Article
Parasitology
Johanna Zech, Ron Dzikowski, Karina Simantov, Jacob Golenser, Karsten Maeder
Summary: The study demonstrates successful transdermal delivery of artemisone and artesunate for malaria treatment, with ART-ME being about three times more efficient than artesunate-ME in eliminating malaria parasites. This innovative delivery method shows potential for transdermal treatment of malaria.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2021)
Article
Pharmacology & Pharmacy
Mehdi Nouraei, Chereen Collymore, Levente Diosady, Edgar Acosta
Summary: Lecithin-linker microemulsions were proposed as a platform for designing a fully dilutable selfmicroemulsifying drug delivery system (SMEDDS). Introducing ibuprofen required restoring a highly hydrophilic linker to achieve full dilutability, resulting in significantly increased plasma concentration profiles with the ibuprofen-loaded SMEDDS.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Lina Shen, Xiaolin Hou, Zhi Wang, Teng Guo, Zehui He, Shuyao Ruan, Zhenda Liu, Hang Ruan, Yongtai Zhang, Nianping Feng
Summary: Microemulsions can be used as a carrier to enhance the solubility and skin permeability of total flavones of Arisaematis rhizoma for transdermal delivery. By adding 1% sodium hyaluronate, transparent microemulsion-based hydrogels with pseudoplastic-fluid and shear-thinning characteristics were obtained. Nanoscale droplets of microemulsions migrate in the gel network, with their migration capacity and transdermal permeation flux negatively correlated with sodium hyaluronate concentration.
Article
Chemistry, Multidisciplinary
Beibei Lu, Yiyang Bo, Mingjie Yi, Zhenyuan Wang, Jichuan Zhang, Zhenye Zhu, Yanli Zhao, Jiaheng Zhang
Summary: The study successfully synthesized an L-(-)-carnitine-based ionic liquid and developed IL/O ME to improve drug solubility and protein permeability.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Beibei Lu, Tianqi Liu, Hao Wang, Chengyu Wu, Hanjun Chen, Zhe Liu, Jiaheng Zhang
Summary: Transdermal drug delivery system has several advantages, and ionic liquids play an important role in transdermal drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Chemistry, Multidisciplinary
Vivek P. Chavda, Shilpa Dawre, Anjali Pandya, Lalitkumar K. Vora, Dharti H. Modh, Vidhi Shah, Divyang J. Dave, Vandana Patravale
Summary: The development of novel long-acting parenteral formulations based on lipid-based liquid crystals has been encouraged by the need for long-term treatments of chronic diseases. These liquid crystal systems, formed by amphiphilic molecules, spontaneously form liquid crystal nanoparticles in aqueous tissue environments, creating an in-situ long-acting sustained-release depot for extended treatment efficacy. This manuscript summarizes the different types of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Md. Korban Ali, Rahman Md Moshikur, Masahiro Goto, Muhammad Moniruzzaman
Summary: Ionic liquids with tunable properties have been extensively studied and applied in drug delivery, addressing the challenges in conventional drug delivery methods.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Adina Raducan, Miruna Stan, Sorina Nicoleta Voicu, Bodgan Trica, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor, Catalin Ionut Mihaescu, Cristian Petcu, Ludmila Otilia Cinteza
Summary: This study aimed to develop and characterize new gel microemulsions for topical cosmetic applications, using grape seed oil and three different water-soluble polymers. Physico-chemical characterization and cytotoxicity evaluation showed that the gel microemulsions could effectively incorporate and control the release of hydrophobic active ingredients.
Article
Pharmacology & Pharmacy
Nancy M. Lotfy, Mohammed Abdallah Ahmed, Nada M. El Hoffy, Ehab R. Bendas, Nadia M. Morsi
Summary: This study aims to improve the therapeutic efficiency of the anti-hyperglycemic drug Canagliflozin (CFZ) by formulating it in a transdermal nanostructured liquid crystal gel matrix (NLCG). The results show that the optimized CFZ-NLCG2 formulation has superior permeation parameters and anti-hyperglycemic activity compared to the oral route. These findings confirm the success of CFZ-NLCG2 in transdermal delivery, bypassing first-pass effect and minimizing gastrointestinal side effects.
