Article
Biochemistry & Molecular Biology
Manuela Santonocito, Cristina Zappulla, Santa Viola, Luca Rosario La Rosa, Elena Solfato, Ilenia Abbate, Valeria Tarallo, Ivana Apicella, Chiara Bianca Maria Platania, Grazia Maugeri, Velia D'Agata, Claudio Bucolo, Sandro De Falco, Maria Grazia Mazzone, Francesco Giuliano
Summary: The study demonstrates that NaMESys-SOR eye drops can effectively deliver sorafenib to the retina and reduce proinflammatory and pro-angiogenic mediators in various animal models, showing potential for the treatment of proliferative retinopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Pradip Nirbhavane, Laxmi Moksha, Gajanand Sharma, Thirumurthy Velpandian, Bhupinder Singh, O. P. Katare
Summary: This study evaluated a novel nano-lipoidal eye drop formulation of triamcinolone acetonide (TA) for the topical treatment of uveitis. The developed triamcinolone acetonide-loaded nanostructured lipid carriers (cTA-NLC) showed sustained release and enhanced efficacy in vitro. In vivo efficacy was tested on Wistar rats and a pharmacokinetic study was conducted in rabbits. The results demonstrated that the cTA-NLC formulation effectively managed uveitis with minimal signs of inflammation.
Article
Pharmacology & Pharmacy
Maria Lina Formica, Hamoudi Ghassan Awde Alfonso, Alejandro Javier Paredes, Maria Elisa Melian, Nahuel Matias Camacho, Ricardo Faccio, Luis Ignacio Tartara, Santiago Daniel Palma
Summary: Triamcinolone acetonide nanocrystals (TA-NC) were obtained to improve ocular corticosteroid therapy. Self-dispersible TA-NC with a average particle size of 257 +/- 30 nm and a zeta potential of -25 +/- 3 mV were prepared by bead milling technique and spray-drying. In vivo evaluation in an ocular model showed that self-dispersible TA-NC alleviated the inflammatory response in rabbit eyes. Self-dispersible TA-NC are a promising approach for ocular disorders.
Article
Pharmacology & Pharmacy
Girdhari Roy, Prashant Garg, Venkata Vamsi Krishna Venuganti
Summary: The microneedle scleral patch (MSP) demonstrates effective drug delivery to the posterior segment of the eye, showing higher safety scores and efficacy compared to traditional intravitreal injections and other methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Instruments & Instrumentation
Rakhee Kapadia, Kinjal Parikh, Mahendra Jain, Krutika Sawant
Summary: The study successfully developed a novel lipid-based carrier-emulsome for non-invasive delivery to the posterior segment of the eye, demonstrating promising performance in transcorneal permeation and ocular safety through a series of characterizations and studies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Abhinav Thareja, Helen Hughes, Carmen Alvarez-Lorenzo, Jenni J. Hakkarainen, Zubair Ahmed
Summary: There is a clinical need for efficient eye drop formulations to treat posterior ocular segment diseases non-invasively. Cell penetrating peptides (CPPs), TAT, and penetratin are inferred as the most efficient penetration enhancers for drug delivery to the fundus oculi via topical eye drop instillation, but further high-quality experimental studies are needed for quantitative efficacy confirmation.
Article
Pharmacology & Pharmacy
Febri Annuryanti, Juan Dominguez-Robles, Qonita Kurnia Anjani, Muhammad Faris Adrianto, Eneko Larraneta, Raghu Raj Singh Thakur
Summary: This study utilized 3D bioprinting technology to fabricate polycaprolactone (PCL) implants loaded with triamcinolone acetonide (TA). The implants were of different shapes and drug loadings, and the results showed successful incorporation of TA within the PCL matrix. The drug release data demonstrated that filament-shaped implants had the highest cumulative drug release, and a biocompatibility study confirmed their safety for ocular application.
