Article
Multidisciplinary Sciences
Patrick M. Perrigue, Agata Henschke, Bartosz F. Grzeskowiak, Lucja Przysiecka, Kaja Jaskot, Angelika Mielcarek, Emerson Coy, Sergio E. Moya
Summary: Understanding the interaction between nanoparticles and cells is crucial for designing more effective nanomedicines. This study investigates the biological fate of silica nanoparticles in senescent cells, which do not divide, using various methods including microscopy and flow cytometry. The results show that the nanoparticles readily enter the senescent cells and accumulate in the cytoplasm for a long time. This study lays the foundation for the development of NP-based tools for detecting and targeting senescent cells for therapeutic purposes.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Daniel Stengel, Betuel Hilal Demirel, Patrick Knoll, Martyna Truszkowska, Flavia Laffleur, Andreas Bernkop-Schnuerch
Summary: This study evaluated the impact of polyethylene glycol (PEG) and zwitterionic surface decoration of lipid-based nanocarriers (NC) on cellular uptake. The results showed that zwitterionic lipid-based NCs exhibited better performance in terms of particle size, stability, and cellular uptake compared to PEGylated NCs. The replacement of PEG surfactants with zwitterionic surfactants may be a promising approach for intracellular drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Qingyuan Cheng, Yiping Duan, Wei Fan, Dongxu Li, Cuiwen Zhu, Tiantian Ma, Jie Liu, Mingxia Yu
Summary: This study established a cell model representing the circulatory system to investigate the cellular internalization and cytotoxicity of 6-arm PEG-amine/mPEG QDs. The results showed low cellular uptake of QDs, preservation in the Golgi apparatus, minimal acute cytotoxicity, and sub-acute cytotoxicity caused by elevated ROS generation.
Article
Biophysics
Monica Notarbartolo, Marina Massaro, Raquel de Melo Barbosa, Carlotta Emili, Leonarda Francesca Liotta, Paola Poma, Francisco M. Raymo, Rita Sanchez-Espejo, Riccardo Vago, Cesar Viseras-Iborra, Serena Riela
Summary: In recent years, there has been an increasing use of clay minerals in the pharmaceutical field. This study investigates the cellular uptake mechanisms of hectorite (Ht), a clay mineral with potential applications as a drug carrier. The study also explores the concept of covalently grafting the anticancer molecule methotrexate (MTX) onto Ht to form a nanomaterial. The results demonstrate the potential of Ht as a promising material for anticancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Si Xu, Shanshan Liang, Bing Wang, Jiali Wang, Meng Wang, Lingna Zheng, Hao Fang, Tingfeng Zhang, Yi Bi, Weiyue Feng
Summary: Pre-coating nanomaterials (NMs) with a protein corona is an effective strategy to reduce non-specific absorption of serum proteins while maintaining targeting specificity. This study presents a new approach using lipoic acid-terminated polyethylene glycol and transferrin bi-functionalized MoS2 nanosheets (Tf@MoS2-PEG NSs) to enhance cellular uptake. The results demonstrate that Tf coating enhances the cellular uptake of MoS2 NSs, with a broader range of uptake amounts observed in HepG2 cells compared to BSA-coated MoS2 NSs.
Article
Nanoscience & Nanotechnology
Anzhela Malysheva, Angela Ivask, Casey L. Doolette, Nicolas H. Voelcker, Enzo Lombi
Summary: The study demonstrates the presence of silver nanoparticles in nanoparticulate form after being taken up by human lymphocytes. Biotransformation of AgNPs is primarily dominated by sulfidation, serving as a detoxification pathway for cells. Toxicity of AgNPs is mainly driven by internalized silver, with differences in toxicity between nanoparticles of different coatings and sizes being minimized when expressed as intracellular mass of silver per cell.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
J. Pisonero, H. Traub, B. Cappella, C. Alvarez-Llamas, A. Mendez, S. Richter, J. Ruiz Encinar, J. M. Costa-Fernandez, N. Bordel
Summary: This study presents a novel approach to high spatially resolved quantitative bioimaging of Quantum Dots (QDs) uptake in single cells. By combining different techniques, the research provides a new perspective on quantifying elemental bioimages of CdSe/ZnS QDs uptake, shedding light on the distribution within the cells.
