Article
Pharmacology & Pharmacy
Iqra Rahat, Md. Rizwanullah, Sadaf Jamal Gilani, May Nasser Bin-Jummah, Syed Sarim Imam, Chandra Kala, Mohammad Asif, Sultan Alshehri, Satish K. Sharma
Summary: Chitosan modified solid lipid nanoparticles were developed to enhance the oral bioavailability of thymoquinone, showing optimized nanoparticles with good in vitro and ex vivo performance, strong mucoadhesive properties, and controlled drug release. The results indicated significantly improved oral bioavailability compared to thymoquinone suspension.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sonia Trombino, Rocco Malivindi, Giuseppe Barbarossa, Roberta Sole, Federica Curcio, Roberta Cassano
Summary: Classical melanoma therapy often has side effects, affecting the efficacy and patient compliance. Drug delivery systems, such as solid lipid nanoparticles (SLNs), can improve drug stability, release kinetics, and enhance therapy safety and efficacy. In this study, SLNs were prepared using hydroquinone esterified with stearic acid and characterized using FT-IR and H-1-NMR. The efficacy of SLNs on COLO-38 human melanoma cells were evaluated, and their potential effects on apoptotic mechanisms were analyzed. Safety tests, cytotoxicity evaluation, and antioxidant and anti-inflammatory activities were also conducted.
Article
Pharmacology & Pharmacy
Anroop B. Nair, Jigar Shah, Bandar E. Al-Dhubiab, Shery Jacob, Snehal S. Patel, Katharigatta N. Venugopala, Mohamed A. Morsy, Sumeet Gupta, Mahesh Attimarad, Nagaraja Sreeharsha, Pottathil Shinu
Summary: The study demonstrated that optimized solid lipid nanoparticles (SLNs) loaded with clarithromycin can improve ocular drug permeation and enhance the therapeutic potential of the drug, providing a promising drug delivery approach for treating endophthalmitis.
Article
Chemistry, Multidisciplinary
Mohammad Jammed Ansari, Mahfoozur Rahman, Khalid S. Alharbi, Waleed M. Altowayan, Ahmed Mahmoud Abdelhaleem Ali, Waleed H. Almalki, Md Abul Barkat, Tanuja Singh, Shehla Nasar, Md Habban Akhter, Sarwar Beg, Hani Choudhry
Summary: The present work demonstrates the development and characterization of liquid crystalline nanoparticles for the treatment of hepatocellular carcinoma. The optimized formulation (HP5) showed good stability, high bioavailability, and improved anticancer activity, making it a promising treatment option for liver cancer.
Article
Chemistry, Medicinal
Ibrahim A. Aljuffali, Md. Khalid Anwer, Mohammed Muqtader Ahmed, Ahmed Alalaiwe, Mohammed F. Aldawsari, Farhat Fatima, Shahid Jamil
Summary: In this study, the toxic effects of gefitinib-loaded solid lipid nanoparticles on human breast cancer cells were investigated. The optimized formulation showed sustained drug release and enhanced activity against the cancer cells, suggesting it as a promising therapeutic alternative for breast cancer.
Article
Pharmacology & Pharmacy
Azadeh Emami, Hossein Ghafouri, Reyhaneh Sariri
Summary: This study developed and optimized a PD-loaded SLN formulation and evaluated its efficacy in breast cancer cell lines. Apoptosis was confirmed as the mechanism of cell death, and the PD-loaded SLN showed significant increase in apoptosis. In vivo studies on mice also supported this effect. PD-loaded SLN may be a promising breast cancer treatment without recognizable side effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiaoshu Qu, Dan Shi, Yu Fu, Dongxue Chu, Yanyan Yang, Yan Liu
Summary: The study demonstrated enhanced antitumor activity of POMs in nano-encapsulated forms, with structural characterization and in vitro activity testing conducted on the POMs. Results showed the stability and increased activity of POMs when encapsulated in solid lipid nanoparticles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Thermodynamics
Guohua Ren, Ying Zhao
Summary: The preparation of Calcipotriol by solid lipid nanoparticles and its stability in a low-temperature environment was demonstrated. The study showed that CPT-SLNS is more effective in treating psoriasis than conventional ointments.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Biotechnology & Applied Microbiology
Prathiba Gnanasekaran, Anitha Roy, Nagabhishek Sirpu Natesh, Varshini Raman, Priyanka Ganapathy, Madan Kumar Arumugam
Summary: In this study, nano thymoquinone (nTQ) was synthesized and characterized. The results showed that biologically synthesized nTQ exhibited higher activity in removing potential microbial pathogens and increasing cancer cell death compared to chemically synthesized nTQ. These findings may support the use of biosynthesis method of nTQ over the chemosynthesis method.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Review
Biotechnology & Applied Microbiology
Maja van Hees, Sofie Slott, Anders Hojgaard Hansen, Heon Seok Kim, Hanlee P. Ji, Kira Astakhova
Summary: This article introduces new approaches for improving cellular uptake and endosomal escape of CRISPR-Cas9, with a focus on non-viral carriers. It also discusses the use of peptide and nanoparticle-based systems as platforms for in vivo CRISPR-Cas9 delivery.
