Article
Gastroenterology & Hepatology
Pr. Benoit Coffin, Henri Duboc
Summary: Persistent abdominal pain is a challenging condition often misdiagnosed as functional disorders. This article provides an update on less well-known causes of abdominal pain and their diagnosis and management.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Xiu-Cai Fang, Wen-Juan Fan, Douglas D. Drossman, Shao-Mei Han, Mei-Yun Ke
Summary: This study compared bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain & discomfort. The results showed that IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yuqin He, Yan Tan, Jianru Zhu, Xiaofeng Wu, Zhiyong Huang, Hengsheng Chen, Min Yang, Dongfeng Chen
Summary: The study found a clear positive correlation between the level of IRAK1 and visceral hypersensitivity in IBS models, and treatment with sodium butyrate could alleviate visceral hypersensitivity by inhibiting the expression of IRAK1.
Review
Pharmacology & Pharmacy
Michael Camilleri, Saam Dilmaghani
Summary: This narrative review provides an update on current approaches for the treatment of pain, global symptoms, or relief in irritable bowel syndrome (IBS). The review evaluates medications, dietary interventions, fecal microbial transplantation (FMT), electrical approaches, and behavioral therapies. The evidence suggests only modest benefit in global IBS symptoms and pain relief. A future approach involving validated biomarkers could individualize treatment and improve outcomes.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Antonina Mikocka-Walus, Yan Yiannakou, Lesley A. Houghton, Christopher J. Black, Alexander C. Ford
Summary: The prognosis of individuals with Rome IV-defined IBS worsens according to incremental increases in psychological comorbidity. This finding has significant implications for clinical practice and research.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Brennan M. R. Spiegel, Omer Liran, Rebecca Gale, Carine Khalil, Katherine Makaroff, Robert Chernoff, Tiffany Raber, Bianca Chang, Nipaporn Pichetshote, Ali Rezaie
Summary: This study provides initial validation of IBS/VR, the first virtual reality program designed for IBS, which allows patients to self-practice therapeutic techniques and incorporates patient feedback for improvement.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Alexandra Aupetit, Sebastien Grigioni, Horace Roman, Moise Coeffier, Amelie Breant, Clotilde Hennetier, Najate Achamrah
Summary: This study found a significant association between irritable bowel syndrome (IBS), eating disorders (ED), and endometriosis. The prevalence of IBS and ED in patients with endometriosis was higher than in the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Grace L. Burns, Nicholas J. Talley, Simon Keely
Summary: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by chronic abdominal pain and altered defaecation. Research has found that small intestinal mechanosensation, altered barrier functions, and microbial imbalance are associated with IBS. The current literature suggests that the pathogenesis of IBS may involve dysfunction of the entire intestinal tract.
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Mustafa Abdul Karim, Nadeen Al-Baz, Peter M. Haddad, Shuja M. Reagu, Majid Alabdulla
Summary: This case study suggests that buspirone is effective in treating refractory IBS. Further research is needed to evaluate the role of buspirone in IBS management.
Review
Immunology
Javier Aguilera-Lizarraga, Hind Hussein, Guy E. Boeckxstaens
Summary: Irritable bowel syndrome is a chronic gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. Immune activation plays an important role in the development of irritable bowel syndrome, particularly through the release of immune mediators by mast cells, which directly activate or sensitize pain-transmitting nerves, leading to abdominal pain symptoms.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jan K. Nowak, Cyntia J. Szymanska, Jaroslaw Walkowiak
Summary: In this study, an unsupervised differential correlation network reanalysis of rectal transcriptomic data revealed promising targets for mechanistic research of intestinal pathology in cystic fibrosis (CF), including FAU, SRP14, and GDI2. These genes may be involved in a compensatory protein trafficking mechanism in the CF rectum, highlighting their potential therapeutic value.
Editorial Material
Physiology
Karolina Wielgus, Mikolaj Danielewski, Jaroslaw Walkowiak
Review
Genetics & Heredity
Mikolaj Danielewski, Joanna Zuraszek, Aleksandra Zielinska, Karl-Heinz Herzig, Ryszard Slomski, Jaroslaw Walkowiak, Karolina Wielgus
Summary: Paleogenetics has undergone significant changes since its inception. Initially, limited molecular techniques hindered ancient DNA analysis. However, advancements in scientific tools, as well as the popularity of this field, have led to remarkable achievements. Breakthroughs in next-generation sequencing technologies and DNA isolation protocols have enabled the sequencing of whole genomes even from highly fragmented aDNA samples.
Article
Pharmacology & Pharmacy
Szymon Sip, Anna Gosciniak, Piotr Szulc, Jaroslaw Walkowiak, Judyta Cielecka-Piontek
Summary: Five varieties of Actinidia leaves were analyzed, and Ken's Red was found to have the highest biological activity. The use of cyclodextrins as extraction process enhancers significantly increased the extraction of active compounds and improved the leaf activity of Ken's Red.
Article
Food Science & Technology
Krzysztof Dziedzic, Szymon Kurek, Grazyna Podolska, Slawomira Drzymala-Czyz, Sylwia Mildner-Szkudlarz, Wei Sun, Jaroslaw Walkowiak
Summary: This study investigated the content of phytosterols, squalene, and tocopherols in four varieties of common buckwheat grains and analyzed the effects of different tillage and nitrogen doses on grain yield and composition.
Article
Pediatrics
Jan Brylak, Jan K. K. Nowak, Mariusz Szczepanik, Magdalena Holubiec, Pawel Kurzawa, Jaroslaw Walkowiak
Summary: In children, there is a positive correlation between blood eosinophil count and colonic eosinophil mucosal density. This association is more pronounced in patients with systemic inflammation and older than 12.4 years.