Article
Engineering, Environmental
Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Song
Summary: This study investigated the protein corona formed on PM2.5 particles in biological fluids and found differences in corona composition between plasma and after BALF exposure. The results showed an abundance of serum albumin, hemoglobin, and fibrinogen proteins in the corona, and highlighted the contributions of various types of interactions in the adsorption process. Additionally, the study demonstrated that the protein corona could affect cellular internalization of PM2.5 and subsequent oxidative stress responses.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Matthias Balk, Theresa Haus, Julia Band, Harald Unterweger, Eveline Schreiber, Ralf P. Friedrich, Christoph Alexiou, Antoniu-Oreste Gostian
Summary: This study investigated the magnetic properties, cellular uptake, and biocompatibility of two different types of SPIONs through various analytical methods. The results suggest the potential use of SPIONs as vehicles for MDT in head and neck cancer.
Article
Engineering, Biomedical
Tracie L. McGinnity, Viktoriya Sokolova, Oleg Prymak, Prakash D. Nallathamby, Matthias Epple, Ryan K. Roeder
Summary: The study demonstrated that hafnium oxide nanoparticles exhibit colloidal stability, cytocompatibility, and cellular uptake in vitro, making them a promising candidate for deliverable theranostics in nanomedicine.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Environmental Sciences
Anna Mittag, Christian Hoera, Alexander Kaempfe, Martin Westermann, Jochen Kuckelkorn, Thomas Schneider, Michael Glei
Summary: The study found that zinc oxide nanoparticles of different sizes have cellular uptake and toxic effects on human intestinal cells, especially showing cytotoxicity at high concentrations, which can accelerate cell apoptosis and death.
Article
Chemistry, Multidisciplinary
Jiali Zhai, Lei Bao, Anna K. K. Walduck, Brendan P. P. Dyett, Xudong Cai, Miaosi Li, Zeyad Nasa, Calum J. J. Drummond
Summary: This study reports a nanocomposite formulation consisting of nanosized C-dots encapsulated in lipid nanoparticles. The encapsulation enhances the cellular uptake efficiency and fluorescent properties of C-dots, thereby improving their bioimaging potential.
Article
Chemistry, Multidisciplinary
A. Jakhmola, S. Krishnan, V. Onesto, F. Gentile, M. Profeta, A. Manikas, E. Battista, R. Vecchione, P. A. Netti
Summary: This study developed a simple method for preparing gold nanoparticles with multimodal properties. The nanoparticles were synthesized using trisodium citrate as a reducing, stabilizing, and shape-modulating agent at room temperature. The resulting gold nanoparticles had diverse shapes, good monodispersity, high surface-enhanced Raman scattering activity, and a wide absorption range. The optical properties and growth characteristics of the nanoparticles were investigated experimentally and numerically. In vitro studies demonstrated the biocompatibility of the nanoparticles with cells.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhenqi Liu, Alison B. Lansley, Tu Ngoc Duong, John D. Smart, Ananth S. Pannala
Summary: This study investigated the potential of novel polymer-surfactant-based formulations to improve the solubility and permeability of curcumin. The results showed that formulation A, containing Soluplus (R) and vitamin E TPGs, significantly increased the permeation and cellular uptake of curcumin compared to other samples.
Article
Chemistry, Multidisciplinary
Ling Lin, Yexin Zheng, Chao Wang, Pei Li, Duoling Xu, Wei Zhao
Summary: As zero-dimension nanoparticles, graphene oxide quantum dots (GOQDs) have the potential to regulate cell proliferation and differentiation. This study investigated the effect and molecular mechanism of GOQDs on the odontoblastic differentiation of dental pulp cells (DPSCs). The results showed that low concentrations of GOQDs promoted the proliferation and odontoblastic differentiation of DPSCs, possibly through the activation of the AMPK signaling pathway and inhibition of the mTOR signaling pathway.
