期刊
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
卷 21, 期 7, 页码 526-532出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1386207321666180828092546
关键词
Ionic liquid; solvent-free conditions; chlorosulfonic acid; N, N, N ', N '-tetramethylethylenediamine; 1, 8-dioxo-octahydroxanthenes; aryl aldehyde; dimedone
Aim and Objective: In this work, we synthesized and characterized a novel Bronsted acidic ionic liquid from the reaction of N, N, N', N'-tetramethylethylenediamine with chlorosulfonic acid and explored its catalytic activity in 1, 8-dioxo-octahydroxanthenes synthesis. Materials and Methods: Dimedone, aryl aldehydes, and the ionic liquid as the catalyst were reacted under solvent-free conditions. The progressive of the reaction was monitored by a thin layer of chromatography (ethyl acetate/n-hexane = 1/5). All products were characterized as the basis of their spectra data and melting point by comparison with those reported in the literature. Results: The prepared ionic liquid was successfully applied in the synthesis of 1, 8-dioxooctahydroxanthenes in good to high yields on the reaction of aryl aldehyde and dimedone at 120 degrees C under solvent-free conditions. Conclusion: This research demonstrates that the catalyst is impressive for 1, 8-dioxo-octahydroxanthenes synthesis under solvent-free conditions.
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