Article
Pharmacology & Pharmacy
Florina Veider, Zeynep Burcu Akkus-Dagdeviren, Patrick Knoll, Andreas Bernkop-Schnuerch
Summary: In this study, PEG-free and zeta potential changing lipid-based nanocarriers were developed to enhance cellular uptake. The results showed that the nanocarriers released phosphate under intestinal alkaline conditions through polyphosphate coating, resulting in significant zeta potential changes and improved cellular uptake.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Patrick Knoell, Nikolas Hormann, Nguyet-Minh Nguyen Le, Richard Wibel, Ronald Gust, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop nanostructured lipid carriers (NLCs) decorated with a polycationic cell-penetrating peptide (CPP) and coated with polyphosphates (PP) for charge conversion. The results showed that the modified NLCs had improved drug loading and endosomal escape properties, as well as increased mucus diffusion ability.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Environmental Sciences
Anna Mittag, Christian Hoera, Alexander Kaempfe, Martin Westermann, Jochen Kuckelkorn, Thomas Schneider, Michael Glei
Summary: The study found that zinc oxide nanoparticles of different sizes have cellular uptake and toxic effects on human intestinal cells, especially showing cytotoxicity at high concentrations, which can accelerate cell apoptosis and death.
Article
Environmental Sciences
Yaxuan Liu, Qingying Shi, Xiaomei Liu, Lan Wang, Yuhe He, Jingchun Tang
Summary: This study investigated the toxic effects of PS particles and PFOS on human colon adenocarcinoma cells in vitro, revealing that the presence of PFOS increased cell uptake of PS nanoparticles and elucidated the toxic mechanism. This provides important insights for assessing the risk of combined pollution of MNPs and PFOS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Remya Valsalakumari, Sunil Kumar Yadava, Marzena Szwed, Abhilash D. Pandya, Gunhild Mari Maelandsmo, Maria Lyngaas Torgersen, Tore-Geir Iversen, Tore Skotland, Kirsten Sandvig, Jyotsnendu Giri
Summary: The study found that LNCs-PTX were taken up by MDA-MB-468 cells more effectively than the other two cell lines. Additionally, the cytotoxicity of LNCs-PTX on cells was primarily attributed to endocytosis mechanisms involving Cdc42/GRAF-dependent endocytosis and macropinocytosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zhenqi Liu, Alison B. Lansley, Tu Ngoc Duong, John D. Smart, Ananth S. Pannala
Summary: This study investigated the potential of novel polymer-surfactant-based formulations to improve the solubility and permeability of curcumin. The results showed that formulation A, containing Soluplus (R) and vitamin E TPGs, significantly increased the permeation and cellular uptake of curcumin compared to other samples.
Article
Biochemistry & Molecular Biology
Mayuko Itaya, Taiki Miyazawa, Saoussane Khalifa, Naoki Shimizu, Kiyotaka Nakagawa
Summary: The study found that some food compounds binding stronger to albumin than curcumin can enhance the physiological activity of curcumin. Experimental results confirmed this hypothesis, providing insights into enhancing the physiological activities of various food compounds by focusing on their interaction with albumin.
Article
Biochemistry & Molecular Biology
Mohammed Iddir, Juan Felipe Porras Yaruro, Emmanuelle Cocco, Emilie M. Hardy, Brice M. R. Appenzeller, Cedric Guignard, Yvan Larondelle, Torsten Bohn
Summary: The study found that co-digestion of commonly consumed proteins with carotenoid-rich foods can improve the bioaccessibility and cellular uptake of carotenoids, especially in the presence of soy protein isolate (SPI). Meat proteins (turkey and cod) had a weaker impact on carotenoids.
Article
Chemistry, Multidisciplinary
Evren Gundogdu, Emine-Selin Demir, Meliha Ekinci, Emre Ozgenc, Derya Ilem-Ozdemir, Zeynep Senyigit, Isabel Gonzalez-Alvarez, Marival Bermejo
Summary: Imatinib-loaded nanostructured lipid carrier system (F16-IMT) was successfully developed and characterized in this study. The F16-IMT formulation exhibited small particle size, stability, and efficient drug release. It also showed good cellular uptake and cytotoxicity against CRL-1739 cells. These findings suggest that F16-IMT has the potential to be an effective treatment for GIST.
