Article
Polymer Science
Qianyu Lin, Chen Chuan Lim, Cally Owh, Joey Hui Min Wong, Valerie Ow, Belynn Sim, Yi Jian Boo, Michelle P. Y. Yew, Yi Hao Leow, Liangfeng Guo, Jason Y. C. Lim, Xian Jun Loh
Summary: Thermogels are a type of supramolecular hydrogels that undergo reversible sol-gel phase transitions and their unique properties depend on the hydrophilic-hydrophobic balance of the constituent polymers. Most thermogelling polymers use polyethylene glycol (PEG) as the hydrophilic segment, but this study introduces PEG-free amphiphilic polymers comprising only polyethylenimine (PEI) and polypropylene glycol (PPG) as the hydrophilic and hydrophobic segments, respectively. These polymers can self-assemble into micelles and supramolecular gel matrices. By modifying the PEI-PPG copolymers with benzyl groups, the resulting thermogel properties can be conveniently modulated. The hydrophobic-hydrophilic balance of the copolymers can also be adjusted to tune the critical gelation concentrations, gelation temperatures, and gel viscoelastic properties. In addition, the PEI segment exhibits pH-responsiveness, allowing for further alteration of thermogel viscoelasticity through pH adjustment. The convenience of postsynthetic functionalization, new material properties, and dual stimuli-responsiveness of these polycationic PEI-PPG thermogels can potentially offer a vast material design space for many unique applications.
Article
Chemistry, Physical
Lakshmi Priya Datta
Summary: Careful design can integrate chemical enrichment, stimuli responsiveness, and targeted delivery within compartmentalized models to enhance therapeutic efficacy.
Article
Polymer Science
Maria Varghese, Kaitlynn A. Sockett, Sara El-Arid, Jenny Korunes-Miller, Jean-Michel Guigner, Mark W. Grinsta
Summary: We synthesized diblock poly-amido-saccharides (PASs) using living anionic ring-opening polymerization. The resulting amphiphilic polymers self-assembled into nanoparticles in water, forming spherical structures and exhibiting no cytotoxicity.
Review
Chemistry, Multidisciplinary
Peng Zhang, Mingqian Li, Chunsheng Xiao, Xuesi Chen
Summary: This article summarizes the development of polypeptide-based drug delivery systems that respond to physiological stimuli such as pH, redox potential, glucose, and hypoxia. Polypeptides have the potential for controlled drug release.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Physical
Didier Gigmes, Thomas Trimaille
Summary: Amphiphilic copolymer micelles are key candidates in drug delivery, with PLA-based micelles and controlled radical polymerizations offering new opportunities for advanced drug delivery systems. Key properties such as stealth character, cell targeting and stimuli-responsiveness have been advanced in the past decade for PLA/vinyl polymer based nano-carriers.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Fangjun Liu, Dun Wang, Miao Zhang, Liwei Ma, Cui-Yun Yu, Hua Wei
Summary: The synthesis of PF-based theranostic amphiphilic copolymers with high drug loading efficiency and tumor microenvironment-specific responsiveness for enhanced cancer therapy has been rarely reported. In this study, enzyme-responsive theranostic amphiphilic bottlebrush copolymers were successfully prepared, showing high drug loading efficiency and tumor microenvironment-specific responsiveness. The study developed a universal strategy for the construction of multifunctional polymeric vehicles based on PF and degradable polypeptide, and emphasized the better stability of micelles endowed by the branched hydrophilic brushes.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Keli An, Xuqian Deng, Hongli Chi, Yuchao Zhang, Yan Li, Ming Cheng, Zhigang Ni, Zhi Yang, Chao Wang, Jinling Chen, Jianbo Bai, Chunyan Ran, Yong Wei, Juan Li, Penghui Zhang, Feng Xu, Weihong Tan
Summary: Proteolysis Targeting Chimeras (PROTACs) are a promising therapeutic modality for tackling undruggable and resistant issues in drug discovery. Researchers have developed a generalized caging strategy to synthesize stimuli-responsive PROTACs (sr-PROTACs) that can be activated and released in response to specific pathological cues and external triggers. These sr-PROTACs showed high solubility, long plasma exposure, and efficient protein degradation in tumor cells, making them potential candidates for personalized treatment and tissue engineering.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Akifumi Kawamura, Ayaka Harada, Shunsuke Ueno, Takashi Miyata
Summary: The dual stimuli-responsive gel particles prepared in this study can release drugs under weakly acidic and reducing conditions, providing a new approach for designing intracellular drug delivery carriers.