Article
Ophthalmology
Yi-Ran Chiou, Yu-Sheng Chang, Chin-Fang Su, Tzu-Hao Li, Chien-Chih Lai, De-Kuang Hwang, Fang-Yi Wu, Yu-Fan Chang
Summary: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing posterior ocular ischaemic events (OIE), including retinal vein occlusion (RVO), retinal artery occlusion (RAO), and ischaemic optic neuropathy (ION). Comorbidities such as end-stage renal disease (ESRD), hypertension, and congestive heart failure are associated with RVO development, while hypertension and ischemic stroke increase the risk of RAO. ESRD is associated with ION, and intravenous steroid use is associated with the development of RVO.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marco Coassin, Alessandro Arrigo, Federico Ricci, Raffaella Rosa, Roberto Gattegna, Alessandro Pupino, Jose Manuel Benitez Del Castillo, Stefano Bonini
Summary: The technological breakthroughs in mini-invasive vitreo-retinal surgery have improved the perioperative management and outcomes for millions of patients. Common procedures include vitrectomy, episcleral surgery, intravitreal injections, and laser photocoagulation. Postoperative side effects may include ocular surface disbalance and discomfort symptoms.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rosa M. Romero-Castro, Matilde Ruiz-Cruz, Claudia Alvarado-De la Barrera, Maria G. Gonzalez-Cannata, Yara A. Luna-Villalobos, Ana K. Garcia-Morales, Yuria Ablanedo-Terrazas, Mauricio Gonzalez-Navarro, Santiago Avila-Rios
Summary: This study describes the ophthalmological fundoscopic findings of COVID-19 patients admitted to the intensive care unit in Mexico City. More than one-third of the patients had ocular manifestations, with optic nerve inflammation, microvasculature occlusion, and major vascular occlusions being the most common findings.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Review
Materials Science, Biomaterials
Yun Su, Xianqun Fan, Yan Pang
Summary: Numerous novel nano-based ocular drug delivery systems have been developed to overcome the limitations of conventional drug delivery systems and have shown promising results in ocular disease models and clinical practice. Topical instillation of eye drops is the most common route for administering therapeutics to the eye, but efficiently treating posterior ocular diseases through this route remains a major challenge. Efforts have been dedicated to developing novel nano-based drug delivery systems that facilitate drug delivery to the retina by increasing retention time, promoting drug penetration, and targeting specific cells or tissues.
BIOMATERIALS SCIENCE
(2023)
Review
Ophthalmology
Elham Sadeghi, Raziyeh Mahmoudzadeh, Sunir J. Garg, M. Hossein Nowroozzadeh
Summary: The SARS-CoV-2 pandemic has had a significant impact on eye care worldwide. While vaccination has been effective in reducing the spread and severity of COVID-19, there have been reports of complications to the posterior segment of the eye after vaccination, including retinal vascular occlusion, uveitis, and central serous chorioretinopathy. These complications are rare but require prompt diagnosis and management to prevent serious visual morbidity.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Materials Science, Biomaterials
Yu Wu, Lalitkumar K. Vora, Deepakkumar Mishra, Muhammad Faris Adrianto, Shilpkala Gade, Alejandro J. Paredes, Ryan F. Donnelly, Thakur Raghu Raj Singh
Summary: An alternative system of nanosuspensions (NS) and dissolving microneedles (MNs) was developed for the minimally invasive transscleral delivery of hydrophobic drugs. The optimized NS-loaded MNs demonstrated higher drug deposition and better penetration compared to plain drug-loaded MNs. The developed hybrid system showed excellent biocompatibility with ocular tissues and could potentially be used as an effective and minimally invasive technology for the treatment of retinal diseases.
BIOMATERIALS ADVANCES
(2022)
Article
Oncology
Hamidu Hamisi Gobeka, Mustafa Dogani, Ibrahim Ethem Ay, Eda Erdal
Summary: This study found that the consumption of whey protein powder is associated with changes in the microstructure and microvascular morphology of the retina, choroid, and optic nerve head. Paying attention to these clinical aspects during ocular exams in bodybuilders who consume nutritional supplements may be critical.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Pharmacology & Pharmacy
Andrea Gabai, Marco Zeppieri, Lucia Finocchio, Carlo Salati
Summary: Innovative drug delivery systems have been developed for ocular posterior segment and retina treatments, including nanotechnology, novel matrices, and non-traditional strategies. This mini-review highlights promising strategies reported in the literature to overcome anatomical and physiological barriers and discusses challenges related to safety, efficacy, patient compliance, and sustained drug delivery. The clinical application of these approaches can contribute to standardized use of drug delivery systems and personalized therapeutic options for ocular pathologies.
