期刊
COLLOID AND POLYMER SCIENCE
卷 292, 期 10, 页码 2475-2484出版社
SPRINGER
DOI: 10.1007/s00396-014-3260-6
关键词
Supercritical processing; Nanoparticles; Polymers; Controlled release
资金
- Spanish Government [MAT2010-18155, MAT2012-35324, MAT2012-35161]
- Generalitat de Catalunya [2009SGR203, 2009SGR666]
- COST Action [MP1202]
- Spanish Education Ministry
The overall objective of the present work was to modulate the release behavior of drug-impregnated silica particles from almost instantaneous release to a more sustained delivery, prolonged during several hours. Triflusal was chosen as a model drug of the low biodisponibility type. The process is based in the coating with EudragitA (R) RL 100 polymer of aerogel-like silica particles. Materials were processed in compressed CO2 by using the batch and semicontinuous antisolvent coating methods. Triflusal release from Eudragit-coated aerogel particles was compared with the dissolution profiles recorded for pristine triflusal and for triflusal impregnated into polymer or non-coated aerogel particles. The release profiles were determined by high-performance liquid chromatography. Eudragit-coated materials presented an intermediate drug-release rate between this obtained for the infused polymer and that of the impregnated aerogel particles. Diffusion-governed mechanisms were found for the studied aerogel-like systems after fitting the release data to both Korsmeyer-Peppas and Baker-Lonsdale equations. The major advantage of the compressed CO2 antisolvent approach was the ability to physically coat very fine particles (< 100 nm). Moreover, the stability of the studied drug in water increased after coating.
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