期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 115, 期 -, 页码 237-243出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2013.11.045
关键词
Dendrimer; Triclosan; Remineralization; Drug release; Human dentine
资金
- National Natural Science Foundation of China [51322303, 81170958]
- Fok Ying Tung Education Foundation [122034]
- Program for New Century Excellent Talents in University [NCET-10-0592]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
- Science & Technology Foundation of Sichuan Province [2012JQ0009, 2011SZ0130]
- Fundamental Research Funds for the Central Universities [2010SCU22001, 2011SCU04A04]
- Natural Science Foundation of Jiangsu Province [BK2010248, BK2011340]
In order to treat dental caries of damaged dentine, triclosan-loaded carboxyl-terminated poly(amido amine) dendrimer (PAMAM-COOH) is prepared and characterized. While being incubated in artificial saliva, triclosan-loaded PAMAM-COOH formulation can induce in situ remineralization of hydroxyapatite (HA) on etched dentine, and the regenerated HA has a similar crystal structure with natural dentine. It can also release the encapsulated triclosan for a long period. The interesting drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree, which are ideal to obtain multifunctional properties of long-term release of anti-bacterial drug for local treatment during the remineralization process. The triclosan-loaded G4-COOH provides a general strategy to cure dental caries and repair damaged dentine at the same time, which forms a potential restorative material for dental repair. (C) 2013 Elsevier B.V. All rights reserved.
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