Article
Engineering, Biomedical
Jingyi Sheng, Yang Liu, He Ding, Linyuan Wu, Lan Liu, Guangxiang Si, Yan Shen, Fang Yang, Ning Gu
Summary: This study demonstrates the potential of magnetic targeting as an effective strategy for delivering cancer vaccines and activating the immune response. By targeting antigen-loaded magnetic liposomes to the lymph nodes, the population of active dendritic cells and cytotoxic T lymphocytes is increased, resulting in effective tumor growth inhibition.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Immunology
Lorenzo Piermatteo, Stefano D'Anna, Ada Bertoli, Maria Bellocchi, Luca Carioti, Lavinia Fabeni, Mohammad Alkhatib, Simone La Frazia, Miriam Lichtner, Claudio Mastroianni, Giuseppe De Sanctis, Massimo Marignani, Caterina Pasquazzi, Nerio Iapadre, Giustino Parruti, Giuseppina Cappiello, Jacopo Vecchiet, Vincenzo Malagnino, Sandro Grelli, Francesca Ceccherini-Silbertein, Massimo Andreoni, Loredana Sarmati, Valentina Svicher, Romina Salpini
Summary: 17.7% of HBV-D infected patients carry at least one vaccine-escape mutation, and the proportion of patients with complex mutations is increasing over time. Complex mutations are associated with lower HBsAg levels and HBsAg negativity despite HBV-DNA positivity.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Pharmacology & Pharmacy
Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun, Jinping Dong, Guohua Yu, Zhiqin Gao, Bo Zhang, Guixiang Tian
Summary: In this study, glycyrrhetinic acid and hyaluronic acid-modified liposomes were prepared for co-delivery of curcumin and berberine for the treatment of hepatocellular carcinoma. The results showed that the liposomes could accumulate in tumor tissues and be taken up by relevant cells simultaneously. They exhibited stronger pro-apoptotic and anti-proliferation effect compared to free curcumin, and could inhibit the activation of hepatic stellate cells and restrain drug resistance of tumor cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Sibel Emir Diltemiz, Maryam Tavafoghi, Natan Roberto de Barros, Masamitsu Kanada, Jyrki Heinamaki, Christopher Contag, Stephanie K. Seidlits, Nureddin Ashammakhi
Summary: Cells are the fundamental units in biological systems, and simulating their size, function, and complexity is a key goal in developing new therapeutic strategies. Recent advancements in chemistry, synthetic biology, and material science have led to the development of cell membrane-based drug delivery systems known as artificial cells or protocells. These artificial cells, inspired by natural cells or cell membranes, have shown effective and controlled release of various therapeutics and are expected to have a significant impact on therapeutic designs with increasing complexity.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Immunology
Jieru Yang, Farrhana Firdaus, Armira Azuar, Zeinab G. Khalil, Nirmal Marasini, Robert J. Capon, Waleed M. Hussein, Istvan Toth, Mariusz Skwarczynski
Summary: Utilizing cell-penetrating peptides for delivering lipopeptide-based vaccines combined with multilamellar liposomes can efficiently trigger immune responses and generate high antibody titers with high opsonic activity against pathogenic GAS strains. This approach shows promising potential for liposome-based GAS vaccine development.
Article
Immunology
Te-Wei Cheng, Jeng-Fu Yang, Yi-Yu Chen, Kuan-Ta Wu, Meng-Szu Lee, Hsiang-Ju Kuo, Tzu-Chun Lin, Chao-Ling Wang, Meng-Hsuan Hsieh, Chia-Yi Lin, Batbold Batsaikhan, Chi-Kung Ho, Chia-Yen Dai
Summary: The prevalence of hepatitis B virus (HBV) infection among college-aged individuals in Taiwan after mass vaccination remains uncertain. A study was conducted to investigate the prevalence of hepatitis B markers in different birth cohorts. The results showed a decreasing trend in HBsAg and anti-HBs seropositive rates among college students in the Kaohsiung area. The status of HBsAg was found to be a predictive factor of abnormal ALT levels, and a time effect on anti-HBs seropositivity for DNA recombinant vaccine was observed.
Review
Pharmacology & Pharmacy
Rabin Neupane, Sai H. S. Boddu, Mariam Sami Abou-Dahech, Rinda Devi Bachu, David Terrero, R. Jayachandra Babu, Amit K. Tiwari
Summary: Transdermal drug delivery is a promising alternative for cancer treatment, reducing dose frequency and severity of adverse effects. It can be used for localized tumor treatment and sustained delivery of low-dose chemotherapeutics or vaccines. However, challenges remain in designing effective transdermal formulations.
