期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
卷 161, 期 4, 页码 406-414出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpa.2011.12.014
关键词
Oxidative stress; Methionine oxidation; Hypoxia; Hyperoxia; Antioxidants
资金
- United States-Israel Binational Science Foundation (BSF) [2005346]
- Hadwig Miller Fund
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [2005346] Funding Source: National Science Foundation
The blind subterranean mole rat (Spalax ehrenbergi) exhibits a relatively long life span, which is attributed to an efficient antioxidant defense affording protection against accumulation of oxidative modifications of proteins. Methionine residues can be oxidized to methionine sulfoxide (MetO) and then enzymatically reduced by the methionine sulfoxide reductase (Msr) system. In the current study we have isolated the cDNA sequences of the Spalax Msr genes as well as 23 additional selenoproteins and monitored the activities of Msr enzymes in liver and brain of rat (Rattus norvegicus), Spalax galili, and Spalax judaei under normoxia, hypoxia, and hyperoxia. Under normoxia, the Msr activity was lower in S. galili in comparison to S. judaei and R. norvegicus especially in the brain. The pattern of Msr activity of the three species was similar throughout the tested conditions. However, exposure of the animals to hypoxia caused a significant enhancement of Msr activity, especially in S. galili. Hyperoxic exposure showed a highly significant induction of Msr activity compared with normoxic conditions for R. norvegicus and S. galili brain. It was concluded that among all species examined. S. galili appears to be more responsive to oxygen tension changes and that the Msr system is upregulated mainly by severe hypoxia. (C) 2011 Elsevier Inc. All rights reserved.
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