期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 104, 期 -, 页码 245-253出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2012.11.031
关键词
Nanoparticles; Colon cancer; Drug delivery; Amorphous chitin; Paclitaxel; Ionic cross-linking
资金
- Department of Science and Technology (DST) [SR/NM/NS-99/2009]
- Council of Scientific and Industrial Research (CSIR), India (SRF) [9/963 (0005) 2K10378-EMR-I]
Chitin and its derivatives have been widely used in drug delivery applications due to its biocompatible, biodegradable and non-toxic nature. In this study, we have developed amorphous chitin nanoparticles (150 +/- 50 nm) and evaluated its potential as a drug delivery system. Paclitaxel (PTX), a major chemotherapeutic agent was loaded into amorphous chitin nanoparticles (AC NPs) through ionic cross-linking reaction using TPP. The prepared PTX loaded AC NPs had an average diameter of 200 +/- 50 nm. Physicochemical characterization of the prepared nanoparticles was carried out. These nanoparticles were proven to be hemocompatible and in vitro drug release studies showed a sustained release of PTX. Cellular internalization of the NPs was confirmed by fluorescent microscopy as well as by flow cytometry. Anticancer activity studies proved the toxicity of PTX-AC NPs toward colon cancer cells. These preliminary results indicate the potential of PTX-AC NPs in colon cancer drug delivery. (C) 2012 Elsevier B.V. All rights reserved.
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