Article
Polymer Science
J. F. A. Valente, P. Pereira, A. Sousa, J. A. Queiroz, F. Sousa
Summary: Gene therapy involves introducing functional genes into patients to correct specific mutations. In this study, different plasmids were complexed with chitosan (CH) or polyethyleneimine (PEI) polymers to evaluate their effectiveness in gene delivery systems. Chitosan polyplexes showed higher transfection efficiency and P53 protein expression compared to PEI polyplexes.
Article
Biochemistry & Molecular Biology
Renata Mello Giona, Leticia Vitorazi, Watson Loh
Summary: The interaction of DNA with different block copolymers, (PTEA)-b-(PAm) and (PTEA)-b-(PEO), was studied. The copolymers showed endothermic interaction with DNA and had different hydrodynamic diameters for the formed polyplexes. The size and charge of the polyplexes were affected by the order of addition.
Article
Biochemistry & Molecular Biology
Irina Alekseevna Nedorubova, Tatiana Borisovna Bukharova, Viktoria Olegovna Mokrousova, Maria Aleksandrovna Khvorostina, Andrey Vyacheslavovich Vasilyev, Andrey Anatolevich Nedorubov, Timofei Evgenevich Grigoriev, Yuriy Dmitrievich Zagoskin, Sergei Nicolaevich Chvalun, Sergey Ivanovich Kutsev, Dmitry Vadimovich Goldshtein
Summary: Gene-activated matrices based on polylactide granules impregnated with BMP2 polyplexes and included in chitosan hydrogel or PRP-based fibrin hydrogel were developed. These matrices showed high biocompatibility, promoted osteogenesis and new bone formation, and have potential applications in bone regeneration, particularly the PLA/PRP matrices.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valerij Y. Grinberg, Tatiana Burova, Natalia Grinberg, Alexander S. Dubovik, Vladimir E. Tikhonov, Alexander P. Moskalets, Victor N. Orlov, Irina G. Plashchina, Alexei R. Khokhlov
Summary: The energetics of chitosan (CS) polyplexes and the conformational stability of bound DNA were analyzed at pH 5.0 using ITC and HS-DSC, respectively. The CS-DNA binding mechanism was found to involve cooperative attachment of interacting CS ligands to the DNA matrix, as shown by the well-fitted McGhee-von Hippel model. The melting thermograms of polyplexes revealed the transformation of different conformational forms of bound DNA depending on the CS/DNA weight ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Asya Petkova, Ilona Kubajewska, Alexandra Vaideanu, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Gene delivery to the cerebral cortex can be achieved via intranasal administration of hyaluronidase-coated polyplexes (GCPH).
Article
Pharmacology & Pharmacy
Dimitrios Selianitis, Hector Katifelis, Maria Gazouli, Stergios Pispas
Summary: We synthesized hyperbranched polyelectrolyte copolymers, P(OEGMA-co-DIPAEMA), by reversible addition fragmentation chain transfer (RAFT) polymerization, and studied their complexation behavior with short-linear DNA molecules. The hyperbranched copolymers formed polyplexes with DNA, with nanoscale dimensions. The properties of the polyplexes were explored using various physicochemical methods, and the stability of polyplexes in the presence of serum proteins was found to be excellent. The cytotoxicity of the copolymers was evaluated and found to be sufficiently non-toxic. Based on our results, these copolymers could be useful candidates for gene delivery and related biomedical applications.
Article
Engineering, Biomedical
Narayan Ture, Drashti Desai, Pravin Shende
Summary: The study aimed to develop polyplexes for co-delivery of plasmid DNA with retinoic acid against colorectal cancer cell line, showing higher potential in inducing apoptosis and cell inhibition.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dalila Miele, Xin Xia, Laura Catenacci, Milena Sorrenti, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, John J. Rossi, Maria Cristina Bonferoni
Summary: Oligonucleotide therapeutics such as miRNAs and siRNAs are developed to modulate gene expression, but face issues of instability and easy degradation. Viral and non-viral vectors are used for efficient delivery, with non-viral vectors like polymeric nanocarriers providing safer and more effective means of delivery.
