期刊
COGNITIVE NEURODYNAMICS
卷 4, 期 4, 页码 359-366出版社
SPRINGER
DOI: 10.1007/s11571-010-9129-6
关键词
Working memory; Bistability; Computational model; Calcium signaling
资金
- National Natural Science Foundation of China (NSFC) [10872068, 10672057]
- Fundamental Research Funds for the Central Universities
Camperi and Wang (Comput Neurosci 5:383-405, 1998) presented a network model for working memory that combines intrinsic cellular bistability with the recurrent network architecture of the neocortex. While Fall and Rinzel (Comput Neurosci 20:97-107, 2006) replaced this intrinsic bistability with a biological mechanism-Ca2+ release subsystem. In this study, we aim to further expand the above work. We integrate the traditional firing-rate network with Ca2+ subsystem-induced bistability, amend the synaptic weights and suggest that Ca2+ concentration only increase the efficacy of synaptic input but has nothing to do with the external input for the transient cue. We found that our network model maintained the persistent activity in response to a brief transient stimulus like that of the previous two models and the working memory performance was resistant to noise and distraction stimulus if Ca2+ subsystem was tuned to be bistable.
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