Article
Pharmacology & Pharmacy
Federica De Gaetano, Consuelo Celesti, Giuseppe Paladini, Valentina Venuti, Maria Chiara Cristiano, Donatella Paolino, Daniela Iannazzo, Vincenza Strano, Anna M. Gueli, Silvana Tommasini, Cinzia Anna Ventura, Rosanna Stancanelli
Summary: In recent years, the focus of scientific research has been on bioactive compounds due to their unique properties and low toxicity. However, these compounds have low solubility, chemical stability, and bioavailability. Solid lipid nanoparticles (SLNs) have emerged as potential drug delivery systems to overcome these limitations. This study successfully prepared MRN-loaded SLNs using different lipids and investigated their properties. The MRN-SLNs showed spherical and non-aggregated morphology with high encapsulation efficiency. The release studies demonstrated sustained release of MRN over 10 days. Furthermore, ex vivo permeation studies confirmed the ability of SLNs to enhance the penetration of MRN.
Article
Pharmacology & Pharmacy
Monica Cerqueira, Efres Belmonte-Reche, Juan Gallo, Fatima Baltazar, Manuel Banobre-Lopez
Summary: Cancer is a leading cause of death worldwide, with a projected increase in global cancer incidence in the next two decades. Nanomedicine formulations have the potential to improve the effectiveness of conventional cancer therapies. However, the targeting efficiency of advanced nanomedicines in oncology is currently one of the major limitations, highlighting the need for more efficient nanoformulation designs.
Article
Polymer Science
Syed Sarim Imam, Sadaf Jamal Gilani, May Nasser Bin Jumah, Md Rizwanullah, Ameeduzzafar Zafar, Mohammed Muqtader Ahmed, Sultan Alshehri
Summary: This study developed THQ-loaded lipid-polymer hybrid nanoparticles (THQ-LPHNPs) based on chitosan, which showed enhanced oral bioavailability for THQ. The optimized THQ-LPHNPs exhibited ideal properties for oral administration, including a small particle size, high entrapment efficiency, and good stability. They also demonstrated excellent mucin binding efficiency and enhanced anti-breast cancer activity. Furthermore, the optimized THQ-LPHNPs showed significantly increased permeation and bioavailability compared to conventional THQ suspension.
Article
Chemistry, Multidisciplinary
Mohammad Rashedul Hasan, Bart-Jan Niebuur, Martin Siebrecht, Bjorn Kuttich, Ralf Schweins, Asaph Widmer-Cooper, Tobias Kraus
Summary: Solvent engineering provides a powerful method to control the colloidal stability of nanoparticles. In this study, the molecular structure of ligand shells on gold nanoparticles was found to affect their stability in solvent mixtures. The agglomeration temperature of the nanoparticles depended on the solvent composition and exhibited different trends in different solvent mixtures. Molecular dynamics simulations revealed that temperature-dependent ligand order played a dominant role in the agglomeration process, while the solvent composition near the ligands significantly influenced the ligand shell ordering. The results highlight the importance of ligand-solvent and solvent-solvent interactions in determining the colloidal stability of nanoparticles in solvent mixtures.
