Article
Nanoscience & Nanotechnology
Julia Nowak-Jary, Beata Machnicka
Summary: Magnetic iron oxide nanoparticles have broad potential applications in medical and biological sciences. They can be used in targeted drug delivery, internal radiotherapy, magnetic resonance imaging, hyperthermia, and radiolabelling. The appropriate design of nanoparticles allows them to be delivered to desired tissues and organs, with an external magnetic field increasing their biodistribution. Factors such as size, shape, surface charge, coating molecules, and route of administration affect their biodistribution. Modern techniques can determine nanoparticle accumulation sites and concentration in isolated tissues or the body in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Samia Aboushoushah, Wafa Alshammari, Reem Darwesh, Nihal Elbaily
Summary: The study suggests that curcumin-coated iron oxide nanoparticles (Cur-IONPs) exhibit good safety and non-toxicity in a mouse model. Cur-IONPs primarily accumulate in the liver, spleen, and brain, with minimal presence in the kidney, and can be completely cleared after a certain period of time.
Article
Chemistry, Multidisciplinary
Sofia Papadopoulou, Argiris Kolokithas-Ntoukas, Evangelia-Alexandra Salvanou, Anastasios Gaitanis, Stavros Xanthopoulos, Konstantinos Avgoustakis, Maria Gazouli, Maria Paravatou-Petsotas, Charalampos Tsoukalas, Aristides Bakandritsos, Penelope Bouziotis
Summary: The study aimed to develop a bioimaging probe using magnetic iron oxide nanoparticles (MIONs) labeled with Gallium-68, showing high radiolabeling efficiency and low toxicity against human cells. The MIONs exhibited strong magnetic properties and potential application as tracers for early cancer detection.
Article
Biochemistry & Molecular Biology
Heba M. Fahmy, Taiseer M. Abd El-Daim, Omnia A. Ali, Asmaa A. Hassan, Faten F. Mohammed, Mohamed M. Fathy
Summary: The study found that iron mainly accumulated in the liver tissue, with the lowest liver accumulation observed after administration of Cit-IONPs or CS-IONPs. Administration of CS-IONPs showed the highest spleen iron accumulation, while the ferrous sulfate-treated group exhibited the highest kidney iron accumulation. Histopathological examination indicated that toxicity was more prevalent in groups treated with Cit-IONPs or commercial FeSO4, with Cur-IONPs and CS-IONPs showing milder toxicity at the same doses.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ivan Zelepukin, Alexey Yaremenko, Ilya N. Ivanov, Mikhail Yuryev, Vladimir R. Cherkasov, Sergey M. Deyev, Petr Nikitin, Maxim P. Nikitin
Summary: Safe application of nanoparticles in medicine requires a full understanding of their pharmacokinetics and degradation in the organism. In this study, a magnetic spectral approach was used for in vivo monitoring of magnetic particle degradation, revealing the significant influence of parameters such as dose, size, surface coating, and internal architecture on the degradation process. These findings provide deeper insights into particle degradation in vivo, potentially facilitating the rational design of nano- and microparticles with predictable long-term fate in vivo.
Article
Pharmacology & Pharmacy
Alberto Curcio, Aurore Van de Walle, Christine Pechoux, Ali Abou-Hassan, Claire Wilhelm
Summary: This study investigates the bioassimilation of nanoparticles in the body and demonstrates that copper sulfide nanoparticles do not have adverse effects on organ weight and metal homeostasis. This result provides support for the potential clinical application of these nanomaterials.