Article
Chemistry, Physical
Dexin Chen, Mengyuan Xu, Yanyue Liu, Rongying Wang, Zhaofeng Zhang, Kang Sun, Ke Tao
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Yan Liu, Yawen Xu, Xiangshuai Geng, Yingying Huo, Dexin Chen, Kang Sun, Guangdong Zhou, Biqiong Chen, Ke Tao
Article
Materials Science, Biomaterials
Dexin Chen, Daqian Wan, Rongying Wang, Yanyue Liu, Kang Sun, Xiaofeng Tao, Yang Qu, Kerong Dai, Songtao Ai, Ke Tao
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Dexin Chen, Daqian Wan, Rongying Wang, Yanyue Liu, Kang Sun, Xiaofeng Tao, Yang Qu, Kerong Dai, Songtao Ai, Ke Tao
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Chemistry, Multidisciplinary
Yan Liu, Yawen Xu, Zezhong Zhang, Yingying Huo, Dexin Chen, Wei Ma, Kang Sun, Gulen Yesilbag Tonga, Guangdong Zhou, Daniel S. Kohane, Ke Tao
Article
Chemistry, Multidisciplinary
Yan Liu, Yingying Huo, Lin Yao, Yawen Xu, Fanqiang Meng, Haifeng Li, Kang Sun, Guangdong Zhou, Daniel S. Kohane, Ke Tao
Article
Engineering, Biomedical
Jun Xue, Dida Duosiken, Shan Zhong, Jiao-Jiao Cao, Liang-Yun Hu, Kang Sun, Ke Tao, Si-Jian Pan
Summary: Radiosensitization by NaGdF4:Yb,Er nanoparticles was found to be effective even without modification of targeting ligands. The extent of mitochondrial targeting was closely related to sensitization efficiency, which was attributed to the activation of ROS-mediated TNF-JNK pathway and cell cycle arrest by RNA sequencing technique. This study suggests a strategy for enhancing radio-sensitization by utilizing subcellular targeting of nanoparticles.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Chu-Hsin Chen, Na Tang, Ke Xue, Hui-Zhong Zhang, Ya-Hong Chen, Peng Xu, Kang Sun, Ke Tao, Kai Liu
Summary: This study conducted tri-modal in vivo imaging of CSPCs using upconversion nanoparticles, enabling real-time quantitative monitoring of implanted cells. However, limitations in the detectable range of cell numbers were observed due to imaging shortcomings of UCNPs, which require further improvement.
Article
Chemistry, Multidisciplinary
Dida Duosiken, Ruihao Yang, Yingfan Dai, Zeinab Marfavi, Quanjie Lv, Hanyin Li, Kang Sun, Ke Tao
Summary: Thulium oxide nanoparticles show potential for generating ROS under NIR stimulation, demonstrating impressive tumor inhibition in photodynamic therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Yan Liu, Qelger Bao, Zheng Chen, Lin Yao, Zheng Ci, Xiangyu Wei, Yongjie Wu, Jin Zhu, Kang Sun, Guangdong Zhou, Shiting Li, Wei Ma, Ke Tao
Summary: Drug resistance is a major obstacle in cancer therapy, but nanoparticle-based photodynamic therapy shows promise in overcoming this challenge. By targeting multiple resistant pathways and inducing cell apoptosis via downstream genes, this therapy may offer a new approach to combat drug resistance in cancer.
Article
Materials Science, Biomaterials
Na Tang, Xueyi Wang, Jin Zhu, Kang Sun, Shiting Li, Ke Tao
Summary: Research on the use of multi-modal nanoparticles to label stem cells and detect their homing behavior via micro-CT imaging showed a higher homing efficiency of ADSCs in intravenously injected groups and the promoting effect of CXCL 12 on stem cell homing. However, the therapeutic efficacy of CXCL 12 was limited, while intravenous injection of ADSCs did not show significant results.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yanyue Liu, Yingfan Dai, Haifeng Li, Dida Duosiken, Na Tang, Kang Sun, Ke Tao
Summary: The longitudinal relaxivity of gadolinium oxide nanoparticles is found to be sensitively dependent on the numbers of H+ generated from the surface and in the environment, with nanoparticles of lower crystallinity exhibiting higher relaxivity. The isoelectric point is considered an indicator of longitudinal relaxivity, highlighting the impact of protons dissociated from the contrast agents.