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Cristina Lavinia Nistor, Ioana Catalina Gifu, Cristian Petcu, Daniel Dumitru Banciu, Adela Banciu, Ludmila Otilia Cinteza
Summary: This study aimed to develop new microemulsion systems for topical use and identify a suitable water-soluble polymer for gel microemulsions. The efficacy of the developed microemulsion and gel microemulsion systems in delivering curcumin into the skin was also studied. A pseudo-ternary phase diagram was developed using specific ingredients, and physicochemical characterization and in vitro permeation studies were conducted.
Review
Instruments & Instrumentation
Mori Dhaval, Poonam Vaghela, Kajal Patel, Keshvi Sojitra, Mohini Patel, Sushma Patel, Kiran Dudhat, Sunny Shah, Ravi Manek, Ramesh Parmar
Summary: Lipid-based emulsion systems have gained popularity for improving solubility of water-insoluble drugs, along with advantages such as enhanced permeability and protection against pre-systemic metabolism. This article provides a comprehensive review of critical properties of lipid-based emulsion systems, including different types of emulsions, stabilization mechanisms, preparation methods, and evaluation techniques.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Enxue He, Hailing Li, Xiaokun Li, Xunxun Wu, Kun Lei, Yong Diao
Summary: In this study, a hydrogel-based microemulsion drug delivery system was developed to improve the efficacy of indirubin for the treatment of psoriasis. Results showed that the prepared formulation could effectively improve psoriasis symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Amitkumar Virani, Vinam Puri, Hana Mohd, Bozena Michniak-Kohn
Summary: The present study aimed to evaluate the transdermal delivery of Oxcarbazepine (OXC) from microemulsions using different penetration enhancers. The results showed that all penetration enhancers improved the rate of permeation of OXC compared to the control. Microemulsions prepared using cineole, Tween 80 and Transcutol P (TRC) were shown to provide the best penetration enhancement for OXC.
Article
Chemistry, Physical
Jinpeng Liu, Ranran Cheng, Kirsten Heimann, Zhongni Wang, Jinying Wang, Feng Liu
Summary: The study successfully developed temperature-sensitive lyotropic liquid crystals (LLC) that can adjust their structure to match human body temperature, showing potential for application as transdermal drug delivery systems by influencing their composition and temperature.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Ming Yuan, Jiangxiu Niu, Qinghan Xiao, Huiyuan Ya, Yansong Zhang, Yanli Fan, Lingmei Li, Xueke Li
Summary: This study investigated the use of hyaluronic acid-modified transfersomes to enhance the transdermal delivery of indomethacin. The results showed that the prepared transfersomes had good encapsulation efficiency and nanometric particle size. The transfersomes were further incorporated into a hydrogel to prolong retention capacity on the skin. In vitro experiments demonstrated sustained drug release, improved drug permeation, and penetration of the transfersomes/gel across the skin. The study also revealed that hyaluronic acid improved the transdermal effect by changing the microstructure of skin layers and decreasing skin barrier function.
Article
Pharmacology & Pharmacy
Howaida E. Abdelrahman, Ebtessam A. Essa, Gamal M. El Maghraby, Mona F. Arafa
Summary: This study introduced a co-grinding approach to enhance the dissolution of nimodipine and prepared ODTs. The optimized formulations showed improved dissolution performance and release efficiency, which could potentially increase the bioavailability for patients.