Article
Biochemistry & Molecular Biology
Lucas Del Coli B. Araujo, Henrique K. de Matos, Debora P. Facchi, Debora A. de Almeida, Bruna M. G. Goncalves, Johny P. Monteiro, Alessandro F. Martins, Elton G. Bonafe
Summary: In this study, a natural carbohydrate-based CS/Pec hydrogel adsorbent was developed for efficient removal of Pb(II) from aqueous solutions, showing high adsorption capacities. However, the hydrogel adsorbent exhibited limited potential for reuse, indicating the need for further research to improve its reusability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Zhen Zhang, Nasha Qiu, Shuling Wu, Xin Liu, Zhuxian Zhou, Jianbin Tang, Yanpeng Liu, Ruhong Zhou, Youqing Shen
Summary: The stability and endocytosis pathway of cationic polymer complexes determine their transfection dose-dependence. Polyplexes with optimal hydrophobicity can remain integrated at low concentrations and enter cells via macropinocytosis, achieving dose-independent DNA transfection.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Simone Berger, Ana Krhac Levacic, Elisa Hoerterer, Ulrich Wilk, Teoman Benli-Hoppe, Yanfang Wang, Ozgur Ozturk, Jie Luo, Ernst Wagner
Summary: The study optimized lipophilic oligoaminoamides (OAAs) based on succinoyl tetraethylene pentamine (Stp) for pDNA delivery, finding that OAAs with fatty acid chain lengths around C6 to C10 exhibited higher gene transfer efficiency. Promising compounds showed moderate in vivo efficiency, indicating the need for further refinement.
Article
Polymer Science
Min-Kyung Chae, Nam-Kyung Lee, Youngkyun Jung, Albert Johner
Summary: Charged polymers with random charge sequences form pearl-necklace structures, with dynamics of pearls controlled by nucleation/dissolution processes. Most sequences have a stable number of large pearls, while a few exhibit fast-switching behavior. Similar shape fluctuations are observed in intrinsically disordered protein (IDP) sequences.
Review
Pharmacology & Pharmacy
Maria Karayianni, Theodore Sentoukas, Athanasios Skandalis, Natassa Pippa, Stergios Pispas
Summary: This review summarizes the recent developments in chitosan-based nanoparticles as nucleic acid delivery vehicles and gene therapy vectors, with special attention given to the technological aspects of chitosan complexes for nucleic acid delivery.
Article
Cell Biology
Shani Attias Cohen, Orit Bar-Am, Claudia Fuoco, Galit Saar, Cesare Gargioli, Dror Seliktar
Summary: This study further investigated the delivery strategy of using PF microspheres as a carrier for AON therapy in DMD. The results showed that the use of PF microspheres as a carrier improved the efficacy of AON therapy, restoring Dystrophin expression in mdx mice muscles and improving tissue histopathology. Intra-femoral injection of the microspheres demonstrated better results compared to intramuscular injection.
CELL DEATH & DISEASE
(2022)
Article
Polymer Science
Teoman Benli-Hoppe, Surhan Gol Ozturk, Ozgur Ozturk, Simone Berger, Ernst Wagner, Mina Yazdi
Summary: This study aimed to develop Tf receptor (TfR) targeted small interfering RNA (siRNA) polyplexes composed of synthetic, monodisperse, and sequence-defined subunits for efficient gene silencing in tumors. The use of an optimized cationizable lipo-oligoaminoamide (lipo-OAA) for siRNA core polyplex formation and retro-enantio peptide (reTfR) for targeting resulted in improved gene silencing in TfR-expressing cells. Additionally, plasmid DNA (pDNA) polyplexes were successfully used for receptor-mediated gene delivery in TfR-rich cells.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Serena De Santis, Edoardo Rossi, Marco Sebastiani, Simona Sennato, Edoardo Bemporad, Monica Orsini
Summary: Surface free energy (SFE) of titanium surfaces plays a significant role in tissue engineering, affecting the effectiveness and long-term stability of active coatings and functionalization as well as the establishment of strong bonds to newly growing bone. This study used a high-resolution non-destructive elastic contacting nanoindentation method to investigate the SFE of micro- and nano-structured titanium surfaces, both immediately after preparation and after exposure to air. The effectiveness of different surface treatments in enhancing SFE was evaluated. The study observed a time-dependent decay of SFE within a few hours, with kinetics related to sample preparation. The fast, non-destructive method allowed for accurate measurement of SFE in very hydrophilic conditions, allowing for reliable comparison between surfaces with different properties.