Review
Chemistry, Multidisciplinary
Chuan-He Tang, Huan-Le Chen, Jin-Ru Dong
Summary: Although SLNs and NLCs have been used as drug delivery systems, they have been less investigated as food-grade nanovehicles for nutraceuticals. This review comprehensively explores the development and utilization of food-grade SLNs and NLCs as nanosized delivery systems. It discusses issues such as incorporation and release of bioactives, oxidative stability, lipid digestion and absorption, intestinal transport, and encapsulation and delivery of nutraceuticals. The review also highlights the performance of these nanoparticles in improving stability, bioavailability, and bioactivities of curcuminoids.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, F. J. Ahmad
Summary: The use of gold nanoparticles (AuNP) in food safety is crucial due to their unique properties. Nanosensors are emerging as key technologies to detect various contaminants in food industries. Research is ongoing in the food industry to explore the applications of AuNP-based nanosensors and nanobiosensors.
FOOD ANALYTICAL METHODS
(2022)
Article
Engineering, Electrical & Electronic
Shafaque Rahman, Farhan Ahmad, Jyoti Bansal, Rana Tabassum, A. K. Hafiz
Summary: This study reports on the fabrication and characterization of tricomposite nanostructures of silicon-doped titanium dioxide and multiwalled carbon nanotubes. The fabricated nanostructures possess typical nanoflower shape and show an increase in bandgap with increasing silicon concentration. The tricomposite nanostructures exhibit superior performance in specific capacitance, quantum efficiency, responsivity, and detectivity compared to reported data.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Chemistry, Analytical
Nazeer Hasan, Mohammad Imran, Dhara Jain, Athar Shamim, Sarwar Beg, Prashant Kesharwani, Gaurav Jain, Farhan J. Ahmad
Summary: The paper describes the development and validation of a simple and reliable HPLC method for simultaneous estimation of 5-FU and CBD. The method showed good linearity, precision, specificity, and robustness. It could be effectively used for quantification of these drugs in various in vitro and in vivo studies.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, Sauban Ahmed Khan, Shaheen Shabbir, Md Umar, Sradhanjali Mohapatra, Tahir Khuroo, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Zeenat Iqbal, Mohd Aamir Mirza
Summary: 4D printing, an advanced version of 3D printing, combines smart materials and the fourth dimension of time. It is widely used in sectors such as healthcare, with applications including self-adjusting stents, artificial muscles, and drug delivery. Further research is needed to explore more responsive materials and technologies.
Article
Pharmacology & Pharmacy
Sradhanjali Mohapatra, Mohd. Aamir Mirza, Sayeed Ahmad, Uzma Farooq, Mohammad Javed Ansari, Kanchan Kohli, Zeenat Iqbal
Summary: Black cohosh is a popular herb used to alleviate menopausal symptoms. This study aimed to develop an ethosomal gel containing a triterpene enriched fraction from black cohosh and evaluate its efficacy through transdermal application. By using a quality by design approach, the optimized ethosomal gel showed better performance compared to the conventional gel. Additional animal studies are needed to further validate these results.
Review
Infectious Diseases
Athar Shamim, Asgar Ali, Zeenat Iqbal, Mohd Aamir Mirza, Mohd Aqil, S. M. Kawish, Ayesha Siddiqui, Vijay Kumar, Punnoth Poonkuzhi Naseef, Abdulkhaliq Ali F. Alshadidi, Mohamed Saheer Kuruniyan
Summary: Studies on biofilm-related infections are gaining prominence due to their involvement in most clinical infections and serious threat to global public health. Biofilm is a natural form of bacterial growth that is ubiquitous in ecological niches and acts as a survival mechanism for both pathogenic and non-pathogenic microorganisms. Quorum sensing plays a crucial role in biofilm development. Biofilm formation leads to increased resistance to antibiotics and antimicrobial agents. Natural plant-derived phytomedicines, including various compounds such as flavonoids, terpenoids, lectins, alkaloids, polypeptides, polyacetylenes, phenolics, and essential oils, are being explored as alternative and safe therapies with minimal side effects for controlling biofilm production and growth.
Article
Chemistry, Multidisciplinary
Manvi Singh, Abdul Rehman, Nazia Hassan, Abdul Anfey Faheem, Ayan Das, Mohammad Akhlaquer Rahman, Mohammad Javed Ansari, Nilima Sharma, Mridu Dudeja, Mohd Aqil, Mohd Aamir Mirza, Zeenat Iqbal
Summary: A ciprofloxacin-loaded water-in-oil nanoemulsion (CPX-NE) was prepared and evaluated for its antimicrobial effect against oral biofilms produced by Enterococcus faecalis. The CPX-NE showed optimal rheological parameters, similar pH to the oral cavity, uniform spherical nanodroplets with narrow size distribution and stable charge. In vitro drug release demonstrated sustained release for 48 hours. CPX-NE exhibited significant inhibitory and eradication effect compared to the plain drug solution. Therefore, CPX-NE has effective antibiofilm activity against E. faecalis and may be useful in the prevention and treatment of dental caries.