PHARMACEUTICAL SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Amal A. Sultan, Nourhan F. El Nashar, Shimaa M. Ashmawy, Gamal M. El Maghraby
Summary: The aim of this study was to enhance the intestinal absorption and oral bioavailability of poorly absorbable fexofenadine HCl (FEX-HCl) using cubosomes. The results showed that cubosomes could improve drug absorption and in vivo anti-inflammatory effect, indicating their potential as novel carriers for enhancing drug bioavailability.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Noha D. Fayed, Mona F. Arafa, Ebtesam A. Essa, Gamal M. El Maghraby
Summary: The aim of this study was to improve the dissolution rate and intestinal absorption of lopinavir. Co-processing with menthol resulted in the formation of lopinavir-menthol co-crystals, which significantly enhanced the dissolution rate of lopinavir. The absorption of lopinavir in the intestine was affected by P-glycoprotein, and co-perfusion with menthol increased the intestinal permeability of lopinavir.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Noha D. Fayed, Ebtesam A. Essa, Gamal M. El Maghraby
Summary: The study demonstrated that co-processing with menthol enhanced the intestinal absorption of lopinavir, improving the treatment efficacy.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Ebtehal M. Dorgham, Gamal M. El Maghraby, Ebtessam A. Essa, Mona F. Arafa
Summary: This study aimed to enhance the dissolution rate of eslicarbazepine acetate (ESL) by forming eutectic systems with tartaric acid or citric acid. The eutectic system formation with both tartaric and citric acid was confirmed, with the optimum molar ratio being 1:1 for both substances. The co-processing of ESL with either citric acid or tartaric acid resulted in significantly enhanced dissolution rate, attributed to the combined effect of eutexia and pH modification.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Amal A. Sultan, Ghada A. Saad, Gamal M. El Maghraby
Summary: This study investigated the use of bilosomes encapsulating absorption enhancers as carriers for enhancing the oral absorption and cytotoxicity of doxorubicin. The bilosomes were found to significantly improve the intestinal absorption and cytotoxicity of doxorubicin against breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Microbiology
Amal Abo M. Kamer, Noha M. Amer, Ahmed A. Abdelmegeed, Gamal M. El Maghraby, Noha M. Gamaleldin
Summary: Researchers used nano-drug delivery systems to enhance the antimicrobial activity of existing antibiotics against Carbapenemase Resistant Enterobacteriaceae (CRE) and extended spectrum beta-lactamases producing bacteria (ESBL). The optimization of surfactant nanovesicles improved the efficacy of meropenem, ertapenem, and tigecycline. The results showed that the surfactant vesicles reduced the MIC values of the drugs and had potential adhesion/fusion with bacterial cells.
Article
Parasitology
Hager S. Zoghroban, Basma M. Elmansory, Yasmine Amr Issa, Amira K. Eltokhy, Hend S. Abo Safia, Gamal M. El Maghraby, Amina M. Salama
Summary: This study investigates the effects of levamisole and spiramycin on the early and late stages of experimental toxoplasmosis. The results show that the combination of spiramycin and levamisole treatment significantly decreases the burden of Toxoplasma brain cyst, increases IFN-gamma level, and improves histopathological features. Levamisole effectively modulates Toxoplasma-induced immune responses, leading to remission of chronic toxoplasmosis.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rania K. Eid, Mona F. Arafa, Dalia S. Ashour, Ebtessam A. Essa, Eman S. El-Wakil, Salwa S. Younis, Gamal M. El Maghraby
Summary: This study evaluated niosomes as potential carriers for enhancing the efficacy of norfloxacin against Toxoplasma gondii. The niosomes were prepared using Span 60 and cholesterol and incorporated Gelucire 48/16 or Tween 80. In vitro and in vivo experiments showed that niosomal encapsulation of norfloxacin resulted in faster drug release and significantly reduced EC50 against tachyzoites. The mice infected with Toxoplasma showed a reduction in tachyzoite count after treatment with niosomes encapsulated norfloxacin. These results suggest the potential of surfactant vesicles for enhancing the efficacy of norfloxacin against Toxoplasma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Muhammad Embaby, Gamal M. El Maghraby, Mohamed A. Osman, Amal A. Sultan