Article
Biochemistry & Molecular Biology
Luca Raganato, Alessandra Del Giudice, Anita Ceccucci, Fabio Sciubba, Stefano Casciardi, Simona Sennato, Anita Scipioni, Giancarlo Masci
Summary: This study reports the preparation and characterization of a novel peptide-polysaccharide conjugate that can self-assemble into nanowire structures. The conjugate was synthesized through solid phase click-chemistry and possessed a block-like architecture. The self-assembly of the conjugate was driven by strong hydrogen bonds and hydrophobic interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Angela Capocefalo, Thomas Bizien, Simona Sennato, Neda Ghofraniha, Federico Bordi, Francesco Brasili
Summary: This study presents a thorough investigation of a hybrid nanomaterial based on the protein-mediated aggregation of gold nanoparticles. The main factors that determine the assembly process and their strong correlation with the optical properties of the assemblies were established. The calibration curves obtained based on the extinction spectra indicate the notable flexibility of this nanomaterial, enabling the selection of different working ranges with high sensitivity.
Article
Chemistry, Physical
Laura Chronopoulou, Francesca Falasca, Federica Di Fonzo, Ombretta Turriziani, Cleofe Palocci
Summary: Gene delivery is essential for gene therapies, and targeting viral replication with short interfering RNAs (siRNAs) is a novel strategy for treating HIV-1 infection. In this study, chitosan particles containing siRNA tat/rev were effectively internalized by cells, leading to a significant reduction in HIV replication.
Article
Archaeology
Lorenzo Nigro, Francesco Mura, Maria Pamela Toti, Angela Cirigliano, Teresa Rinaldi
Summary: This passage describes the discovery of the 'Motya Charioteer' marble statue and its microbial deterioration. The study found that bacterial strains capable of dissolving marble and causing degradation were mainly present in the damaged areas of the statue. Among them, a common component of human skin flora, Staphylococcus haemolyticus, demonstrated fast calcium carbonate dissolution, which was previously unreported for this species. Additionally, two bacterial strains suitable for bioconsolidation intervention on the sculpture were identified.
JOURNAL OF CULTURAL HERITAGE
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Orekhova, Cleofe Palocci, Laura Chronopoulou, Giulia De Angelis, Camilla Badiali, Valerio Petruccelli, Simone D'Angeli, Gabriella Pasqua, Giovanna Simonetti
Summary: In this study, PLGA nanoparticles loaded with Coumarin 6 and pterostilbene were tested for their antifungal activity and uptake efficiency against Aspergillus brasiliensis biofilm. The results showed that PLGA-PTB-NPs had a significant inhibitory effect on biofilm formation and reduced mortality in infected larvae. The PLGA-NPs system demonstrated the ability to improve the bioavailability of pterostilbene in Aspergillus section Nigri biofilm.
Article
Chemistry, Multidisciplinary
Irene Antignano, Francesca D'Acunzo, Davide Arena, Stefano Casciardi, Alessandra Del Giudice, Francesca Gentile, Maria Pelosi, Giancarlo Masci, Patrizia Gentili
Summary: In this study, we compared nanoaggregation driven by pH-induced micellization (PIM) and by the standard solvent displacement (SD) method on pH-, light-, and thermosensitive block copolymers. The results showed that pH-based nanoaggregation provides advantages in obtaining compact micelles with well-defined responses to external stimuli.