Article
Biochemistry & Molecular Biology
Dan Zhao, Dong Li, Fenli Quan, Yuhao Zhou, Zhen Zhang, Xuesi Chen, Chaoliang He
Summary: Thermoreversible hydrogels composed of PEG/P(EEO(2)LG) block copolymers exhibit rapid gel-to-sol transition rates within seconds, making them suitable for biomedical applications. These innovative hydrogels also show better biocompatibility and biodegradability compared to traditional hydrogels.
Article
Polymer Science
Puja Das Karmakar, Sagar Pal
Summary: In this study, a new pH-responsive amphiphilic graft copolymer was synthesized using ROP and RAFT techniques. The copolymer can efficiently self-assemble into micelles and is suitable for delivering drugs as a nanocarrier.
Article
Biochemistry & Molecular Biology
Daniel A. Paterson, Wye-Khay Fong, Sarah Hook, Allan B. Gamble
Summary: This study utilized a robust activator to synthesize BCPs, investigated self-assembly conditions and particle properties, and found that different solvents resulted in different structural morphologies. Triggering by hydrogen sulfide caused disruption or cross-linking of particles containing unsubstituted aryl azides, but was less sensitive for particles with substituents.
Article
Biochemistry & Molecular Biology
Iloh Son, Yujin Lee, Jinsu Baek, Miran Park, Daeho Han, Seung Kyu Min, Dongwon Lee, Byeong-Su Kim
Summary: A novel hydrophobic epoxide monomer with a pH-responsive cleavable linkage was successfully synthesized to form amphiphilic block copolymer micelles, demonstrating high loading capacity, excellent stability, tunable release efficiency, and high cell viability. Quantum mechanical calculations showed the monomer's higher hydrophobicity compared to other analogues, and cellular uptake and in vivo therapeutic efficacy confirmed the enhanced stability and pH-responsive degradation of the micelles. This study provides a new platform for versatile smart polymeric drug delivery systems with high loading efficiency and tailorable release profiles.
Article
Biochemistry & Molecular Biology
Jiali Zhai, Bo Fan, San H. Thang, Calum J. Drummond
Summary: The study synthesized a series of novel amphiphilic block copolymers (ABCs) using the RAFT technique, which could simultaneously stabilize a range of LLC MO nanoparticles and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. The functional ABCs have the potential to replace existing stabilizers and additives in forming the next generation of non-lamellar lipid nanoparticles, allowing for controlled drug release in tumor microenvironments with endogenous H2O2 and acidic pH conditions.
Article
Polymer Science
Semira Bener, Ewa Pavlova, Hynek Benes, Ondrej Sedlacek
Summary: Intelligent redox-responsive polymers have great potential in biomedical applications. This study successfully synthesized thioether-containing PAOx through a simple post-polymerization modification and demonstrated its oxidation-responsive behavior by self-assembling into micelles.