Article
Multidisciplinary Sciences
Patrick M. Perrigue, Agata Henschke, Bartosz F. Grzeskowiak, Lucja Przysiecka, Kaja Jaskot, Angelika Mielcarek, Emerson Coy, Sergio E. Moya
Summary: Understanding the interaction between nanoparticles and cells is crucial for designing more effective nanomedicines. This study investigates the biological fate of silica nanoparticles in senescent cells, which do not divide, using various methods including microscopy and flow cytometry. The results show that the nanoparticles readily enter the senescent cells and accumulate in the cytoplasm for a long time. This study lays the foundation for the development of NP-based tools for detecting and targeting senescent cells for therapeutic purposes.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Vijay M. Kumbar, Uday Muddapur, Abdullatif Bin Muhsinah, Saad Ali Alshehri, Mohammed Merae Alshahrani, Ibrahim Abdullah Almazni, Manohar S. Kugaji, Kishore Bhat, Malleswara Rao Peram, Mater H. Mahnashi, Sameer J. Nadaf, Sheetalnath B. Rooge, Aejaz Abdullatif Khan, Ibrahim Ahmed Shaikh
Summary: Oral cancer has a high mortality rate and chemotherapy is the preferred treatment, but drug resistance limits its effectiveness. This study found that curcumin nanomicelles can improve the therapeutic effects of curcumin in treating cisplatin-resistant oral cancer.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Multidisciplinary Sciences
Yiming Ruan, Zheng Zhong, Xin Liu, Ziwei Li, Junxian Li, Lili Sun, Hou Sen
Summary: The cytotoxicity of micro/nanoplastics (MNPs) is strongly influenced by particle size, with smaller MNPs being more easily internalized by HeLa cells. Larger MNPs cannot enter cells at all. The toxic effect of MNPs on cell activity is dose-dependent and only observed in MNPs that can be internalized by cells. The size-dependent cytotoxicity of MNPs is attributed to increased reactive oxygen species (ROS) level and abnormal gene expression.
Article
Nanoscience & Nanotechnology
Yaru Zou, Wei Gao, Huizhen Jin, Chenmei Mao, Yi Zhang, Xiaoling Wang, Dong Mei, Libo Zhao
Summary: The present study investigates the uptake and trafficking mechanisms of 6-MP nanomedicines. The results demonstrate that 6-MP nanomedicines enhance oral bioavailability through multiple pathways, including active transport, paracellular transport, lymphatic delivery, and MRP4 transporter. These findings shed light on the cellular uptake and transcellular trafficking mechanisms of oral nanomedicines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Xue Li, Fan Xu, Donglei Yang, Pengfei Wang
Summary: A fusion protein was designed to enhance the cellular uptake efficiency and in vivo retention time of DNA nanostructures in cancer cells and mice, showing potential for facilitating the biological applications of DNA nanostructures.
Article
Pharmacology & Pharmacy
Leila Gholami, Amir Abbas Momtazi-Borojeni, Bizhan Malaekeh-Nikouei, Banafsheh Nikfar, Farjad Amanolahi, Ali Mohammadi, Reza Kazemi Oskuee
Summary: This study aimed to develop liposome formulations based on soybean phosphatidylcholine (SPC) and hydrogenated SPC (HSPC) to enhance the bioavailability of curcumin in bladder cancer cells. The results indicated that curcumin could be efficiently encapsulated in the HSPC and SPC liposome formulations, which showed stability and sustained drug release. Additionally, the liposomal curcumin formulations significantly increased the cellular uptake and cytotoxicity on bladder cancer cells.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Pharmacology & Pharmacy
Jaspreet Kaur, Rupinder Kaur Sodhi, Jitender Madan, Simerjeet Kaur Chahal, Ravinder Kumar
