期刊
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
卷 12, 期 8, 页码 752-759出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138620709789104924
关键词
High throughput screening; acetyl-coenzyme A carboxylase; RapidFire; mass spectrometry
In this review various technologies and approaches for the utilization of mass spectrometry in high throughput analyses are discussed. The use of quadrupole-based mass spectrometry in the screening of chemical libraries against enzymatic targets for the identification of inhibitors and/or activators is highlighted. The RapidFire mass spectrometry system, an integrated on-line solid-phase extraction system interfaced to a triple-quadrupole mass spectrometer is described in detail, and the identification of a series of inhibitors of the acetyl-coenzyme A carboxylase (ACC) assay is described.
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