Article
Pediatrics
Amirmohammad Tajik, Shekoufeh Nikfar, Sepideh Elyasi, Omid Rajabi, Mehdi Varmaghani
Summary: LDX therapy for ADHD is associated with higher costs but appears to be a cost-effective choice compared to MPH, based on the Incremental Cost-Effectiveness Ratio (ICER) and probabilities calculated in the study. Incorporating LDX into Iran's healthcare system may result in a financial burden initially, but could provide benefits over time in managing ADHD.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Psychology, Clinical
Lenard A. Adler, Terry L. Leon, Taylor M. Sardoff, Beth Krone, Stephen Faraone, Michael J. Silverstein, Jeffrey H. Newcorn
Summary: The study investigated the efficacy of LDX versus placebo in treating adults with ADHD and SCT through a randomized crossover trial. It found that LDX significantly improved SCT, ADHD, executive function deficits, and functional impairment ratings compared to placebo.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Psychology, Developmental
Ann C. Childress, Eric Lloyd, Leslie Jacobsen, Lhanoo Gunawardhana, Steven A. Johnson, Robert L. Findling
Summary: This study evaluated the acute efficacy, safety, and tolerability of lisdexamfetamine dimesylate (LDX) vs placebo (PBO) in preschool-aged children with attention-deficit/hyperactivity disorder (ADHD). LDX was found to be more effective than PBO in reducing symptoms and was generally well tolerated.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Pediatrics
Ann C. Childress, Eric Lloyd, Steven A. Johnson, Lhanoo Gunawardhana, Valerie Arnold
Summary: This study evaluated the long-term safety and tolerability of lisdexamfetamine dimesylate (LDX) in preschool-aged children (4-5 years old) with attention-deficit/hyperactivity disorder (ADHD). The results showed that the optimized dosage of LDX (5-30 mg) was well tolerated and led to reductions in ADHD symptoms compared to baseline.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sneha M. Vaddadi, Nicholas J. Czelatka, Belsy D. Gutierrez, Bhumika C. Maddineni, Kenneth L. McCall, Brian J. Piper
Summary: In recent years, the use of prescription stimulants in the United States has been increasing, particularly for amphetamine and lisdexamfetamine. The study found that the usage of stimulants in the Western region was lower compared to other regions, and areas with a higher percentage of Hispanic populations also had lower stimulant usage.
Article
Medicine, General & Internal
Johannes Lieslehto, Jari Tiihonen, Markku Laehteenvuo, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Heidi Taipale
Summary: This study investigated the impact of pharmacotherapy on suicide risk in patients with borderline personality disorder (BPD). The results indicated that ADHD medication may reduce the risk of suicide, while mood stabilizers and antidepressants may increase the risk. The findings suggest that benzodiazepines should be used with caution due to their association with increased suicide risk in patients with BPD.
Article
Neurosciences
Jose Ramon Gutierrez-Casares, Cristina Segu-Verges, Juncal Sabate Chueca, Tamara Pozo-Rubio, Mireia Coma, Carmen Montoto, Javier Quintero
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric condition that can continue into adulthood and is often accompanied by other psychiatric comorbidities. Lisdexamfetamine (LDX) is a stimulant prodrug approved for treating ADHD and binge eating disorder (BED). Through a computational model, we evaluated the efficacy of a virtual model of LDX (vLDX) as ADHD treatment in improving five common ADHD psychiatric comorbidities in adults and children, and explored the molecular mechanisms underlying the predicted efficacy of LDX.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
Luisa Shiguemi Sugaya, Giovanni Abrahao Salum, Wagner de Sousa Gurgel, Erika Mendonca de Morais, Giovana Del Prette, Caroline Drehmer Pilatti, Bianca Batista Dalmaso, Ellen Leibenluft, Luis Augusto Rohde, Guilherme Vanoni Polanczyk
Summary: This study found that methylphenidate and behavioral parent training have significant effects in reducing symptoms and improving functionality for preschool children aged 3-5 with ADHD after 8 weeks of treatment.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Education, Special
Noelia Ruiz-Herrera, Nicola Cellini, Alexander Prehn-Kristensen, Alejandro Guillen-Riquelme, Gualberto Buela-Casal
Summary: This study aimed to investigate the role of sleep spindle activity in differentiating ADHD presentations, and the results showed that spindle characteristics in children with ADHD evolve with age, but are not related to IQ.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2021)
Article
Psychiatry
Jose Ramon Gutierrez-Casares, Javier Quintero, Guillem Jorba, Valentin Junet, Vicente Martinez, Tamara Pozo-Rubio, Baldomero Oliva, Xavier Daura, Jose Manuel Mas, Carmen Montoto
Summary: This study established models based on systems biology, completed a virtual clinical trial through three phases, and compared two treatments for attention-deficit/hyperactivity disorder. The results showed that conducting clinical trials using computer technology can greatly reduce costs and time, providing possibilities for the development of personalized medicine.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Developmental
W. L. Zijlema, Y. de Kluizenaar, I. van Kamp, C. A. Hartman
Summary: The study did not find evidence for a harmful association between road traffic noise and ADHD symptoms, but observed associations between noise and lower risks for ADHD only in cases with confirmed ADHD diagnosis, which may be due to residual confounding or selection bias. Future studies should focus on residential and school noise exposure, and study associations with ADHD symptoms and diagnosis over time.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Pediatrics
Meritxell Rojo-Marticella, Victoria Arija, Paula Morales-Hidalgo, Patricia Esteban-Figuerola, Nuria Voltas-Moreso, Josefa Canals-Sans
Summary: This study aimed to describe the anthropometric status of school children with ADHD, comparing their age and clinical presentation with control children. The results showed that preschoolers with hyperactive-impulsive ADHD were taller, while elementary school children with combined ADHD were shorter and smaller. Medication may affect the height of children with inattentive presentation. Anthropometric and dietary monitoring should be recommended to parents of children with ADHD.
PEDIATRIC RESEARCH
(2023)
Article
Psychiatry
Max M. Owens, Nicholas Allgaier, Sage Hahn, DeKang Yuan, Matthew Albaugh, Shana Adise, Bader Chaarani, Joseph Ortigara, Anthony Juliano, Alexandra Potter, Hugh Garavan
Summary: The study found that the brain correlates of ADHD symptomatology are modest in effect size and are best captured by brain morphometry and activation during a working memory task.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Pediatrics
Yuan-Chang Hsu, Chih-Tsai Chen, Hao-Jan Yang, Pesus Chou
Summary: This study aims to evaluate the relationship between family, personal, and parental factors and behavioral disturbances in boys with ADHD. Through medical records and questionnaires, it was found that these factors were associated with severe internalizing behavior, severe externalizing behavior, and the number of behavioral disturbances.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)