期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 73, 期 1, 页码 146-151出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2009.05.009
关键词
Nanocomposites; Biphasic calcium phosphate; Biomimetic; Mesenchymal stem cells
资金
- Council of Scientific and Industrial Research (CSIR)
- Network Project on Nanornaterials and Devices for Health Applications [NWP 0035]
Biphasic calcium phosphate nanoparticles comprising both hydroxyapatite (HA) and P polymorph of tricalcium phosphate (beta-TCP) have been synthesized together by a polymer matrix mediated process. The process, based on in situ mineralization of poly (vinyl alcohol), exerts a good control over the morphological features of biphasic nanoparticles. By controlling the reaction chemistry (Ca:P ratios), nanobioceramic particles having three different HA/beta-TCP ratios of 50:50, 55:45 and 60:40 respectively. As the two constituents of biphasic system (HA and beta-TCP) facilitate series of signaling cascades in osteoblast division and differentiation, the adhesion and differentiation properties of mesenchymal cells (MSCs) derived from bone marrow has been studied. (C) 2009 Elsevier B.V. All rights reserved.
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