Article
Pharmacology & Pharmacy
Angela V. F. Alves, Carlisson R. Melo, Jose L. Chagas-Neto, Ricardo G. Amaral, Sergio R. Ambrosio, Monique R. Moreira, Rodrigo C. S. Veneziani, Juliana C. Cardoso, Patricia Severino, Rogerio O. Gondak, Eliana B. Souto, Ricardo L. C. de Albuquerque-Junior
Summary: The antitumor activity of inclusion complexes formed between ent-kaurenoic acid (ERKA) and beta-cyclodextrin (ERKA:beta-CD) was studied in mice, and it was found that ERKA:beta-CD300 showed significant tumor growth inhibition without side effects. This antitumor activity may be attributed to the inhibition of the NF-kB signaling pathway and LDH activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Karine Cappuccio de Castro, Julia Cedran Coco, Erica Mendes dos Santos, Janaina Artem Ataide, Renata Miliani Martinez, Monica Helena Monteiro do Nascimento, Joao Prata, Pedro Ricardo Martins Lopes da Fonte, Patricia Severino, Priscila Gava Mazzola, Andre Rolim Baby, Eliana Barbosa Souto, Daniele Ribeiro de Araujo, Andre Moreni Lopes
Summary: This paper reviews the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation in the past 10 years. It focuses on the progress of drug delivery systems (e.g. micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, polymersomes and niosomes) and discusses the benefits of Pluronic (R) triblock copolymers as biological response modifiers and pharmaceutical additives, adjuvants, and stabilizers. The paper also highlights the advantages and limitations of developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment, as well as innovative examples for improving tumor cytotoxicity while reducing side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Review
Immunology
Aleksandra Zielinska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Ryszard Slomski, Eliana B. Souto
Summary: This study discusses the use of monoclonal antibodies for targeted drug delivery in the treatment of COVID-19. It proposes the use of solid lipid nanoparticles (SLN) loaded with tocilizumab (TCZ) and cannabidiol (CBD) for oral administration. TCZ attenuates cytokine storm in SARS-CoV-2 infected patients, while CBD has anti-inflammatory properties and can modulate gene expression. The use of SLN for oral administration of TCZ-tailored CBD-loaded SLN shows potential in managing SARS-CoV-2 and related infections. Rating: 7/10
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ian M. R. Blanco, Raquel de Melo Barbosa, Julita M. P. Borges, Silvio A. B. Vieira de Melo, Ramon dos Santos El-Bacha, Cesar Viseras, Patricia Severino, Elena Sanchez-Lopez, Eliana B. B. Souto, Elaine Cabral-Albuquerque
Summary: Traditional medicine uses resin oils from plants for medicinal purposes, and this study focuses on understanding their pharmacological properties. Liposomes containing resin oils or extracts from Copaifera sabulicola leaves were prepared and characterized. The liposomes showed cytotoxic effects against cancer cells and have potential applications in chemotherapy.