Article
Chemistry, Multidisciplinary
Nazia Hassan, Uzma Farooq, Ayan Kumar Das, Kalicharan Sharma, Mohd. Aamir Mirza, Suhail Fatima, Omana Singh, Mohammad Javed Ansari, Asgar Ali, Zeenat Iqbal
Summary: This study aims to develop a tailored vaginal drug delivery system for the treatment of drug-resistant Candida vulvovaginitis involving multispecies of Candida and epithelium-bound biofilm. A luliconazole-loaded nanostructured lipid carrier-based transvaginal gel was fabricated to combat Candida albicans biofilm and alleviate the disease. In silico tools were used to assess the interaction and binding affinity of luliconazole against C. albicans proteins and biofilm. The optimized nanogel formulation showed suitable characteristics, such as small particle size, non-Newtonian flow behavior, and high drug release and permeation rates.
Review
Biochemistry & Molecular Biology
Mohammad Sameer Khan, Sradhanjali Mohapatra, Vaibhav Gupta, Ahsan Ali, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kurunian, Abdulkhaliq Ali F. Alshadidi, Md Shamsher Alam, Mohd. Aamir Mirza, Zeenat Iqbal
Summary: In recent years, the pharmaceutical and biomedical fields have achieved remarkable advancements in medicine, diagnostics, and drug delivery, with nanotechnology-based tools playing a major role. The use of nanotechnology in drug delivery has led to the development of innovative strategies and materials to improve patient compliance. Lipid-based nanocarriers offer a potential solution to overcome biological barriers, such as the skin and blood-brain barrier, by facilitating drug penetration and enhancing their effectiveness.
Article
Polymer Science
Rahmuddin Khan, Mohd. Aamir Mirza, Mohd Aqil, Thomson Santosh Alex, Nafis Raj, Nikhat Manzoor, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Zeenat Iqbal
Summary: This study developed a nanotherapeutic consisting of bioactives to improve the treatment outcomes of psoriasis.
Article
Chemistry, Multidisciplinary
Manvi Singh, Abdul Rehman, Nazia Hassan, Abdul Anfey Faheem, Ayan Das, MohammadAkhlaquer Rahman, Mohammad Javed Ansari, Nilima Sharma, Mridu Dudeja, Mohd Aqil, Mohd. Aamir Mirza, Zeenat Iqbal
Summary: A ciprofloxacin-loaded nanoemulsion was prepared and found to have effective antimicrobial activity against oral biofilms produced by Enterococcus faecalis, suggesting potential applications in the prevention and treatment of dental caries.
Review
Clinical Neurology
Namish Manchanda, Akanksha Aggarwal, Sonal Setya, Sushama Talegaonkar
Summary: Alzheimer's disease is a global health crisis with limited therapeutic options. Digital therapeutics, a novel therapy driven by internet and software, provides evidence-based interventions and tools for managing and treating neurological abnormalities and chronic diseases. It shows potential in improving memory, cognition, and functional abilities in Alzheimer's disease.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Rahmuddin Khan, Pooja Jain, Foziyah Zakir, Mohd Aqil, Sameer Alshehri, Mohd Aamir Mirza, Zeenat Iqbal
Summary: This study reaffirms the potential of using peat as a source of FA to significantly enhance drug solubility and bioavailability, leading to a reduction in the duration of epileptic seizures.
SCIENTIA PHARMACEUTICA
(2022)
Review
Chemistry, Multidisciplinary
Pooja Jain, Uzma Farooq, Nazia Hassan, Mohammed Albratty, Md. Shamsher Alam, Hafiz A. Makeen, Mohd. Aamir Mirza, Zeenat Iqbal
Summary: Advancements in nanotechnology have had a significant impact on oral health, particularly in dental nanorobotics. The complex nature of dental diseases requires customized treatments, which can be developed through various nanotechnology armamentariums. Researchers have also explored the use of nanomaterials for controlled drug delivery in dental infections. However, the cost and scaling issues limit the commercialization of nanotechnology.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
