Article
Biochemistry & Molecular Biology
Nicole Zarate, Taylor A. Intihar, Dahyun Yu, Jacob Sawyer, Wei Tsai, Maha Syed, Luke Carlson, Rocio Gomez-Pastor
Summary: PSD-95 levels are reduced in aging and neurodegenerative diseases like Huntington's disease, along with depletion of Heat Shock transcription Factor 1 (HSF1). HSF1 directly regulates PSD-95 expression, playing a crucial role in synaptic gene regulation with implications in synapse maintenance under both basal and pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Vishaal Rajani, Ameet S. Sengar, Michael W. Salter
Summary: SFKs are crucial non-receptor tyrosine kinases in multiple signalling pathways, playing a key role in regulating NMDAR function and neuronal transduction pathways. Src and Fyn members of SFKs are essential for inducing plasticity at hippocampal synapses, while aberrant regulation of NMDARs by SFKs is implicated in diseases like schizophrenia and pain hypersensitivity. The targeting of SFK protein-protein interactions could be a potential therapeutic strategy for restoring glutamatergic dysregulation in CNS disease pathophysiology.
Article
Clinical Neurology
Pia Kivisakk, Becky C. Carlyle, Thadryan Sweeney, James P. Quinn, Christopher E. Ramirez, Bianca A. Trombetta, Muriel Mendes, Mary Brock, Carrie Rubel, Julie Czerkowicz, Danielle Graham, Steven E. Arnold
Summary: This study measured the levels of synaptic proteins in cerebrospinal fluid (CSF) and found that these proteins could potentially serve as biomarkers for cognitive decline in Alzheimer's disease (AD). The levels of the synaptic proteins were higher in AD patients compared to those with other neurodegenerative diseases and healthy controls, but were not specific to AD and could also be present in cases with inflammatory or vascular disorders.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ligia Fao, Patricia Coelho, Luis Duarte, Rita Vilaca, Michael R. Hayden, Sandra I. Mota, Ana Cristina Rego
Summary: This study demonstrates that c-Src/Fyn proteins play an important role in controlling mitochondrial function and redox regulation in Huntington's disease (HD). Restoring c-Src/Fyn levels in HD improves mitochondrial morphology and function, reducing the levels of oxidant species and cell death. These findings suggest that c-Src/Fyn could be a potential therapeutic target for HD.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Plant Sciences
Zhen-Tao Mo, Jie Zheng, Yu-ling Liao
Summary: The study demonstrated that Icariin may reduce the expression of IL-1 beta, IL-6 and TNF-alpha by inhibiting the IRE1/XBP1s pathway, suggesting a potential therapeutic strategy for brain injury after stroke.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Neurosciences
Bianca Guglietti, Srisankavi Sivasankar, Sanam Mustafa, Frances Corrigan, Lyndsey E. Collins-Praino
Summary: Fyn, a non-receptor tyrosine kinase, is implicated in various functions in the central nervous system and its dysfunction is associated with neurodegenerative diseases. Neurodegenerative diseases are a major cause of death and disability worldwide, with no disease-modifying therapies currently available.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chenjie Ge, Xuefeng Wang, Yunhong Wang, Lilei Lei, Guohua Song, Mincai Qian, Shiliang Wang
Summary: The present study investigated the role of PKC epsilon in brain ischemia-induced dendritic spine dysfunction. The study found that PKC epsilon kinase activity increased after oxygen-glucose deprivation (OGD) treatment, leading to dendritic spine dysfunction. Inhibiting PKC epsilon activity rescued dendritic spine function and revealed that PKC epsilon activates downstream molecule RhoA to cause dendritic spine changes. This study provides insights into a novel mechanism underlying brain ischemia-induced cognitive impairment and AD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Neurosciences
Gui-Mei Wu, Cai-Ping Du, Yan Xu
Summary: This study demonstrates that A beta oligomers induce tyrosine phosphorylation of PSD-95 through the activation of GluN2A and GluN2B-containing NMDA receptors, mediated by SrcPTKs.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Immunology
Ruili Wang, Lei Li, Baogong Wang
Summary: Poncirin protects cortical neurons from oxygen-glucose deprivation/reoxygenation injury by inhibiting the NOX4/ROS/NLRP3 axis. It alleviates neuronal damage caused by mitochondrial dysfunction, oxidative stress, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leszek Szablewski
Summary: Alzheimer's disease is the most common cause of dementia in elderly people, with aging being a main risk factor. Impairment of brain energy and glucose hypometabolism are hallmarks of the disease. There are several hypotheses on the role of glucose hypometabolism in AD, but further investigations are needed on this subject.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xiaoyan Ren, Jiangang Yu, Lili Guo, Hong Ma
