Article
Immunology
Ping Chen, Xue-Yan Liu, Mou-Hui Lin, Yu-Xi Li, De-Zhi Kang, Zu-Cheng Ye, Qing-Song Lin
Summary: NeuroD1 administration attenuated reactive astrocytes-mediated neuroinflammation and boosted neurogenesis in both transfected cells and endogenous cells in different phases after SAH, contributing to neurofunctional recovery.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Hyeuk Cha, Jun Ho Choi, Hanwool Jeon, Jae Hyun Kim, Moinay Kim, Su Jung Kim, Wonhyoung Park, Joon Seo Lim, Eunyeup Lee, Jae Sung Ahn, Jeong Hoon Kim, Seok Ho Hong, Ji Eun Park, Jin Hwa Jung, Hyun Ju Yoo, Seungjoo Lee
Summary: Cognitive impairment refers to declines in cognitive abilities leading to the inability to accomplish essential activities. Astrocytes and the ANLS system are crucial for cognitive function. AQP-4, expressed in astrocytes, is associated with brain disorders, but its relationship with learning and memory is unclear. Our study found that AQP-4 deficiency in mice led to behavioral and emotional changes, impaired cognitive functions, and metabolic alterations in the brain. The deficiency of AQP-4 disrupted the metabolic function of astrocytes and the ANLS system.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Critical Care Medicine
Daniel C. Lu, Zsolt Zador, Jinghua Yao, Farbod Fazlollahi, Geoffrey T. Manley
Summary: This study demonstrates a protective role of AQP4 in post-traumatic seizure susceptibility by promoting astrogliosis, formation of a glial scar, and preventing microgliosis.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Psychiatry
Tao Yan, Yuefeng Qiu, Xinfeng Yu, Linglin Yang
Summary: Mounting evidence suggests a close relationship between sleep disturbance and mood disorders, with recent findings on the glymphatic system pointing towards a potential bridge linking the two.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Markou, Philip Kitchen, Ahmed Aldabbagh, Mariaelena Repici, Mootaz M. Salman, Roslyn M. Bill, Zita Balklava
Summary: The AQP4 water channel plays a crucial role in brain swelling following insults like traumatic injury or stroke, with its trafficking mechanisms involving early and recycling endosomes as well as cytoskeleton dynamics. AQP4 constantly cycles between the cell surface and intracellular vesicles in mammalian cells, with internalisation being dynamin-dependent. Targeting Rab5, Rab11, and cytoskeleton dynamics could provide potential avenues for edema treatment.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Nadia Skauli, Ekaterina Savchenko, Ole Petter Ottersen, Laurent Roybon, Mahmood Amiry-Moghaddam
Summary: This study suggests that the canonical BMP-signaling pathway may play a role in regulating the expression of AQP4 and the subcellular compartmentation of the associated DAP complex, thereby impacting the development of neurological conditions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shreyas B. Rao, Nadia Skauli, Nenad Jovanovic, Shirin Katoozi, Antonio Frigeri, Stanley C. Froehner, Marvin E. Adams, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Summary: The study reveals the interdependence between astrocytic AQP4 and gap junctions, with limited impact on AQP4 isoform expression from deletion of beta 1-syntrophin, but with increased astrocytic gap junctions from double knockout of alpha 1- and beta 1-syntrophin. It highlights the importance of syntrophins in organizing specialized functional domains of brain astrocytes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Cell Biology
Guoyong Ren, Pan Xue, Bin Wu, Fei Yang, Xuemei Wu
Summary: The study found a significant correlation between depressive symptoms and olfactory deficits. The intranasal treatment with GLP-1 analog lixisenatide showed potential as an antidepressant by improving olfactory and emotional functions.