Summary: This study investigates the regional difference in linagliptin intestinal membrane transport and the effects of carvedilol, atorvastatin, and bile salts on intestinal absorption of linagliptin. The results show incomplete absorption of linagliptin from the explored intestinal segments, with absorption decreasing as movement progresses distally through the small intestine before increasing at the ascending colon. P-glycoprotein (P-gp) efflux is identified as a possible mechanism for reduced linagliptin intestinal absorption. Co-perfusion with carvedilol, atorvastatin, or bile salts significantly enhances linagliptin absorption, suggesting P-gp efflux inhibition as one possible mechanism for enhanced linagliptin intestinal membrane transport.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ahmed S. Kamel, Soha M. El-Masry, Haidy Abbas, Fatma Mkh Ibrahim, Hager S. Zoghroban, Gamal M. El Maghraby
Summary: The aim of this study was to improve the dissolution rate and in vivo efficacy of flubendazole against trichinella spiralis. Flubendazole nanocrystals were successfully developed through controlled anti-solvent recrystallization. The nanocrystals showed spherical shape and a size of 743.1 nm, with the formulation employing 0.2% Poloxamer 407 as a stabilizer being optimal. The optimal formulation exhibited fast dissolution and significantly improved the eradication of intestinal trichinella and larval count reduction in migrating and encysted phases compared to unprocessed flubendazole.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amr Zidan, Amira A. EL Saadany, Gamal M. El Maghraby, Amany A. Abdin, Sabeha E. Hedya
Summary: The aim of this study was to investigate the potential cardioprotective and anti-cancer effects of carvedilol (CAR) either free or as loaded nano-formulated with or without doxorubicin (DOX) in solid Ehrlich carcinoma (SEC)-bearing mice. The results showed that CAR, when used in combination with DOX and loaded into PLGA or Niosomes, exhibited better cardioprotective effects and cytotoxicity against cancer cells, suggesting its potential as an adjuvant therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ebtessam Essa, Manna Amin, Amal Sultan, Mona Arafa, Gamal El Maghraby, Christopher Mcconville
Summary: This study aimed to enhance the dissolution rate of Hydrochlorothiazide (HTZ) using hot melt extrusion (HME). The results showed significant improvement in HTZ dissolution rate after HME, and co-perfusion with Poloxamer188 or Cremophore RH40 improved the intestinal absorption of HTZ.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Asmaa M. El Shiekh Ali, Gamal M. El Maghrabyl, Abdelaziz E. Abdelaziz, Ahmed M. Soliman, Eman M. Saied, Eman A. Mazyed
Summary: The objective of this study was to improve the dissolution rate and anti-fungal activity of fluconazole by preparing solid mixtures with menthol. The developed solids were characterized using various techniques and the dissolution of fluconazole was monitored. A menthol-containing oral dispersible tablet was prepared and its prophylactic and therapeutic effects were evaluated using a mouse oral candida model. The results showed that the menthol-containing tablet exhibited improved anti-candida activity compared to fluconazole tablet.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Dermatology
Yomna Mazid El-Hamd Neinaa, Myada Abd Elmohsen Mahmoud, Gamal Mohamed El Maghraby, Zeinab Abd Elsamd Ibrahim
Summary: In recent decades, prostaglandins have been recommended as a new therapy for stable vitiligo. This study aimed to compare the effectiveness of two subtypes of prostaglandins (PGE2 and PGF2a) in combination with NB-UVB phototherapy. The study included 30 patients with stable non-segmental vitiligo who were assigned to three groups. The results showed that the therapeutic efficacy of intradermal injection of PGE2 or PGF2a, combined with NB-UVB phototherapy, was comparable and significantly higher than NB-UVB alone. However, PGE2 was associated with earlier onset of repigmentation and higher patient satisfaction compared to PGF2a. In conclusion, both PGE2 and PGF2a intradermal injections are simple and affordable techniques for the treatment of stable vitiligo with no reported side effects and good patient satisfaction.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)