期刊
ACS NANO
卷 9, 期 7, 页码 6675-6682出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b03269
关键词
RNA nanotechnology; pRNA-quantum dot chimera; biomolecular electronics; nanoscale resistive biomolecular memory; phi29 DNA packaging motor
类别
资金
- Leading Foreign Research Institute Recruitment Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning (MSIP) [2013K1A4A3055268]
- NIH [U01CA151648, R01EB012135]
- William Fairish Endowment Fund
RNA nanotechnology offers advantages to construct thermally and chemically stable nanoparticles with well-defined shape and structure. Here we report the development of an RNA-QD (quantum dot) chimera for resistive biomolecular memory application. Each QD holds two copies of the pRNA three-way junction (pRNA-3WJ) of the bacteriophage phi29 DNA packaging motor. The fixed quantity of two RNAs per QD was achieved by immobilizing the pRNA-3WJ with a Sephadex aptamer for resin binding. Two thiolated pRNA-3WJ serve as two feet of the chimera that stand on the gold plate. The RNA nanostructure served as both an insulator and a mediator to provide defined distance between the QD and gold. Immobilization of the chimera nanoparticle was confirmed with scanning tunneling microscopy. As revealed by scanning tunneling spectroscopy, the conjugated pRNA-3WJ-QD chimera exhibited an excellent electrical bistability signal for biomolecular memory function, demonstrating great potential for the development of resistive biomolecular memory and a nano-bio-inspired electronic device for information processing and computing.
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