Article
Chemistry, Physical
Umit Celik, Kuebra Celik, Ihsan Kehribar, Suleyman Celik, Mehmet Z. Baykara
Summary: Forming a fundamental understanding of tribological processes on the atomic scale has the potential to revolutionize the control of friction and wear in macroscopic mechanical systems. However, current methods for studying tribology at the nanoscale, such as atomic force microscopy, are limited in scanning speed compared to macroscopic mechanical processes. In this study, a new method combining atomic force microscopy with quartz crystal microbalance measurements is proposed for high-speed nanoscale tribology.
APPLIED SURFACE SCIENCE
(2023)
Article
Nutrition & Dietetics
Qun Wang, Bo Peng, Mingyue Song, Jun Li, Jianyin Miao, Konglong Feng, Feilong Chen, Xiaoxiang Zhai, Yong Cao
Summary: The antimicrobial peptide F1 was found to severely deform the bacterial membranes of E. coli and S. aureus, leading to leakage of cell contents and subsequent cell death. This study demonstrates the direct effect of F1 on both Gram-negative and Gram-positive bacteria through destruction of their respective phospholipid membranes.
FRONTIERS IN NUTRITION
(2021)
Article
Biophysics
Ziqi Wei, Marsha W. Rolle, Terri A. Camesano
Summary: This study successfully established a method for measuring peptide-collagen binding and provided important information on the cCBD-mediated mechanism of antimicrobial peptide binding.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Iad Alhallak, Peter J. N. Kett
Summary: Supported Lipid Bilayers (SLBs) are model biological membranes used to study biomolecule interactions. Using experiments with DOPC vesicles, we found that their adsorption and desorption onto a SiO2 surface followed a Langmuir adsorption model, with an equilibrium constant and rate constants determined.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Cell Biology
Eleni Priglinger, Juergen Strasser, Boris Buchroithner, Florian Weber, Susanne Wolbank, Daniela Auer, Eva Grasmann, Claudia Arzt, Dmitry Sivun, Johannes Grillari, Jaroslaw Jacak, Johannes Preiner, Mario Gimona
Summary: Interest in using mesenchymal stem cell derived extracellular vesicles (MSC-EVs) as therapeutic agents has grown in the past decade. This study established and verified quartz crystal microbalance (QCM) as a highly sensitive label-free immunosensing technique for characterizing clinically approved umbilical cord MSC-EVs. By using QCM along with common characterization methods, specific detection of EVs via EV and MSC markers was achieved, allowing for quantitative determination of the ratio of marker-specific EVs versus non-vesicular particles.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Chemistry, Analytical
Subramanian Suriyanarayanan, Sudip Mandal, Kothandaraman Ramanujam, Ian A. Nicholls
Summary: Proteinaceous and tunable nanostructures of zein were developed as receptors using a molecular imprinting technique. Sacrificial templates were used to control the nanostructural patterns. Highly oriented, predetermined, and uniformly grown hyperporous and nanowires motifs of zein were obtained. These zein nanostructures showed high sensitivity towards biotin or its derivatives, making them suitable for detecting relevant analytes.
Article
Engineering, Biomedical
Natthaporn Klubthawee, Giovanni Bovone, Bruno Marco-Dufort, Elia A. Guzzi, Ratchaneewan Aunpad, Mark W. Tibbitt
Summary: This study presents a moldable and biodegradable colloidal nano-network that protects and delivers antimicrobial peptides to address antimicrobial resistance. The nano-network successfully protects the peptides from enzymatic degradation and demonstrates effective killing of bacteria in vitro and ex vivo models.
ADVANCED HEALTHCARE MATERIALS
(2022)
Editorial Material
Multidisciplinary Sciences
Telmo O. Paiva, Albertus Viljoen, Yves F. Dufrene
Summary: Advancements in atomic force microscopy (AFM) techniques and methodologies in microbiology have enhanced our understanding of microbial cell surfaces. Recent studies have shown that AFM imaging of cells and membranes at or near molecular resolution enables detailed visualization of membrane-drug interactions.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Annarita Falanga, Valentina Del Genio, Stefania Galdiero
Summary: The alarming rise in antimicrobial resistance and recent viral pandemics have increased the demand for novel approaches, such as antimicrobial peptides, cell-penetrating peptides, antiviral peptides, and dendrimers, to combat bacteria and viruses effectively. Nanoplatforms constructed with peptides and dendrimers show promising potential for advanced nanosystems with diverse applications.
Article
Chemistry, Multidisciplinary
Ryongsok Chang, Evan Angelo Quimada Mondarte, Debabrata Palai, Taito Sekine, Aki Kashiwazaki, Daiki Murakami, Masaru Tanaka, Tomohiro Hayashi
Summary: Peptide-SAMs with specific zwitterionic sequences exhibit anti-biofouling properties, with EK and DK SAMs showing excellent resistance to protein and cell adhesion while ER and DR SAMs adhere proteins and cells. Surface force measurements using AFM reveal that a water-induced repulsion occurs between EK and DK SAMs within a range of about 8 nm, suggesting that interfacial water acts as a physical barrier preventing protein and cell adsorption.
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Environmental
Il Ryu Jang, Soon In Jung, Gunhee Lee, Inyong Park, Sang Bok Kim, Hoe Joon Kim
Summary: This study introduces a thermally controlled dust capturing scheme by integrating a polystyrene (PS) layer and microheater on a quartz crystal microbalance (QCM), which allows calibration of attached particle mass by measuring the resonance response and exhibits 11 times larger detectable mass range compared to a bare QCM. The heated QCMs show comparable performance to high-cost particle sensing equipment such as an aerodynamic particle sizer and optical particle counter.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Physical
L. Bar, P. Losada-Perez, J. Troncoso
Summary: The influence of peptides on the stability of lipid membranes was studied using diphenylalanine and 1,2-dimyristoyl-sn-glycero-3-phosphocholine as model systems. Different experimental techniques were used to prepare and characterize vesicles at different peptide-lipid ratios. The results showed that diphenylalanine decreased lipid molecular cooperativity and weakened membrane organization.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Multidisciplinary
Ximing Chen, Yan Ma, Wenwei Li, Qingwen Gui, Xuhua Zhan, Yaqin Lan, Weisong Pan, Tiean Zhou, Zhaohong Su
Summary: This study presents a functional coating with cell-specific adhesion and antiprotein adhesion properties prepared by electrochemical copolymerization, showing significantly improved cell adsorption and antiprotein adhesion characteristics.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Microbiology
Kathleen W. Swana, Ramanathan Nagarajan, Terri A. Camesano
Summary: Antimicrobial peptides interact with bacterial cell membranes through various mechanisms, causing cell death, but also damage mammalian cell membranes, posing a challenge to their application.
Article
Chemistry, Physical
Satoshi Ishii, Shogo Yoshimoto, Katsutoshi Hori
Summary: The research showed that Acinetobacter sp. Tol 5 has strong adhesion force, mainly achieved through the interaction between the AtaA protein on the cell surface and the surface. This adhesion force increases with the increase of AtaA molecules. Amino acid hydrolysates and deionized water can inhibit the direct interaction between cells and surfaces, respectively.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)