NANOSCALE ADVANCES
(2021)
Article
Engineering, Biomedical
Yan Liu, Xiaodi Wu, Feifan Chen, Hao Li, Tao Wang, Ningning Liu, Kang Sun, Guangdong Zhou, Ke Tao
Summary: In this study, we found that nanoparticle-based photodynamic therapy disrupted the tumor-stroma crosstalk in pancreatic tumor models, leading to persistent inhibition of extracellular matrix secretion and enhanced therapeutic effect. By down-regulating TGF beta signaling pathways, this therapy decreased drug resistance, proliferation, and migration of cancer cells. Furthermore, it inactivated pancreatic stellate cells and hindered ECM secretion. The disruption of tumor-stroma crosstalk also improved tumor penetration in stroma-rich pancreatic tumor models, enhancing subsequent therapy outcomes.
Article
Chemistry, Multidisciplinary
Ran Xu, Fanqiang Meng, Yanyue Liu, Dida Duosiken, Kang Sun, Sijian Pan, Ke Tao
Summary: By controlling the size and lattice distortion of CaF2 nanocrystals, we accelerated their longitudinal relaxation, addressing the issue of unacceptable scanning time in MR imaging.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Deng Jie, Li Hai-Feng, Liu Yan, Tang Na, Sun Kang, Tao Ke
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Physical
Wenjing Tan, Chunmei Gao, Shifeng Ji, Yunqing Xing, Yi Guo, Baogui Liang
Summary: Membrane separation technology is widely used in wastewater treatment due to its cost-effectiveness and productivity. However, organic membrane fouling caused by humic acid is a major barrier to its further development. This study successfully addressed this issue through the production of composite materials and self-cleaning membranes, providing beneficial strategies and solutions for membrane contamination problems.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Qichang Peng, Qingdong Ruan, Bin Wang, Jinyuan Liu, Chao Huang, Xingwang Zhu, Dan Li, Liangliang Liu, Yinchuan Wang, Xiaolin Zhang, Jia Yan, Paul K. Chu, Hui Xu
Summary: The escalating issue of water pollution has led to significant attention in the field of photocatalysis. In this study, OV-Sb2WO6-X photocatalyst with oxygen vacancies was synthesized, which exhibited enhanced charge separation efficiency and improved photocatalytic activity. The introduction of oxygen vacancies was successfully controlled and characterized, and the modified photocatalyst showed superior degradation efficiency for dye wastewater treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Wangcheng Zhang, Cunchuan Zheng, Hu Xie, Weichao Du
Summary: By using a specific curing agent ETB, the problem of dispersion and stability for oily epoxy resin in cement slurry system has been successfully solved. The application of the emulsified curing agent ETB in oilfield cement slurry system shows good rheological performance, resistance to high temperature and high pressure water loss, and corrosion resistance.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
O. I. Krivonos, A. Babenko, O. B. Belskaya
Summary: This study synthesized biochar based on sapropel and investigated the effects of chemical modification on its textural characteristics, acid-base properties, and adsorption properties. The results showed that the chemical modification increased the fraction of micropores, specific surface area, and changed the surface properties of biochar. The experiment also revealed that biochar pretreated with alkali exhibited the maximum adsorption capacity for copper ions. A conceptual model identifying the mechanisms of copper adsorption on sapropel-based biosorbent was proposed.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
H. Lachhab, N. Benzbiria, A. Titi, S. Echihi, M. E. Belghiti, Y. Karzazi, A. Zarrouk, R. Touzani, C. Jama, F. Bentiss
Summary: The corrosion inhibitory potency of two new pyrimidine-pyrazole derivatives, PPA and PPC, was evaluated for mild steel in 1 M HCl. The results showed enhanced inhibition activities with increased concentration, reaching maximal values of 91.15% and 92.39% for PPA and PPC, respectively. However, the mitigation potency decreased with increasing temperature. SEM and XPS analysis revealed that PPA and PPC adsorbed on the mild steel surface, forming a shielding layer that prevented the dissolution of the steel in the acidic solution.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Shanmugapriya Sivalingam, D. Jeya Sundara Sharmila, Goutham Golla, Lakshmanan Arunachalam, Tarunendu Singh, G. Karthikeyan, A. Shanthi, Kannan Malaichamy