Article
Biochemistry & Molecular Biology
Andrea V. Machado, Luana R. O. Menezes, Adilson A. M. Santana, Maria N. Marques, Adriana K. de Lima, Amanda Cano, Patricia Severino, Eliana B. Souto, Juliana C. Cardoso
Summary: This work describes a new hair dyeing method using geniposide to react with the amino group in hair keratin. The study evaluated the effects of reaction conditions on color change, hair morphology, and mechanical properties. The results showed that geniposide treatment can significantly change hair color and affect its mechanical properties and morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Pharmacology & Pharmacy
Camilla A. S. Valenca, Ana A. T. Barbosa, Silvio S. Dolabella, Patricia Severino, Carla Matos, Karolline Krambeck, Eliana B. Souto, Sona Jain
Summary: The global problem of antibiotic resistance is a serious threat to the treatment of infectious diseases. New antimicrobials and improved delivery systems are needed. Bacterial secondary metabolites have potential as antimicrobial agents, but few molecules make it to the clinical phase.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cristina Galocha-Leon, Cristina Antich, Ana Voltes-Martinez, Juan A. Marchal, Mireia Mallandrich, Lyda Halbaut, Maria J. Rodriguez-Lagunas, Eliana B. Souto, Beatriz Clares-Naveros, Patricia Galvez-Martin
Summary: This study developed a hydrogel loaded with human mesenchymal stromal cells (hMSCs) for the treatment of superficial skin injuries. The hydrogel, using poloxamer 407 as a biomaterial, showed excellent physical, mechanical, morphological, and biological properties. It demonstrated high swelling capacity and did not affect the viability and healing capacity of keratinocytes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Marismar F. do Nascimento, Clauberto R. de Oliveira, Juliana C. Cardoso, Natalia C. T. Bordignon, Rogerio Gondak, Patricia Severino, Eliana B. Souto, Ricardo L. C. de Albuquerque Jr
Summary: This study aimed to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid. The results showed that GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Jose M. de Oliveira Junior, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this work was to develop a dense lamellar scaffold for tracheal tissue regeneration using phenolic compounds from Psidium guajava Linn. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed chemical interactions between the polymers and cross-linking of phenolic compounds. Morphological analyses showed scaffolds with porosity and a porous surface structure. The addition of phenolic compounds modulated the morphological and mechanical properties of the scaffolds.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carlotta Coccolini, Elisa Berselli, Cristina Blanco-Llamero, Faezeh Fathi, M. Beatriz P. P. Oliveira, Karolline Krambeck, Eliana B. Souto
Summary: Lactoferrin (Lf) is a glycoprotein with the ability to bind iron and exhibits numerous biological activities such as antibacterial, antiviral, antifungal, anti-tumour, anti-obesity, antioxidant, anti-inflammatory, and immunomodulatory effects. It has shown potential in cancer treatment, neuroprotection, and even as a prophylaxis for COVID-19.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Lorena Bonilla-Vidal, Marta Switalska, Marta Espina, Joanna Wietrzyk, Maria Luisa Garcia, Eliana B. Souto, Anna Gliszczynska, Elena Sanchez Lopez
Summary: APG-NLC containing rosehip oil was developed, which exhibited favorable physicochemical characteristics, long-term stability, sustained release of APG, and cytotoxicity in cancer cells without affecting healthy cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Smita Khairnar, Elena Sanchez-Lopez, Eliana B. Souto, Kamalinder K. Singh
Summary: Microspheres-enriched ocular gels were developed as a controlled release system for moxifloxacin hydrochloride. The ocular gel containing microspheres showed improved drug release, penetration, and therapeutic efficacy, with reduced administration frequency, which may improve patient compliance to ocular treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Andy Wai Kan Yeung, Natalia Ksepka, Maima Matin, Dongdong Wang, Eliana B. Souto, Jivko Stoyanov, Javier Echeverria, Devesh Tewari, Jaroslaw Olav Horbanczuk, Massimo Lucarini, Alessandra Durazzo, Joanna Marchewka, Vasil Pirgozliev, Ren-You Gan, Nikolay T. Tzvetkov, Kamil Wysocki, Farhan Bin Matin, Olena Litvinova, Anupam Bishayee, Hari Prasad Devkota, Amr El-Demerdash, Mladen Brncic, Antonello Santini, Olaf. K. Horbanczuk, Michel-Edwar Mickael, Michal Lawinski, Niranjan Das, Bodrun Naher Siddiquea, Dalibor Hrg, Atanas G. Atanasov
Summary: This study provides a quantitative literature analysis on the influence of diet on non-alcoholic fatty liver disease (NAFLD). The analysis reveals that China and the United States are significant contributors to this field, and key dietary compounds such as resveratrol and polyphenols are frequently mentioned and cited, showing potential benefits for NAFLD in both human and animal studies.
ANIMAL SCIENCE PAPERS AND REPORTS
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