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biophysics
Na Re Ko, Jack Cheong, Anne Noronha, Christopher J. Wilds, Jung Kwon Oh
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Polymer Science
Min Soo Bae, Na Re Ko, Sang Jin Lee, Jung Bok Lee, Dong Nyoung Heo, Wook Byun, Byung-Joon Choi, Hoon Bong Jeon, Hee-Jae Jang, Ji-Yoon Ahn, Deok-Sang Hwang, Bock-Young Jung, Il Keun Kwon
MACROMOLECULAR RESEARCH
(2016)
Article
Polymer Science
Jung Ho Kim, Na Re Ko, Bock-Young Jung, Il Keun Kwon
MACROMOLECULAR RESEARCH
(2016)
Article
Materials Science, Textiles
Min Heo, Sang Jin Lee, Donghyun Lee, Dong Nyoung Heo, Jae Seo Lee, Yun Hee Youn, Si Eun Lee, Na Re Ko, Byung-Soo Kim, Ho-Nam Lim, Il Keun Kwon
FIBERS AND POLYMERS
(2017)
Article
Chemistry, Multidisciplinary
Eun Young Heo, Na Re Ko, Min Soo Bae, Sang Jin Lee, Byung-Joon Choi, Jung Ho Kim, Hyung Keun Kim, Su A. Park, Ii Keun Kwon
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2017)
Article
Chemistry, Physical
Na Re Ko, Md Nafiujjaman, Kondareddy Cherukula, Sang Ju Lee, Seoung-Jin Hong, Ho-Nam Lim, Chan Hum Park, In-Kyu Park, Yong-Kyu Lee, Il Keun Kwon
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2018)
Article
Chemistry, Multidisciplinary
N. R. Ko, M. Nafiujjaman, J. S. Lee, H. -N. Lim, Y. -K. Lee, I. K. Kwon
Article
Chemistry, Multidisciplinary
Na Re Ko, Sung Hwa Hong, Md Nafiujjaman, Seong Yeong An, Vishnu Revuri, Sang Ju Lee, Il Keun Kwon, Yong-Kyu Lee, Seung Jun Oh
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Na Re Ko, Se Young Van, Sung Hwa Hong, Seog-Young Kim, Miran Kim, Jae Seo Lee, Sang Ju Lee, Yong-kyu Lee, Il Keun Kwon, Seung Jun Oh
Article
Oncology
Arun Pandian Chandrasekaran, Naresh Poondla, Na Re Ko, Seung Jun Oh, Suresh Ramakrishna
Article
Biochemistry & Molecular Biology
Soumyadip Das, Arun Pandian Chandrasekaran, Ki-Sang Jo, Na Re Ko, Seung Jun Oh, Kye-Seong Kim, Suresh Ramakrishna
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Arun Pandian Chandrasekaran, Sang Hyeon Woo, Neha Sarodaya, Byung Ho Rhie, Apoorvi Tyagi, Soumyadip Das, Bharathi Suresh, Na Re Ko, Seung Jun Oh, Kye-Seong Kim, Suresh Ramakrishna
Summary: USP29 stabilizes Cdc25A protein expression in cancer cells, promoting cell proliferation and invasion, while knockdown of USP29 results in cell cycle arrest and reduced tumor size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Arun Pandian Chandrasekaran, Bharathi Suresh, Neha Sarodaya, Na-Re Ko, Seung-Jun Oh, Kye-Seong Kim, Suresh Ramakrishna
Summary: Among other cancers, colorectal carcinoma (CRC) is a leading cause of death worldwide. The study identified USP29 as highly expressed in CRC and may contribute to its progression. Depletion of USP29 in cancer cells reduced growth and tumor volume, suggesting it as a potential target for therapy.
Article
Biochemistry & Molecular Biology
Hyeon Jeong Kang, Nare Ko, Seung Jun Oh, Seong Yeong An, Yu-Shik Hwang, So Yeon Kim
Summary: Traumatic oral injuries often come with uncontrolled bleeding and inflammation. Injectable hydrogels, especially those based on fibrinogen, are promising for oral tissue regeneration in tissue engineering due to their simplicity in formulation and minimally invasive application technique.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Na Re Ko, Sang Ju Lee, Arun Pandian Chandrasekaran, Apoorvi Tyagi, Suresh Ramakrishna, Seog-Young Kim, Do Won Kim, Chan-Gi Pack, Seung Jun Oh
Summary: Chemotherapy is an effective treatment for cancer, but delivery of anticancer drugs is often hindered by hydrophobicity and low molecular weight. This study introduces biocompatible vitamicelles as promising vehicles for anticancer drugs, with high stability, biodegradability, and enhanced anticancer effect compared to free drugs. These vitamicelles offer a potential strategy to overcome existing challenges in drug delivery and enhance the utility of current chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