Article
Biophysics
Jing-yan Tian, Chang-liang Chi, Ge Bian, Dong Xing, Feng-jun Guo, Xiao-qing Wang
Summary: The development of genistein and plumbagin co-encapsulating liposomes with PSMA specific antibodies showed selective targeting of prostate cancer cells, resulting in over 90% decrease in cell proliferation. This strategy may potentially be applied to encapsulate other drugs for inhibiting the growth of different types of cancers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Patrick M. Glassman, Elizabeth D. Hood, Laura T. Ferguson, Zongmin Zhao, Don L. Siegel, Samir Mitragotri, Jacob S. Brenner, Vladimir R. Muzykantov
Summary: Drug delivery research involves various types of carriers such as proteins, macromolecules, nanocarriers, and cells. Liposomes and lipid nanoparticles are popular artificial nanocarriers, while red blood cells are attractive natural carriers. Recent studies show that RBC-based drug carriers may have unique pharmacokinetic and biodistribution characteristics.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Veronica Duran, Elena Grabski, Constantin Hozsa, Jennifer Becker, Hanzey Yasar, Joao T. Monteiro, Bibiana Costa, Nicole Koller, Yvonne Lueder, Bettina Wiegmann, Gudrun Brandes, Volkhard Kaever, Claus-Michael Lehr, Bernd Lepenies, Robert Tampe, Reinhold Foerster, Berislav Bosnjak, Marcus Furch, Theresa Graalmann, Ulrich Kalinke
Summary: The antibiotic treatment of tuberculosis is complex and lengthy, and can lead to poor patient compliance and the selection of multi-drug resistant bacteria. Encapsulating levofloxacin in lipid nanocarriers functionalized with fucosyl residues has shown to target MMR-positive cells more efficiently, improving the delivery and efficacy of the antibiotic in clearing the pathogen. Carbohydrate-functionalized nanocarriers present a promising tool for enhancing TB treatment by targeted antibiotic delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Elana Ben-Akiva, Johan Karlsson, Shayan Hemmati, Hongzhe Yu, Stephany Y. Tzeng, Drew M. Pardoll, Jordan J. Green
Summary: Nanoparticle-based mRNA cancer vaccines show great promise for personalized cancer treatments. We developed a bioreducible lipophilic poly(beta-amino ester) nanocarrier that can efficiently deliver multiple antigen-encoding mRNAs and nucleic acid-based adjuvants to dendritic cells. The engineered nanocarrier facilitated targeted delivery without the need for surface functionalization and resulted in robust CD8+ T cell responses and efficient antitumor therapy in murine melanoma and colon adenocarcinoma models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
Fengping Wu, Yikai Wang, Dandan Cui, Yan Tian, Rui Lu, Chenrui Liu, Mei Li, Yaping Li, Ning Gao, Zicheng Jiang, Xuemei Li, Song Zhai, Xin Zhang, Xiaoli Jia, Shuangsuo Dang
Summary: The study investigated the efficacy and safety of peg-IFN alpha-2b in re-treating patients with HBsAg recurrence after stopping peg-IFN alpha-based regimens. The results showed that a short-course of peg-IFN alpha-2b re-treatment significantly improved HBsAg clearance and seroconversion rates in patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Milda Naciute, Tamara Kiwitt, Roslyn A. Kemp, Sarah Hook
Summary: The study found that bacteria biohybrid-based vaccine delivery systems have the potential to enhance immune stimulation and may be used for treating colorectal cancer. Experiments demonstrated that emulsion and liposome biohybrid vaccines have high therapeutic potential, promoting CD8(+) T cell infiltration and inhibiting tumor growth.
Article
Biochemistry & Molecular Biology
Su-Im Kim, Jae Yeong Ha, Song-Yi Choi, Su-Hyung Hong, Heon-Jin Lee
Summary: Extracellular vesicles, including bacterial vesicles, can be used as vehicles for delivering genetic materials, such as genes and RNA, into recipient cells. This study demonstrated the successful delivery of GFP genes and precursor microRNA into murine microglial cells using bacterial vesicles.
Article
Chemistry, Multidisciplinary
Nianxiu Duan, Junjun Li, Sha Song, Feng Wang, Yiwei Yang, Di Nie, Caifen Wang, Yingjie Sheng, Yali Tao, Jie Gao, Can Xu, Yan Wei, Yong Gan
Summary: The selective delivery of chemotherapeutics and modulators to tumor cells and activated pancreatic stellate cells (aPSCs) using a prodrug-based smart liposome system shows promising efficacy for pancreatic cancer therapy, with increased accumulation in tumors and reduced side effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)