PHARMACOLOGICAL REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Meenu Nagpal, Manjot Kaur, Deepika Sharma, Ashish Baldi, Ramesh Chandra, Jitender Madan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Review
Oncology
Jonathan W. Rick, Ankush Chandra, Cecilia Dalle Ore, Alan T. Nguyen, Garima Yagnik, Manish K. Aghi
SEMINARS IN ONCOLOGY
(2019)
Review
Oncology
Jonathan W. Rick, Maryam Shahin, Ankush Chandra, Cecilia Dalle Ore, John K. Yue, Alan Nguyen, Garima Yagnik, Soumya Sagar, Saman Arfaie, Manish K. Aghi
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2019)
Review
Neurosciences
Wenjing Wei, Di Wu, Yunxia Duan, Kenneth B. Elkin, Ankush Chandra, Longfei Guan, Changya Peng, Xiaoduo He, Chuanjie Wu, Xunming Ji, Yuchuan Ding
Article
Oncology
Ankush Chandra, Arman Jahangiri, William C. Chen, Alan T. Nguyen, Garima Yagnik, Matheus P. Pereira, Saket Jain, Joseph H. Garcia, Sumedh S. Shah, Harsh Wadhwa, Rushikesh S. Joshi, Jacob Weiss, Kayla J. Wolf, Jung-Ming G. Lin, Soren Mueller, Jonathan W. Rick, Aaron A. Diaz, Luke A. Gilbert, Sanjay Kumar, Manish K. Aghi
Article
Clinical Neurology
Ankush Chandra, Michael G. Brandel, Harsh Wadhwa, Neil D. Almeida, John K. Yue, Mohammed O. Nuru, Justin Cheng, Shannon Lu, Akshar Patel, Walid Ibn Essayed, Michael W. McDermott, Mitchel S. Berger, Manish K. Aghi
WORLD NEUROSURGERY
(2020)
Letter
Clinical Neurology
Ankush Chandra, Yazeed W. Haddad, Cole T. Lewis, Jordan Spatz, Diego Carrera, Manish K. Aghi
WORLD NEUROSURGERY
(2020)
Letter
Clinical Neurology
Ankush Chandra, Matheus P. Pereira, Manish K. Aghi
WORLD NEUROSURGERY
(2020)
Letter
Clinical Neurology
Ankush Chra, Manish K. Aghi
WORLD NEUROSURGERY
(2020)
Editorial Material
Clinical Neurology
Antonio Dono, Ankush Chandra, Leomar Y. Ballester, Yoshua Esquenazi
Article
Clinical Neurology
Karam Asmaro, Hassan A. Fadel, Sameah A. Haider, Jacob Pawloski, Edvin Telemi, Tarek R. Mansour, Ankush Chandra, Michael Bazydlo, Adam M. Robin, Ian Y. Lee, Ellen L. Air, Jack P. Rock, Steven N. Kalkanis, Jason M. Schwalb
Summary: A targeted educational intervention successfully reduced excessive opioid prescribing after intracranial surgery without affecting patient satisfaction or analgesic effect. This simple, evidence-based intervention highlights the ability to impact clinical decision-making, reduce potential patient harm, and address national public health concerns.
Article
Medicine, Research & Experimental
Darryl Lau, Harsh Wadhwa, Sweta Sudhir, Alexander Chih-Chieh Chang, Saket Jain, Ankush Chandra, Alan T. Nguyen, Jordan M. Spatz, Ananya Pappu, Sumedh S. Shah, Justin Cheng, Michael M. Safaee, Garima Yagnik, Arman Jahangiri, Manish K. Aghi
Summary: The study found that the c-Met/beta 1 complex plays a crucial role in promoting intravasation and vessel wall adhesion of triple-negative breast cancer cells, potentially increasing mesenchymal and stem cell characteristics. Therapeutic approaches targeting this complex can reduce invasion and metastasis of breast cancer cells, as well as decrease the risk of bone metastases.
Article
Clinical Neurology
Ankush Chandra, G. Michael Brandel, Harsh Wadhwa, P. Matheus Pereira, T. Cole Lewis, W. Yazeed Haddad, M. Victor Lu, D. Neil Almeida, O. Mohammed Nuru, Yoshua Esquenazi, K. Manish Aghi
Summary: The study found that FMGs from the top six feeder countries (TFC) had higher success rates and better academic performance in matching into US neurosurgery programs. Compared to FMGs from non-top feeder countries (NTFC), TFC FMGs were more likely to come from major feeder schools, have higher H-indices and publication numbers.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Letter
Clinical Neurology
Ankush Chandra, Michael G. Brandel, Manish K. Aghi
WORLD NEUROSURGERY
(2020)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)