Article
Multidisciplinary Sciences
Matthijs C. Dorst, Maria Diaz-Moreno, David O. Dias, Eduardo L. Guimaraes, Daniel Holl, Jannis Kalkitsas, Gilad Silberberg, Christian Goritz
Summary: Research has shown that inhibition of Notch signaling in astrocytes can induce adult striatal neurogenesis in the intact mouse brain. These astrocyte-derived neurons possess distinct electrophysiological properties, constituting the only glutamatergic striatal population, and have the potential to compensate for reduced neuronal activity in the striatal circuitry caused by aging or lesion-induced neuronal loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Vasil Kecheliev, Leo Boss, Upasana Maheshwari, Uwe Konietzko, Annika Keller, Daniel Razansky, Roger M. Nitsch, Jan Klohs, Ruiqing Ni
Summary: The aim of this study is to investigate the neurovascular alterations, distribution and dislocation of aquaporin 4 (AQP4) associated with tau and amyloid-beta (Aβ) pathologies in Alzheimer's disease. The PR5 mouse model showed regional atrophy, preserved cerebral blood flow, reduced cerebral vessel density, and AQP4 dislocation and peri-tau enrichment in the hippocampus. On the other hand, the arcAβ mouse model showed cerebral microbleeds, reduced cerebral vessel density, cortical AQP4 dislocation, and cortical/hippocampal peri-plaque increases.
Article
Psychiatry
Shuai Yang, Xiao-Yi Kong, Ting Hu, Yi-Jun Ge, Xue-Yan Li, Jun-Tao Chen, Shuo He, Ping Zhang, Gui-Hai Chen
Summary: This study found that CID patients have decreased serum levels of AQP4, CX30, and CX43, indicating astrocyte dysfunction, which may be related to poor sleep quality and cognitive dysfunction.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Yong-Zhen Guo, Yan-Mei Ma, Xiao-Peng Zhang, Ling-Di Dong, Li Jing, Jian-Zhong Zhang
Summary: Brain edema is a major cause of death in patients who suffer an ischemic stroke. Diabetes aggravates brain edema after cerebral ischemia-reperfusion, with different effects observed in various brain regions. Hyperglycemia can significantly impact the distribution of aquaporin 4 and increase the number of swelling cells in the striatal penumbra compared to the cortical penumbra.
NEUROSCIENCE LETTERS
(2021)
Article
Clinical Neurology
Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O'Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff
Summary: This study found that the loss of perivascular localization of AQP4 is associated with the development of A beta plaques and cognitive decline in subjects with Alzheimer's disease (AD). Rodent studies also showed that loss of AQP4 localization leads to abnormal distribution of CSF tracer and increased levels of amyloid beta.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Immunology
Shuwen Deng, Xiqian Chen, Qiang Lei, Wei Lu
Summary: The decrease of serum AQP2 levels after intracerebral hemorrhage (ICH) is negatively correlated with poor prognosis, indicating it may be a marker of early-stage inflammation. AQP2 overexpression promotes astrocyte activation and pro-inflammatory secretion, affects astrocyte-microglia crosstalk, and indirectly induces microglial polarization, which may augment inflammation after ICH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Jian Li, Zhiqiang Jia, Qiangqiang Zhang, Junyu Dai, Jundong Kong, Zhongkai Fan, Gang Li
Summary: Blocking p-ERK1/2 effectively inhibits astrocyte proliferation and proinflammatory cytokine release, preserves surviving ventral horn neurons, and improves locomotor function in rats after SCI.