Summary: The study showed that DPP3 plays a neuroprotective role in neurons injured by OGD/R by suppressing apoptosis, oxidative stress, and inflammation through modulation of the Keap1/Nrf2 signaling pathway. The findings suggest DPP3 as a potential target for providing neuroprotective effects during cerebral ischemia/reperfusion injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhanyang Yu, Wenlu Li, Jing Lan, Kazuhide Hayakawa, Xunming Ji, Eng H. Lo, Xiaoying Wang
Summary: The study suggests that ephrin-B2-EphB2 signaling may serve as a promising therapeutic target for protecting both neuronal soma and dendrites against ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Jie Shao, Xiang Yin, Yue Lang, Manqiu Ding, Baizhuo Zhang, Qingqing Sun, Xiaoyu Jiang, Jia Song, Li Cui
Summary: Cellular prion protein (PrPC) skews microglia towards an anti-inflammatory state by enhancing and prolonging autophagy activation, thereby attenuating ischemic stroke-induced damage.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
Xiuwen Kang, Lei Jiang, Xufeng Chen, Xi Wang, Shuangshuang Gu, Jun Wang, Yuanhui Zhu, Xuexue Xie, Hang Xiao, Jinsong Zhang
Summary: Exosomes derived from bone marrow mesenchymal stromal cells have been shown to have significant neuroprotective effects against NLRP3 inflammasome-mediated pyroptosis in cerebral ischemic diseases. Hypoxic exosomes demonstrate more pronounced protective effects compared to normoxic exosomes, indicating their potential for clinical use in treating cerebral ischemia and hypoxia injuries.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Benita Wiatrak, Janusz Piasny, Amadeusz Kuzniarski, Kazimierz Gasiorowski
Summary: As the elderly population increases globally, there is a growing concern about neurodegenerative diseases like Alzheimer's disease. The understanding of the pathomechanism and effective treatment for this disease still remains a challenge.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Xiao-Hui Yin, Jing-Zhi Yan, Guo Yang, Li Chen, Xiao-Feng Xu, Xi-Ping Hong, Shi-Liang Wu, Xiao-Yu Hou, GuangYi Zhang
Article
Geriatrics & Gerontology
Bin Hu, Chi Geng, Xiao-Yu Hou
NEUROBIOLOGY OF AGING
(2017)
Article
Neurosciences
Fang Zhou, Yan Xu, Xiao-Yu Hou
JOURNAL OF NEUROSCIENCE RESEARCH
(2014)
Article
Neurosciences
Chao Zhao, Cai-Ping Du, Yan Peng, Zhen Xu, Chang-Cheng Sun, Yong Liu, Xiao-Yu Hou
MOLECULAR NEUROBIOLOGY
(2015)
Article
Neurosciences
X. -H. Yin, J-Z Yan, X-Y Hou, S. -L. Wu, G. -Y. Zhang
Article
Neurosciences
Yan Xu, Da-Hong Cao, Gui-Mei Wu, Xiao-Yu Hou
NEUROSCIENCE RESEARCH
(2014)
Article
Multidisciplinary Sciences
Qiu-Ju Zhu, Fan-Shu Kong, Hao Xu, Yi Wang, Cai-Ping Du, Chang-Cheng Sun, Yong Liu, Ting Li, Xiao-Yu Hou
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Cell Biology
Gui-Ying Yao, Qian Zhu, Jing Xia, Feng-Jiao Chen, Ming Huang, Jing Liu, Ting-Ting Zhou, Jian-Feng Wei, Gui-Yun Cui, Kui-Yang Zheng, Xiao-Yu Hou
CELL DEATH & DISEASE
(2018)
Article
Neurosciences
Hui Li, Xiao-Bing Luo, Yan Xu, Xiao-Yu Hou
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Cai-Ping Du, Mei Wang, Chi Geng, Bin Hu, Li Meng, Yan Xu, Bao Cheng, Nan Wang, Qiu-Ju Zhu, Xiao-Yu Hou
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Oncology
Yan Zhu, Jin-Min Sun, Zi-Chen Sun, Feng-Jiao Chen, Yong-Ping Wu, Xiao-Yu Hou
Summary: MLK3 has been found to be highly expressed in high-grade human glioma specimens, especially in GBM, and correlated with poor prognosis in IDH-wt gliomas. Additionally, MLK3 promotes GBM cell migration and invasion by remodeling the actin cytoskeleton through MLK3-EPS8 signaling.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou
Summary: This study revealed that neuronal activity induced SUMOylation of Akt1 by SUMO1, mediated by PIAS3, which enhanced Akt1's enzymatic activity and facilitated its phosphorylation. This process is involved in ERK1/2-BDNF/Arc and mTOR-4E-BP1 signaling pathways, contributing to long-lasting excitatory synaptic responses and synaptic plasticity.
Article
Geriatrics & Gerontology
Bin Hu, Chi Geng, Feng Guo, Ying Liu, Yu-Chen Zong, Xiao-Yu Hou
Summary: Olfactory damage occurs early in Alzheimer's disease, potentially related to impaired inhibitory transmission. Experimental evidence suggests that deficits in presynaptic GABAergic transmission may contribute to olfactory dysfunction and the progression of AD.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Yan Xu, Meng-Lin Wang, Hui Tao, Chi Geng, Feng Guo, Bin Hu, Ran Wang, Xiao-Yu Hou
Summary: Consolidated memories can impact later learning and cognitive processes, with cellular and molecular factors like ErbB4 in parvalbumin (PV)-positive interneurons playing a key role in proactive interference. The study showed that genetic ablation of ErbB4 in PV interneurons improved performance in reversal-learning phase, highlighting the importance of ErbB4 in this process. Mechanistically, olfactory learning promoted synaptic plasticity and interaction of ErbB4 with key proteins in the prefrontal cortex, affecting excitatory synapse formation and neuronal activity. These findings provide novel insights into the role of ErbB4 signaling in cognitive processes and its impact on local inhibitory circuit plasticity and proactive interference.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Nan Wang, Xiao-Yu Hou
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)