifli, Abdoreza Soleimani Farjam, Elmutaz Atta Awad
Summary: The study found that LPKC feed reduced the population of E. coli in the ceca of broiler chickens and serum triglyceride concentration, requiring higher levels of dietary fat to maintain optimal growth performance.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Ahmad Hanafi Sulong, Idrus Zulkifli, Suriya Kumari Ramiah, Eric Lim Teik Chung, Elmutaz Atta Awad, Awis Qurni Sazili
Summary: The study detected APPs in the blood of chicken embryos and neonates for the first time, with levels varying depending on the developmental stage.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Zulkifli Idrus, Nurul Syafiqa Norsam, Muhammad Fahmi Silahuddin, Elmutaz Atta Awad
Summary: The cage rearing system benefits overall performance, FPD incidence, physiological response, and E. coli population in broiler chickens in tropical conditions, while floor pen rearing improves body weight, leg strength, and reduces the caecal Salmonellae population compared to caged broilers.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Ali Hanafiah Hakim, Idrus Zulkifli, Abdoreza Farjam Soleimani, Elmutaz Atta Awad, Norhani Abdullah, Wei Li Chen, Rosfarizan Mohamad
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Mookiah Saminathan, Suriya Kumari Ramiah, Han Ming Gan, Norhani Abdullah, Clemente Michael Vui Ling Wong, Yin Wan Ho, Zulkifli Idrus
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
Suriya Kumari Ramiah, Norhani Abdullah, Muhammad Akhmal, Saminathan Mookiah, Abdoreza Soleimani Farjam, Chen Wei Li, Liang Juan Boo, Zulkifli Idrus
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Sang Hyuck Lee, Mi Ae Kim, Young Chang Sohn
Summary: This study characterized the CCAP signaling system in Pacific abalone and revealed its relationship with the calcium/PKC and cAMP/PKA signal transduction pathways. It provides new insights into the evolutionary origins of the NPS and OT/VP signaling systems in protostomes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Hanna Scheuffele, Erica V. Todd, John A. Donald, Timothy D. Clark
Summary: Global warming is causing an increase in extreme weather events, affecting ecosystems and the behavior of ectotherms. More research is needed to understand the impact of diurnal thermal variability and improve climate change predictions.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Ahmed Badr, Markus Eskelinen, Matti Vornanen
Summary: The acclimatization of certain ectothermic vertebrates to winter conditions involves reduced energy consumption, achieved through decreased movement activity, depression of cellular functions, or switching to anaerobic energy production. This study on crucian carp showed that winter-acclimatized fish exhibited lower metabolic rates and a shift to anaerobic energy production during anoxia. Winter dormancy in crucian carp is achieved through active reduction of energy consumption, a slowed metabolic rate, and a direct response to oxygen absence.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Maria Cruz Sueiro, Cynthia A. Awruch, Gustavo M. Somoza, Walter S. Svagelj, Maria G. Palacios
Summary: According to life-history theory, there might be different immunological strategies between reproductive and non-reproductive periods due to limited resources. Our study on two sympatric marine fish species, rockfish and sandperch, found that reproductive individuals showed lower immune function, but higher levels of natural antibodies in rockfish females, compared to their non-reproductive counterparts. On the other hand, reproductively active sandperch males showed lower levels of natural antibodies and higher neutrophil to lymphocyte ratio and spleen index compared to non-reproductive males. The study highlights the species-specific patterns of immunity and the potential influence of resource limitation and abiotic factors on immune trade-offs in fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
James B. Cummins, Dane A. Crossley II
Summary: This study focuses on cardiovascular development in altricial bird species, which has been less studied compared to precocial species. The researchers investigated the cholinergic and adrenergic receptor mediated control of arterial blood pressure and heart rate in the neotropic cormorant. The findings suggest that both cholinergic and adrenergic tone play a role in cardiovascular regulation in embryonic birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ru Xia, Hong-Kang Liu, Xi-Feng Liu, Xin Deng, Chuan-Jie Qin, Yuan-Fa He, Shi-Mei Lin, Yong-Jun Chen
Summary: This study cloned the genes encoding glucokinase and glucose-6-phosphatase catalytic subunit in largemouth bass, revealing their distribution and transcriptional regulation. The results showed that the functions of G6pc and Gck in LMB were highly conserved in evolution, and the interconversion of glucose and G6P in the liver was well regulated at the transcript level under high starch diet, but a futile cycle was induced after a glucose load.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2024)