Article
Chemistry, Physical
Sara Cerra, Tommaso A. Salamone, Andrea Bearzotti, Farid Hajareh Haghighi, Martina Mercurio, Martina Marsotto, Chiara Battocchio, Raoul Fioravanti, Marco Diociaiuti, Ilaria Fratoddi
Summary: This study describes the preparation of three different functionalized palladium nanoparticles (PdNPs) systems for room temperature BTX sensing and their morphostructural characterization. The PdNPs are prepared using a wet chemical reduction method in the presence of bifunctional organic thiols as stabilizing agents. The PdNPs systems show promising results for gas sensing applications, particularly in the detection of benzene, toluene, and p-xylene.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2023)
Article
Chemistry, Physical
Elvira Maria Bauer, Gabriele Bogliardi, Cosimo Ricci, Daniele Cecchetti, Tilde De Caro, Simona Sennato, Alessandro Nucara, Marilena Carbone
Summary: Extrinsic chemiluminescence is an efficient tool for determining pesticides and fungicides without intrinsic fluorescent signal. In this study, APTMS@ZnO was synthesized and tested as an extrinsic probe for the fungicide penconazole. Different synthetic routes were explored to ensure a green synthesis pathway and a good signal variation for penconazole concentration. The synthesized samples were characterized using various techniques. The chemiluminescence tests showed a good linear response and a low detection limit for penconazole.
Article
Chemistry, Physical
Laura Chronopoulou, Roya Binaymotlagh, Sara Cerra, Farid Hajareh Haghighi, Enea Gino Di Domenico, Francesca Sivori, Ilaria Fratoddi, Silvano Mignardi, Cleofe Palocci
Summary: In this study, a new composite material was developed by impregnating self-assembling Fmoc-Phe3 peptide hydrogels with in situ prepared silver nanoparticles (AgNPs). Different methodologies for preparing AgNPs were compared. The obtained composites were characterized for their hydrodynamic, structural, and morphological properties, and the antibacterial properties against S. aureus were tested. The results showed that the hydrogel composites containing AgNPs could potentially be used as biomaterials for treating S. aureus-related infections.
Article
Plant Sciences
Giulia De Angelis, Camilla Badiali, Laura Chronopoulou, Cleofe Palocci, Gabriella Pasqua
Summary: Most previous studies on endocytosis in plant cells have focused on clathrin-dependent pathways, leaving limited evidence on clathrin-independent pathways. This study investigated the role of dynamin a, a key protein in both types of endocytic processes, in the uptake of PLGA nanoparticles (NPs). The results showed that NPs can enter plant cells and roots through a dynamin-like-independent endocytic pathway.
Review
Engineering, Biomedical
Roya Binaymotlagh, Laura Chronopoulou, Cleofe Palocci
Summary: Tissue and organ regeneration is a frontier research in the biomedical field, and the lack of ideal scaffold materials is a major problem. Peptide hydrogels have gained increasing attention due to their biocompatibility, biodegradability, good mechanical stability, and tissue-like elasticity, making them excellent candidates for 3D scaffold materials. This review describes the main features of peptide hydrogels as 3D scaffolds, focusing on mechanical properties, biodegradability, and bioactivity, and discusses recent applications in tissue engineering.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Polymer Science
Roya Binaymotlagh, Alessandra Del Giudice, Silvano Mignardi, Francesco Amato, Andrea Giacomo Marrani, Francesca Sivori, Ilaria Cavallo, Enea Gino Di Domenico, Cleofe Palocci, Laura Chronopoulou
Summary: This study investigated the synthesis of peptide-based hydrogel composites containing photo-generated silver nanoparticles (AgNPs) and the effects of honey on their properties. The results showed that honey increased the swelling ability and mechanical stability of the hydrogel. Additionally, the presence of honey enhanced the antibacterial activity of AgNPs in the hydrogel.
Review
Chemistry, Physical
Roya Binaymotlagh, Laura Chronopoulou, Farid Hajareh Haghighi, Ilaria Fratoddi, Cleofe Palocci
Summary: Peptide-based hydrogels have gained increasing attention due to their potential applications in various biomedical fields, such as anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering. Additionally, their biosensing applications, especially in cancer detection, are also of great interest.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)