期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 117, 期 -, 页码 330-337出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.02.036
关键词
Liposomes; Pectin; Vitamin C; Storage stability; Skin permeation
资金
- National Natural Science Foundation of China [21266021]
- Project of State Key Laboratory of Food Science and Technology, Nanchang University [SKLF-ZZB-201311]
A transdermal drug delivery system was prepared by high methoxyl pectin (HMP) or low methoxyl pectin (LMP) coated vitamin C liposomes. HMP coated vitamin C liposomes (HMP-L) and LMP coated vitamin C liposomes (LMP-L) exhibited an increase in average diameter (from 66.9 nm to 117.3 nm and 129.6 nm, respectively), a decrease in zeta potential (from -2.3 mV to -23.9 mV and -35.5 mV, respectively), and a similar entrapment efficiency (48.3-50.1%). Morphology and FIR analysis confirmed that pectin was successfully coated on the surface of vitamin C liposomes mainly through the hydrogen bonding interactions. Besides, HMP-L and LMP-L exhibited an obvious improvement in storage stability, with lower aggregation, oxidation of lipid and leakage ratio of vitamin C from liposomes, and LMP-L showed better physicochemical stability than HMP-L. Moreover, skin permeation of vitamin C was improved 1.7-fold for HMP-L and 2.1-fold for LMP-L after 24h, respectively, compared with vitamin C nanoliposomes. Therefore, this study suggested that pectin coated liposomes, especially the LMP-L, could be a promising transdermal drug delivery system with better storage stability and skin permeation. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据