期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 123, 期 -, 页码 403-412出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.09.050
关键词
Implant-associated infection; Cementless arthroplasty; Drug delivery system; Biocoating; Biofilm prevention
资金
- Key Disciplines of Shanghai Municipal Education Commission [J50206]
- Natural Science Foundation of China [51002095, 51372152, 30973038]
- Science and Technology Commission of Shanghai Municipality [12JC1405600]
- Program of Shanghai Normal University [DZL124, DCL201303]
- Innovation Foundation of Shanghai Education Committee [14ZZ124]
Postoperative implant-associated infection remains a serious complication in total joint arthroplasty (TJA) surgery. The addition of antibiotics to bone cement is used as an antimicrobial prophylaxis in cemented joint arthroplasty; however, in cementless arthroplasty, there are no comparable measures for the local delivery of antibiotics. In this study, a gentamicin-loaded Fe3O4/carbonated hydroxyapatite coating (Gent-MCHC) was fabricated according to the following steps: (i) deposition of Fe3O4/CaCO3 particles on Ti6Al4V substrates by electrophoretic deposition; (ii) conversions of MCHC from Fe3O4/CaCO3 coatings by chemical treatment; and (iii) formation of Gent-MCHC by loading gentamicin into MCHC. MCHC possessed mesoporous structure with a pore size of about 3.8 nm and magnetic property with the saturation magnetization strength of about 4.03 emu/g. Gent-MCHC had higher drug loading efficiency and drug release capacity, and superior biocompatibility and mitogenic activity than Ti6Al4V. Moreover, Gent-MCHC deterred bacterial adhesion and prevented biofilm formation. These results demonstrate that Gent-MCHC can be used as a local drug delivery system to prevent implant-associated infection in TJA surgery. (C) 2014 Elsevier B.V. All rights reserved.
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