BRAIN RESEARCH BULLETIN
(2021)
Article
Immunology
Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu, Gang Hu
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Behavioral Sciences
Yunluo Lv, Wangshu Dai, Ai Ge, Yi Fan, Gang Hu, Yinming Zeng
BRAIN AND BEHAVIOR
(2018)
Article
Cell Biology
Shi Xu, Beibei Yang, Tingting Tao, Ji Zhang, Yun Liu, Jun Hu, Yi Fan, Guangdong Zhang
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Jun Hua, Nuo Yin, Shi Xu, Qiang Chen, Tingting Tao, Ji Zhang, Jianhua Ding, Yi Fan, Gang Hu
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Article
Cell Biology
Zhe Wei, Maoxiang Zhang, Chunman Li, Wei Huang, Yi Fan, Jianhui Guo, Mostafa Khater, Mitsunori Fukuda, Zheng Dong, Gang Hu, Guangyu Wu
Article
Neurosciences
Ye Hua, Beibei Yang, Qiang Chen, Ji Zhang, Jun Hu, Yi Fan
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Cell Biology
Jifeng Zhao, Yun Li, Yan Li, Shi Xu, Tingting Tao, Ye Hua, Ji Zhang, Yi Fan
Summary: Research has shown that the activation of alpha 7-nAChRs can protect against cell damage induced by alpha Syn, suggesting a neuroprotective effect in Parkinson's disease. Studies on normal and alpha Syn transduced cells have revealed the role of alpha 7-nAChRs in promoting the clearance of alpha Syn and reducing its aggregation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yunnan Lu, Mingming Zhou, Yun Li, Yan Li, Ye Hua, Yi Fan
Summary: The study found that minocycline can promote microglial phenotype shift, reduce brain infarct volume, protect neurons from injury, and improve neurological functional recovery after AIS.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Yuan Liu, Shi Xu, Haijun Zhang, Kaoliang Qian, Jiachen Huang, Xianger Gu, Yan Li, Yi Fan, Jun Hu
Summary: OA patients showed decreased levels of alpha 7-nAChRs and an imbalance between autophagy and apoptosis in knee joint cartilage tissues.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Hai-Yue Tu, Bao-Shi Yuan, Xiao-Ou Hou, Xiao-Jun Zhang, Chong-Shuang Pei, Ya-Ting Ma, Ya-Ping Yang, Yi Fan, Zheng-Hong Qin, Chun-Feng Liu, Li-Fang Hu
Summary: The extracellular transfer of alpha-Synuclein (alpha-Syn) contributes to Parkinson's disease pathogenesis by activating microglia and neuroinflammation. This study found that extracellular alpha-Syn inhibits microglia autophagy through Toll-like receptor 4 (Tlr4)-mediated p38 and Akt-mTOR signaling pathways, leading to neuroinflammation and PD development.
Article
Cell Biology
Li Sun, Wen-Wen Jiang, Ye Wang, Yong-Sheng Yuan, Zhe Rong, Jing Wu, Yi Fan, Ming Lu, Ke-Zhong Zhang
Summary: The study demonstrates that in PD mice models, p-alpha-syn can accumulate in SCs of sciatic nerves, resulting in damage to SCs and axons. It is confirmed that the TLR2/NF-κB pathway plays a role in PD peripheral neuropathy, and treatment with CU-CPT22 can improve motor and sensory functions associated with the condition.
CELL DEATH DISCOVERY
(2021)
Article
Neurosciences
Ye Hua, Wenjing Han, Linfeng Zhou, Jing Gao, Jifeng Zhao, Nanshan Song, Bin Hu, Qingyu Yao, Yumin Liu, Deen Xu, Yunnan Lu, Yi Fan
Summary: This study demonstrates the imbalance of netrin-1 (NTN-1) and deleted in colorectal carcinoma (DCC) signaling in the progression of Parkinson's disease (PD). Through the establishment of experimental PD models, it was found that the imbalance of NTN-1 and DCC is a common feature of nigral dopaminergic neuron injury. Further experiments revealed that MPP+ inhibits NTN-1 expression and increases DCC expression. Additionally, a significant decrease in plasma NTN-1 levels and a positive correlation with UPDRS scores were observed in PD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Linfeng Zhou, Yun Li, Min Wang, Wenjing Han, Qiang Chen, Ji Zhang, Bo Sun, Yi Fan
Summary: Epidemiological studies have shown that women have a lower susceptibility to Parkinson's disease (PD) compared to men. This study investigated the expression and aggregation of a-Syn protein in the brains of women after menopause. The findings suggest that menopause may disrupt a-Syn proteostasis and worsen its accumulation in the basal ganglia circuit.
Meeting Abstract
Pharmacology & Pharmacy
Weijie Cheng, Zaian Bi, Huan Gao, Yi Fan, Xingying Liu, Chenyang Zhang, Min Ye
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Meeting Abstract
Pharmacology & Pharmacy
Weijie Cheng, Zaian Bi, Huan Gao, Yi Fan, Xingyin Liu, Chenyang Zhang, MinYe
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)