Article
Medicine, General & Internal
Urszula Daniluk, Paulina Krawiec, Elzbieta Pac-Kozuchowska, Lukasz Dembinski, Jan Stanislaw Bukowski, Aleksandra Banaszkiewicz, Anna Wozniuk-Kazmierczak, Elzbieta Czkwianianc, Jan Brylak, Jaroslaw Walkowiak, Agnieszka Borys-Iwanicka, Anna Kofla-Dlubacz, Tomasz Pytrus, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn
Summary: The coexistence of inflammatory bowel disease (IBD) with pancreatic pathology is rare in children. A retrospective analysis of data from 1538 children diagnosed with IBD in 2014-2021 found that 11.4% of them had pancreatic involvement (PI), with acute pancreatitis (AP) diagnosed in 43.8% and asymptomatic hyperlipasemia (HL) or hyperamylasemia (HA) observed in 50.0%. Routine monitoring of pancreatic enzymes should be performed in patients with IBD, especially after the initiation of azathioprine (AZA) treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Emilia Dybska, Jan Krzysztof Nowak, Jaroslaw Walkowiak
Summary: The study investigates the transcriptomic context of RUNX3 expression in blood monocytes and reveals its strong associations with genes involved in cell growth, signal transduction, and chromosome organization. The findings suggest that RUNX3 plays a role in regulating cell function and immune response.
Article
Biochemistry & Molecular Biology
Anna Gosciniak, Piotr Szulc, Waldemar Zielewicz, Jaroslaw Walkowiak, Judyta Cielecka-Piontek
Summary: Red clover, a raw material with isoflavone content, was studied to evaluate the properties of its leaves and flowers. The study found that the ability to inhibit α-glucosidase, lipase, collagenase and antioxidant activity was not correlated with isoflavone content.
Review
Health Care Sciences & Services
Kamila Bokayeva, Malgorzata Jamka, Michalina Banaszak, Aleksandra Makarewicz-Bukowska, Ada Adamczak, Maria Chrobot, Adrianna Janicka, Natalia Jaworska, Jaroslaw Walkowiak
Summary: Folic acid may have a positive effect on endothelial function but may not affect arterial stiffness. Further studies are needed to confirm these results.
Article
Medicine, General & Internal
Malgorzata Jamka, Agata Czochralska-Duszynska, Edyta Madry, Aleksandra Lisowska, Katarzyna Jonczyk-Potoczna, Judyta Cielecka-Piontek, Pawel Bogdanski, Jaroslaw Walkowiak
Summary: This study aimed to evaluate the effects of CLA supplementation on bone mineral density and content in overweight or obese women. The results showed that three-month CLA supplementation did not improve bone health in this population. However, long-term intervention studies are needed to further investigate the potential benefits of CLA on bone health.
MEDICINA-LITHUANIA
(2023)
Review
Health Care Sciences & Services
Aleksandra Makarewicz, Malgorzata Jamka, Jakub Geltz, Angelika Smidowicz, Marta Kokot, Nina Kaczmarek, Edyta Madry, Jaroslaw Walkowiak
Summary: This meta-analysis compared the effects of endurance, strength, and combined training on inflammatory markers and adipokine concentrations in overweight and obese adults. The findings suggest that endurance training is more effective than strength training in reducing CRP, IL-6, and visfatin concentrations, while combined training is more beneficial in reducing TNF-alpha levels. There were no differences between the effects of different types of training on adiponectin and leptin concentrations. Further studies are needed to determine the optimal training for adiponectin and leptin concentrations in this population.
Review
Health Care Sciences & Services
Maria Wasiewicz-Gajdzis, Malgorzata Jamka, Jakub Geltz, Kamila Bokayeva, Lukasz Kaluzny, Joanna Jaglowska, Jaroslaw Walkowiak
Summary: This study compared the anthropometric parameters of patients with fatty acid oxidation disorders (FAOD) and healthy controls, finding a higher prevalence of abnormal body weight (overweight and obesity) in the FAOD group. Significant differences in body weight percentiles, BMI, BMI percentiles, and BMI z-scores were observed between FAOD patients and controls in the cohort. However, the meta-analysis did not show any differences in weight and BMI in all tested subgroups. Caution should be exercised when interpreting these results due to the low quality of evidence, small sample sizes, and significant heterogeneity of the included data.
Article
Health Care Sciences & Services
Malgorzata Jamka, Sylwia E. Piotrowska-Brudnicka, Joanna Karolkiewicz, Damian Skrypnik, Pawel Bogdanski, Judyta Cielecka-Piontek, Gulnara Sultanova, Jaroslaw Walkowiak, Edyta Madry
Summary: This pilot study compared the effect of endurance and endurance-strength training on body composition and bone metabolism in centrally obese women, with endurance-strength training showing more effectiveness in increasing lean mass.
Article
Social Sciences, Interdisciplinary
Piotr Przymuszala, Lucja Zielinska-Tomczak, Michal Klos, Angelika Kowalska, Paulina Birula, Martyna Piszczek, Magdalena Cerbin-Koczorowska, Ryszard Marciniak
Summary: The transition to online learning during the COVID-19 pandemic was generally well-received by Polish healthcare students, who appreciated the time efficiency, student-friendliness, and unlimited attention from teachers that online learning provided. They also recognized the flexibility and improved learning conditions, but identified drawbacks such as internet and technical issues, teacher attitudes, limited interpersonal relations, and limitations in learning practical skills.