期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 84, 期 2, 页码 406-412出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2011.01.034
关键词
Micro-structure; Lipid nanoparticles; NLCs; DPLNs; ESR; LCSM
资金
- 973 Program of Chinese government [2009C930300]
- National Science Foundation of People's Republic of China [30430770]
Drug-phospholipid lipid nanoparticles (DPLNs) are prepared by incorporating drug-phospholipid complexes (DPCs) with a liquid lipid. DPLNs demonstrated interesting properties including increased encapsulation capacity, improved stability and controlled drug release profile. A comprehensive characterization of DPLNs was presented and then a schematic model was suggested according to the characterization results. Transmission electron microscopy and scanning electron microscope measurements showed the morphology of DPLNs. X-ray diffraction exhibited a predominantly amorphous structure for DPCs and totally amorphous for DPLNs. Laser confocal scanning microscopy revealed the relative position of DPCs and liquid lipid, showing that DPLNs formed a homogeneous system. Fluorescence spectra and electron spin resonance further confirmed the chemical environment inside the DPLNs in a non-invasive way. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据