期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 88, 期 1, 页码 505-511出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2011.07.041
关键词
Silver nanoparticles; Stability; Antimicrobial activity; Polyethyleneimine; Sodium borohydride; Cytotoxicity
资金
- National Institute of Crop Science, Rural Development Administration (RDA), Republic of Korea [PJ0073852010]
- Rural Development Administration (RDA), Republic of Korea [PJ00738520111142300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion. (C) 2011 Elsevier B.V. All rights reserved.
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