Summary: This study aims to develop a nano-biofungicide comprising of volatile essential oil molecules to enhance its efficacy in the field of agriculture through easily scalable green synthesis technique. The nano biofungicide was prepared through one pot hot melt ultrasonication technique with easy water dispersibility and long term stability. The physico-chemical analysis revealed that, nano bio-fungicides were amorphous sphere-shaped nanoparticles with low melting point. The encapsulation efficiency of major components of essential oil was determined, and it was found that they followed Higuchi model of release kinetics. The essential oil loaded nanostructured lipid carrier showed significantly higher mycelial growth inhibition compared to pure essential oil, indicating enhanced bio-efficacy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Yinlong Li, Yingqing Zhan, Yiwen Chen, Hongshan Jia, Ximin Chen, Fei Zhu, Xulin Yang
Summary: In this study, ZnO quantum dots decorated MXene nanosheets were used as a functional filler for waterborne epoxy coating. The improved dispersion and synergy of ZnO QDs and MXene nanosheets enhanced the anticorrosion performance of the coating.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Fucheng Guan, Jing Tao, Qiang Yao, Zheng Li, Yihang Zhang, Shi Feng, Jianbin Sun, Qiang Yang, Xuecui Song, Jing Guo, Yuanfa Liu
Summary: This paper presents a method for preparing adsorbent materials based on biomass that can efficiently adsorb methylene blue. The experimental results show that the material has a hierarchical structure, high adsorption capacity, and reusability.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Pengfei Hu, Zuli Mo, Weiliang Wang, Chengzhe Li, Zhaojia Guo, Guanqing Lin, Zhimin Guo
Summary: This study developed a novel in-situ particle vision and measurement (PVM) system to investigate heterocoagulation between coarse and fine particles in mineral processing. The experimental results showed that the degree of heterocoagulation decreased with increasing pH and stirring speed. Furthermore, under certain hydrodynamic conditions, coal particles were more distributed at the rear of the glass bead.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Tanveer ul Haq Zia, Anwar ul Haq Ali Shah, Behisht Ara, Kashif Gul
Summary: A label-free immunosensor for detection of hepatitis C core antigen was fabricated using a ternary nanocomposite based on polypyrrole, silver doped zinc oxide, and exfoliated graphene. The immunosensor demonstrated low detection limit, high selectivity, and stability.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Xiaoyan Feng, Jiachen Li, Lijun Liang, Linli Zhu, Sa Liu, Li Ren
Summary: In this study, polystyrene divinylbenzene microspheres were surface-modified by poly(carboxybetaine methacrylate) to develop an efficient hemoperfusion adsorbent for the removal of protein-bound toxins. The modified microspheres showed increased adsorption capacity and better biocompatibility, making them promising for clinical hemoperfusion therapy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Xiaoye Bi, Dong Xue, Yunpeng Wang, Chencheng Lv, Zexiong Li, Tao Zhao
Summary: This research aimed to develop a durable and formaldehyde-free flame retardant treatment for cotton fabrics. The results demonstrated successful grafting of phosphorous acid (PA) onto cotton fabrics, leading to enhanced flame resistance while maintaining the desired fabric characteristics.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Ruolin Wang, Wenjuan Sun, Haisheng Han, Dongping Tao
Summary: This study finds that Al-starch colloidal depressants can effectively inhibit the flotation of ultrafine calcite and chlorite, and increase the grade of valuable minerals. The chemisorption of Al-starch on mineral surface changes the functional group peaks and generates new O-Al functional groups.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Wondimu K. Wakejo, Ali Maged, Beteley T. Meshesha, Joon W. Kang, Abayneh G. Demesa, Sandip Chakrabarti, Thallada Bhaskar, Ashok Kumar Gupta, Amit Bhatnagar
Summary: Simultaneously removing different pharmaceutical pollutants from wastewater is an important environmental issue, and the use of a system that can remove multiple contaminants at once is necessary. Functionalized biochar (FBC) has been found to be effective in simultaneously removing acetaminophen and ciprofloxacin and other pharmaceutical pollutants.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Physical
Yu Wang, Fengwen Yan, Jie Wu, Zhijun Huang, Liuting Song, Shunda Yuan
Summary: In this study, Cu single atoms are anchored on the external surface of g-C3N4 nanofibers to maximize atom utilization. This catalyst exhibits excellent Fenton-like catalytic activity and good stability due to the full utilization of Cu active sites.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)