期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 370, 期 1-3, 页码 28-34出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2010.08.039
关键词
Electrospray; Microcapsule; Polyelectrolyte; High encapsulation efficiency
资金
- MEXT, Japan
- Kao Foundation for Arts and Sciences
- Ministry of Environment, Japan [K2119]
The preparation of polyelectrolyte microcapsules by electrospray was investigated. When a polyanionic or polycationic aqueous solution was electrosprayed into an aqueous solution containing a polyelectrolyte with the opposite charge, a spherical interface consisting of a polyelectrolyte complex was formed by electrostatic interaction to produce a microcapsule. Alginate/chitosan microcapsules (similar to 100 mu m) were successfully produced with a narrow diameter distribution (coefficient of variation 4.4%). The diameters of microcapsules were controlled in the range of 80-230 mu m by varying the operating conditions, such as feed rate, working voltage, the distance from needle-to-collector, needle diameter and polyelectrolyte concentrations. We also succeeded in the encapsulation of protein, dextran and a polymeric microsphere within the polyelectrolyte microcapsules with high encapsulation efficiencies (more than 99%). The study of yeast encapsulation reveals that the electrospray technique can encapsulate a physiologically active substrate in the polyelectrolyte microcapsule and maintain its activity. (C) 2010 Elsevier B.V. All rights reserved.
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