Article
Nanoscience & Nanotechnology
Lilianne Beola, Valeria Grazu, Yilian Fernandez-Afonso, Raluca M. Fratila, Marcelo de las Heras, Jesus M. de la Fuente, Lucia Gutierrez, Laura Asin
Summary: The study utilized magnetic hyperthermia for the treatment of pancreatic cancer, finding that optimal alternating magnetic field conditions can enhance cell viability. In vivo experiments revealed the relationship between the distribution of magnetic nanoparticles within tumor tissue and treatment effectiveness. The conclusion highlights the importance of considering particle biodistribution in improving the efficacy of magnetic hyperthermia for pancreatic cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Yadileiny Portilla, Yilian Fernandez-Afonso, Sonia Perez-Yague, Vladimir Mulens-Arias, M. Puerto Morales, Lucia Gutierrez, Domingo F. Barber
Summary: This study analyzed the biodistribution, organ accumulation and degradation of different coatings of iron oxide magnetic nanoparticles (MNPs) in vivo. The results showed that the coating influenced the proportion of MNPs in different organs, with faster degradation in the liver regardless of the coating. This information is important for choosing the optimal coating for specific biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
B. S. Unnikrishnan, G. U. Preethi, T. T. Sreelekha
Summary: The emergence of nanotechnology has revolutionized cancer therapy, with polysaccharide-based nanoparticles showing promise in drug delivery due to their high drug encapsulation efficiency, protection against degradation, controlled release, and cellular internalization capabilities. The fabricated doxorubicin-loaded carboxymethylated PST001 coated iron oxide nanoparticles have been found to be effective in targeted drug delivery for cancer management.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Materials Science, Ceramics
M. Imran, Saira Riaz, Tanzeela Batool, Amreen Qamar, Irfan Ullah Khan, Rizwana Zahoor, Abubaker Shahid, Shahzad Naseem
Summary: The study aims to evaluate the cytotoxicity and biodistribution of iron-oxide-stabilized zirconia nanoparticles with honey as a capping agent. The nanoparticles were prepared using microwave-assisted sol-gel method and their properties, such as magnetic and radioactivity, were investigated. The biodistribution of the nanoparticles in rabbits showed potential for tumor therapy, with high uptake observed in the bladder.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Pyeong Seok Choi, Jun Young Lee, Seung Dae Yang, Jeong Hoon Park
Summary: A novel chelator-free Zr-89-IONC with rice-shaped morphology was developed and coated with polyethyleneimine (PEI) and polyvinylpyrrolidone (PVP) to improve cancer targeting efficacy. Positron emission tomography measurements confirmed that only PVP-coated Zr-89-IONC reached the tumor region, while non-coated and PEI coated ones tended to be cleared in the liver and spleen. The Zr-89-incorporated iron oxide nanocomposite showed stability for radiolabeling, making it a potential carrier for specific cancer cell targeting.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Polymer Science
Moises Bustamante-Torres, David Romero-Fierro, Jocelyne Estrella-Nunez, Belen Arcentales-Vera, Estefani Chichande-Proano, Emilio Bucio
Summary: In recent years, a wide range of nanomaterials, including magnetic nanoparticles, have been extensively studied for various purposes. Iron oxide nanoparticles and superparamagnetic iron oxide nanoparticles have attracted significant attention due to their physicochemical and magnetic properties, as well as their compatibility with organic or inorganic compounds. The incorporation of these nanoparticles into hydrogels has garnered interest in the field of biomedicine. This review discusses various synthesis methods for magnetite nanoparticles and introduces different processing techniques for magnetite-based nanocomposites in hydrogels. The characterization techniques commonly used to study magnetic nanoparticles and magnetic gels are also discussed.
Article
Materials Science, Multidisciplinary
Antonella Antonelli, Mauro Magnani
Summary: SPION have been approved for human use and are now moving towards more complex structures optimized for different imaging modalities and therapeutic applications, thanks to the contributions of Prof. Krishnan M. Kannan in understanding the role of various parameters in shaping SPIO function. New cell-based SPIO constructs have also been optimized to maintain biocompatibility and prevent cell damage while maintaining cell functionality.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Physics, Applied
Zhongze Guo, Yong Hu
Summary: We conducted a numerical study on the magnetization behavior of self-assembled magnetite magnetic nanoparticles (MNPs) with diameters of 10 and 14 nm at room temperature using molecular dynamics simulations. The results showed that, in the absence of a magnetic field, isotropic growth of nano-sheets or nano-chains resulted in zero magnetization. Under a constant magnetic field, self-assembly occurred and the magnetization of the MNPs was found to be maximized at 0.05 T and decreased monotonically with increasing magnetic field strength. The arrangement of MNPs and their magnetic dipole orientations aligned with the magnetic field direction under weak magnetic fields, favoring the formation of long nano-belts and nano-chains. However, under strong magnetic fields, small nano-sheets and short nano-chains with different magnetic dipole orientations were formed. These results were attributed to the competition between magnetic dipole-dipole interaction and the magnetic field, with the critical separation between MNPs depending on their diameter and magnetic field strength.
APPLIED PHYSICS LETTERS
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
